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Protein

TSC22 domain family protein 4

Gene

Tsc22d4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
TSC22 domain family protein 4
Alternative name(s):
TSC22-related-inducible leucine zipper protein 2
Thg-1pit
Gene namesi
Name:Tsc22d4
Synonyms:Tilz2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1584380. Tsc22d4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 387387TSC22 domain family protein 4PRO_0000417669Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei57 – 571PhosphothreonineBy similarity
Modified residuei62 – 621PhosphoserineBy similarity
Modified residuei165 – 1651PhosphoserineCombined sources
Modified residuei183 – 1831PhosphothreonineBy similarity
Modified residuei187 – 1871PhosphoserineBy similarity
Modified residuei189 – 1891PhosphoserineBy similarity
Modified residuei223 – 2231PhosphothreonineCombined sources
Modified residuei254 – 2541PhosphoserineBy similarity
Modified residuei258 – 2581PhosphoserineBy similarity
Modified residuei271 – 2711PhosphoserineCombined sources
Modified residuei362 – 3621PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3B8N7.

PTM databases

iPTMnetiQ3B8N7.
PhosphoSiteiQ3B8N7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000024616.
ExpressionAtlasiQ3B8N7. baseline.
GenevisibleiQ3B8N7. RN.

Interactioni

Subunit structurei

Forms a homodimer or heterodimer. Can form a heterodimer with TSC22D1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000056350.

Structurei

3D structure databases

ProteinModelPortaliQ3B8N7.
SMRiQ3B8N7. Positions 318-371.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni336 – 35722Leucine-zipperAdd
BLAST

Sequence similaritiesi

Belongs to the TSC-22/Dip/Bun family.Curated

Phylogenomic databases

eggNOGiKOG4797. Eukaryota.
ENOG411251N. LUCA.
GeneTreeiENSGT00530000063062.
HOGENOMiHOG000253006.
HOVERGENiHBG069048.
InParanoidiQ3B8N7.
OMAiCVDIYER.
OrthoDBiEOG091G06PM.
PhylomeDBiQ3B8N7.

Family and domain databases

InterProiIPR000580. TSC-22_Dip_Bun.
[Graphical view]
PANTHERiPTHR12348. PTHR12348. 1 hit.
PfamiPF01166. TSC22. 1 hit.
[Graphical view]
ProDomiPD007152. TSC-22_Dip_Bun. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01289. TSC22. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3B8N7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGGKKKSSF QITSVTTDYE GPGSPGASDP PAPPAPAGPP PRLPNGEPNP
60 70 80 90 100
DPGGRGTPRN GSPPPGAPAS RFRVVKLPQG LGEPYRRGRW TCVDVYERDL
110 120 130 140 150
EPPSFGRLLE GIRGASGGTG GRSLDSRLEL ASLGISTPIP QPGLSQGPTS
160 170 180 190 200
WLRPPPTSPG PQARSFTGGL GQLAGPGKAK VETPPLSASP PQQRPPGPGT
210 220 230 240 250
GDSAQTLPSL RVEVESGGLA AGTPPLSRRR DGAVRLRMEL VAPEETGKVP
260 270 280 290 300
PIDSRPNSPA LYFDASLVHK SPDPFGAAAA QSLSLARSML AISGHLDSDD
310 320 330 340 350
DSGSGSLVGI DNKIEQAMDL VKSHLMFAVR EEVEVLKEQI RDLAERNAAL
360 370 380
EQENGLLRAL ASPEQLAQLP SSGLPRLGPS APNGPSI
Length:387
Mass (Da):40,041
Last modified:November 22, 2005 - v1
Checksum:i20B00F4ACFB8F739
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473973 Genomic DNA. Translation: EDM13242.1.
BC105911 mRNA. Translation: AAI05912.1.
RefSeqiNP_001037749.1. NM_001044284.3.
XP_006249139.1. XM_006249077.2.
UniGeneiRn.21359.
Rn.224681.
Rn.224768.

Genome annotation databases

EnsembliENSRNOT00000039280; ENSRNOP00000033658; ENSRNOG00000050805.
ENSRNOT00000059592; ENSRNOP00000056350; ENSRNOG00000024616.
GeneIDi102550456.
684980.
KEGGirno:102550456.
rno:684980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473973 Genomic DNA. Translation: EDM13242.1.
BC105911 mRNA. Translation: AAI05912.1.
RefSeqiNP_001037749.1. NM_001044284.3.
XP_006249139.1. XM_006249077.2.
UniGeneiRn.21359.
Rn.224681.
Rn.224768.

3D structure databases

ProteinModelPortaliQ3B8N7.
SMRiQ3B8N7. Positions 318-371.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000056350.

PTM databases

iPTMnetiQ3B8N7.
PhosphoSiteiQ3B8N7.

Proteomic databases

PaxDbiQ3B8N7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000039280; ENSRNOP00000033658; ENSRNOG00000050805.
ENSRNOT00000059592; ENSRNOP00000056350; ENSRNOG00000024616.
GeneIDi102550456.
684980.
KEGGirno:102550456.
rno:684980.

Organism-specific databases

CTDi81628.
RGDi1584380. Tsc22d4.

Phylogenomic databases

eggNOGiKOG4797. Eukaryota.
ENOG411251N. LUCA.
GeneTreeiENSGT00530000063062.
HOGENOMiHOG000253006.
HOVERGENiHBG069048.
InParanoidiQ3B8N7.
OMAiCVDIYER.
OrthoDBiEOG091G06PM.
PhylomeDBiQ3B8N7.

Miscellaneous databases

PROiQ3B8N7.

Gene expression databases

BgeeiENSRNOG00000024616.
ExpressionAtlasiQ3B8N7. baseline.
GenevisibleiQ3B8N7. RN.

Family and domain databases

InterProiIPR000580. TSC-22_Dip_Bun.
[Graphical view]
PANTHERiPTHR12348. PTHR12348. 1 hit.
PfamiPF01166. TSC22. 1 hit.
[Graphical view]
ProDomiPD007152. TSC-22_Dip_Bun. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01289. TSC22. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiT22D4_RAT
AccessioniPrimary (citable) accession number: Q3B8N7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2012
Last sequence update: November 22, 2005
Last modified: September 7, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.