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Protein

Sodium-coupled neutral amino acid transporter 9

Gene

Slc38a9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acids. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids, suggesting that it acts as an amino acid sensor instead. The high concentration of arginine in lysosomes suggests that it acts as an arginine sensor.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-coupled neutral amino acid transporter 9Curated
Alternative name(s):
Solute carrier family 38 member 9Imported
Gene namesi
Name:Slc38a9Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1311881. Slc38a9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 118CytoplasmicBy similarityAdd BLAST118
Transmembranei119 – 139Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini140 – 143LumenalCurated4
Transmembranei144 – 164Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini165 – 197CytoplasmicCuratedAdd BLAST33
Transmembranei198 – 218Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini219 – 288LumenalCuratedAdd BLAST70
Transmembranei289 – 309Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini310 – 311CytoplasmicCurated2
Transmembranei312 – 332Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini333 – 356LumenalCuratedAdd BLAST24
Transmembranei357 – 377Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini378 – 390CytoplasmicCuratedAdd BLAST13
Transmembranei391 – 411Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini412 – 438LumenalCuratedAdd BLAST27
Transmembranei439 – 459Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini460 – 475CytoplasmicCuratedAdd BLAST16
Transmembranei476 – 496Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini497 – 505LumenalCurated9
Transmembranei506 – 526Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini527 – 538CytoplasmicCuratedAdd BLAST12
Transmembranei539 – 559Helical; Name=11Sequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003288421 – 559Sodium-coupled neutral amino acid transporter 9Add BLAST559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi238N-linked (GlcNAc...)PROSITE-ProRule annotation1
Glycosylationi247N-linked (GlcNAc...)PROSITE-ProRule annotation1
Glycosylationi264N-linked (GlcNAc...)PROSITE-ProRule annotation1

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ3B8Q3.
PRIDEiQ3B8Q3.

Expressioni

Gene expression databases

BgeeiENSRNOG00000009851.
ExpressionAtlasiQ3B8Q3. baseline and differential.
GenevisibleiQ3B8Q3. RN.

Interactioni

Subunit structurei

Associated component of the Ragulator complex (composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5). Associated component of the Rag GTPases heterodimers (composed of RRAGA, RRAGB, RRAGC and RRAGD).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013218.

Family & Domainsi

Domaini

The cytosolic N-terminus part of the protein mediates interaction with the Ragulator complex and the Rag GTPases heterodimers.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1305. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00390000005646.
HOGENOMiHOG000294102.
HOVERGENiHBG106242.
InParanoidiQ3B8Q3.
KOiK14995.
OMAiDCIEQNF.
OrthoDBiEOG091G04X6.
PhylomeDBiQ3B8Q3.
TreeFamiTF312989.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3B8Q3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANVDSDSRH LISEVEHEVN PGPMNIQFDS SDLRSKRPFY IEPTNIVNVN
60 70 80 90 100
DVIQKVSDHA AAMNKRIHYY SRLTTPADKA LIAPDHVVPA PEECYVYSPL
110 120 130 140 150
GSAYKLKSYT EGYRKNTSLV TIFMIWNTMM GTSILSIPWG IKQAGFTTGM
160 170 180 190 200
CVIVLMGLLT LYCCYRVVKS RSMIVTSDTT TWEYPDVCKH YFGSFGQWSS
210 220 230 240 250
LLFSLVSLIG AMIVYWVLMS NFLFNTGKFI FNFIHHINDT DTVLSTNNSS
260 270 280 290 300
PVICPSAGSG HPDNSSMIFY NSDTEVRLFE RWWDKSKTVP FYLIGLLLPL
310 320 330 340 350
LNFKSPSFFS KFNILGTVSV LYLIFIVTLK AIRLGFHLEF HWFAPTEFFV
360 370 380 390 400
PEIRAQFPQL TGVLTLAFFI HNCIITLLKN NKNQENNVRD LCIAYMLVTL
410 420 430 440 450
TYLYIGVLVF ASFPSPPLPK DCIEQNFLDN FPSSDTLSFI ARICLLFQMM
460 470 480 490 500
TVYPLLGYLA RVQLLGHIFG DIYPSIFHVL ILNLIIVGAG VTMACFYPNI
510 520 530 540 550
GGIIRYSGAA CGLAFVFIYP SLIYILSQHQ EERLTWPKLV FHIIIIILGL

ANLIAQFFM
Length:559
Mass (Da):63,418
Last modified:November 22, 2005 - v1
Checksum:iB5311209F1530CC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06012861 Genomic DNA. No translation available.
BC092662 mRNA. Translation: AAH92662.1.
BC105869 mRNA. Translation: AAI05870.1.
RefSeqiNP_001030328.1. NM_001035251.1.
XP_006231991.1. XM_006231929.3.
XP_006231992.1. XM_006231930.3.
XP_006231993.1. XM_006231931.3.
XP_006231994.1. XM_006231932.2.
XP_006231995.1. XM_006231933.2.
UniGeneiRn.136906.
Rn.60851.

Genome annotation databases

EnsembliENSRNOT00000013218; ENSRNOP00000013218; ENSRNOG00000009851.
GeneIDi310091.
KEGGirno:310091.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06012861 Genomic DNA. No translation available.
BC092662 mRNA. Translation: AAH92662.1.
BC105869 mRNA. Translation: AAI05870.1.
RefSeqiNP_001030328.1. NM_001035251.1.
XP_006231991.1. XM_006231929.3.
XP_006231992.1. XM_006231930.3.
XP_006231993.1. XM_006231931.3.
XP_006231994.1. XM_006231932.2.
XP_006231995.1. XM_006231933.2.
UniGeneiRn.136906.
Rn.60851.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013218.

Proteomic databases

PaxDbiQ3B8Q3.
PRIDEiQ3B8Q3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013218; ENSRNOP00000013218; ENSRNOG00000009851.
GeneIDi310091.
KEGGirno:310091.

Organism-specific databases

CTDi153129.
RGDi1311881. Slc38a9.

Phylogenomic databases

eggNOGiKOG1305. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00390000005646.
HOGENOMiHOG000294102.
HOVERGENiHBG106242.
InParanoidiQ3B8Q3.
KOiK14995.
OMAiDCIEQNF.
OrthoDBiEOG091G04X6.
PhylomeDBiQ3B8Q3.
TreeFamiTF312989.

Miscellaneous databases

PROiQ3B8Q3.

Gene expression databases

BgeeiENSRNOG00000009851.
ExpressionAtlasiQ3B8Q3. baseline and differential.
GenevisibleiQ3B8Q3. RN.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS38A9_RAT
AccessioniPrimary (citable) accession number: Q3B8Q3
Secondary accession number(s): Q561Z8, R9PXU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: November 22, 2005
Last modified: November 2, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.