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Q3B8P0

- PARL_RAT

UniProt

Q3B8P0 - PARL_RAT

Protein

Presenilins-associated rhomboid-like protein, mitochondrial

Gene

Parl

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals By similarity.By similarity

    Catalytic activityi

    Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei275 – 2751NucleophileBy similarity
    Active sitei333 – 3331By similarity

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Presenilins-associated rhomboid-like protein, mitochondrial (EC:3.4.21.105)
    Alternative name(s):
    Mitochondrial intramembrane-cleaving protease PARL
    Cleaved into the following chain:
    P-beta
    Short name:
    Pbeta
    Gene namesi
    Name:ParlBy similarity
    Synonyms:PsarlImported
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1306191. Parl.

    Subcellular locationi

    Peptide P-beta : Nucleus By similarity
    Note: Translocated into the nucleus by an unknown mechanism.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 5050MitochondrionBy similarityAdd
    BLAST
    Chaini51 – 377327Presenilins-associated rhomboid-like protein, mitochondrialPRO_0000257987Add
    BLAST
    Peptidei51 – 7525P-betaBy similarityPRO_0000257988Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei63 – 631PhosphoserineBy similarity
    Modified residuei68 – 681PhosphoserineBy similarity

    Post-translational modificationi

    P-beta is proteolytically processed (beta-cleavage) in a PARL-dependent manner.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ3B8P0.
    PRIDEiQ3B8P0.

    PTM databases

    PhosphoSiteiQ3B8P0.

    Expressioni

    Gene expression databases

    GenevestigatoriQ3B8P0.

    Interactioni

    Subunit structurei

    Interacts with PSEN1 and PSEN2. Binds OPA1 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ3B8P0.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini51 – 9545Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini117 – 16549Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini187 – 21428Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini236 – 2427Mitochondrial intermembraneSequence Analysis
    Topological domaini264 – 2685Mitochondrial matrixSequence Analysis
    Topological domaini290 – 2934Mitochondrial intermembraneSequence Analysis
    Topological domaini315 – 33117Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini353 – 37725Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei96 – 11621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei166 – 18621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei215 – 23521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei243 – 26321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei269 – 28921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei294 – 31421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei332 – 35221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S54 family.Sequence Analysis

    Keywords - Domaini

    Transit peptide, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0705.
    HOGENOMiHOG000230670.
    HOVERGENiHBG082107.
    InParanoidiQ3B8P0.
    KOiK09650.
    PhylomeDBiQ3B8P0.

    Family and domain databases

    Gene3Di1.20.1540.10. 1 hit.
    InterProiIPR002610. Peptidase_S54_rhomboid.
    IPR022764. Peptidase_S54_rhomboid_dom.
    [Graphical view]
    PANTHERiPTHR22936. PTHR22936. 1 hit.
    PfamiPF01694. Rhomboid. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: Q3B8P0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MALYSWVQRG WRCGQTWAPL LGGGYRELSA TQARQLLGRR FNLLLQQKCG    50
    FRKAPRKVEP RRSDTGSSGE AYKRSALIPP LEETVFYPSP YPVRTLLKPF 100
    FFTVGFTGCA FGSAAIWQYE SLKSRVQSYF DGIKADWLDS IRPQKEGNLR 150
    KEINKWWNSL SDGQRTVTGI IAANALVFCL WRVPSLHRTM IRYFTSNPAS 200
    KVLCSPMLLS TFSHFSLFHM AANMYVLWSF STSIVNILGQ EQFVAVYLSA 250
    GVISNFVSYV CKVATGRYGP SLGASGAIMT VLAAVCTKIP EGRLAIIFLP 300
    VFTFTAGNAL KAIIAMDTAG MILGWKFFDH AAHLGGALFG IWYITYGHEL 350
    IWKNREPLVK IWHEIRTNGP KKGGGSK 377
    Length:377
    Mass (Da):42,126
    Last modified:November 22, 2005 - v1
    Checksum:i4E27E9216BC0548C
    GO
    Isoform 21 Publication (identifier: Q3B8P0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         93-105: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:364
    Mass (Da):40,619
    Checksum:i282E7DA066C64A04
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei93 – 10513Missing in isoform 2. 1 PublicationVSP_052185Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC088226 mRNA. Translation: AAH88226.1.
    BC105907 mRNA. Translation: AAI05908.1.
    RefSeqiNP_001030326.1. NM_001035249.1. [Q3B8P0-1]
    UniGeneiRn.7053.

    Genome annotation databases

    GeneIDi287979.
    KEGGirno:287979.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC088226 mRNA. Translation: AAH88226.1 .
    BC105907 mRNA. Translation: AAI05908.1 .
    RefSeqi NP_001030326.1. NM_001035249.1. [Q3B8P0-1 ]
    UniGenei Rn.7053.

    3D structure databases

    ProteinModelPortali Q3B8P0.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q3B8P0.

    Proteomic databases

    PaxDbi Q3B8P0.
    PRIDEi Q3B8P0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 287979.
    KEGGi rno:287979.

    Organism-specific databases

    CTDi 55486.
    RGDi 1306191. Parl.

    Phylogenomic databases

    eggNOGi COG0705.
    HOGENOMi HOG000230670.
    HOVERGENi HBG082107.
    InParanoidi Q3B8P0.
    KOi K09650.
    PhylomeDBi Q3B8P0.

    Miscellaneous databases

    NextBioi 627335.

    Gene expression databases

    Genevestigatori Q3B8P0.

    Family and domain databases

    Gene3Di 1.20.1540.10. 1 hit.
    InterProi IPR002610. Peptidase_S54_rhomboid.
    IPR022764. Peptidase_S54_rhomboid_dom.
    [Graphical view ]
    PANTHERi PTHR22936. PTHR22936. 1 hit.
    Pfami PF01694. Rhomboid. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: LiverImported and ThymusImported.

    Entry informationi

    Entry nameiPARL_RAT
    AccessioniPrimary (citable) accession number: Q3B8P0
    Secondary accession number(s): Q5I0L2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3