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Protein

Galectin-9B

Gene

LGALS9B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds galactosides.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-9B
Short name:
Gal-9B
Alternative name(s):
Galectin-9-like protein A
Gene namesi
Name:LGALS9B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:24842. LGALS9B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162393903.

Polymorphism and mutation databases

BioMutaiLGALS9B.
DMDMi205371780.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356Galectin-9BPRO_0000321949Add
BLAST

Proteomic databases

PaxDbiQ3B8N2.
PRIDEiQ3B8N2.

PTM databases

iPTMnetiQ3B8N2.

Expressioni

Gene expression databases

BgeeiQ3B8N2.
CleanExiHS_LGALS9B.
ExpressionAtlasiQ3B8N2. baseline and differential.

Organism-specific databases

HPAiHPA046876.
HPA047218.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DAB1O755533EBI-10240775,EBI-7875264
PRTFDC1Q9NRG13EBI-10240775,EBI-739759
WWP2O003083EBI-10240775,EBI-743923

Protein-protein interaction databases

BioGridi129785. 5 interactions.
IntActiQ3B8N2. 4 interactions.
STRINGi9606.ENSP00000315564.

Structurei

3D structure databases

ProteinModelPortaliQ3B8N2.
SMRiQ3B8N2. Positions 3-356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 148132Galectin 1PROSITE-ProRule annotationAdd
BLAST
Domaini228 – 356129Galectin 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni82 – 887Beta-galactoside binding 1By similarity
Regioni288 – 2947Beta-galactoside binding 2By similarity

Sequence similaritiesi

Contains 2 galectin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3587. Eukaryota.
ENOG4111EA0. LUCA.
GeneTreeiENSGT00760000119105.
HOGENOMiHOG000290194.
HOVERGENiHBG002412.
InParanoidiQ3B8N2.
KOiK10093.
OMAiFQVSINH.
OrthoDBiEOG73Z2TM.
PhylomeDBiQ3B8N2.
TreeFamiTF315551.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS51304. GALECTIN. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3B8N2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFSGSQAPY LSPAVPFSGT IQGGLQDGFQ ITVNGAVLSS SGTRFAVDFQ
60 70 80 90 100
TGFSGNDIAF HFNPRFEDGG YVVCNTRQKG RWGPEERKMH MPFQKGMPFD
110 120 130 140 150
LCFLVQSSDF KVMVNGSLFV QYFHRVPFHR VDTISVNGSV QLSYISFQNP
160 170 180 190 200
RTVPVQPAFS TVPFSQPVCF PPRPRGRRQK PPSVRPANPA PITQTVIHTV
210 220 230 240 250
QSASGQMFSQ TPAIPPMMYP HPAYPMPFIT TIPGGLYPSK SIILSGTVLP
260 270 280 290 300
SAQRFHINLC SGSHIAFHMN PRFDENAVVR NTQINNSWGS EERSLPRKMP
310 320 330 340 350
FVRGQSFSVW ILCEAHCLKV AVDGQHVFEY YHRLRNLPTI NKLEVGGDIQ

LTHVQT
Length:356
Mass (Da):39,660
Last modified:September 2, 2008 - v3
Checksum:iBD0FB91708EA5A4A
GO
Isoform 2 (identifier: Q3B8N2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-210: Missing.

Note: No experimental confirmation available.
Show »
Length:355
Mass (Da):39,532
Checksum:i48ED76D4B4020568
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61S → C in BAF82952 (PubMed:14702039).Curated
Sequence conflicti152 – 1521T → A in AAI05944 (PubMed:15489334).Curated
Sequence conflicti185 – 1851R → Q in BAF82952 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei210 – 2101Missing in isoform 2. 1 PublicationVSP_035176

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290263 mRNA. Translation: BAF82952.1.
AC015818 Genomic DNA. No translation available.
AC087499 Genomic DNA. No translation available.
BC105943 mRNA. Translation: AAI05944.1.
BM769345 mRNA. No translation available.
BM769737 mRNA. No translation available.
CCDSiCCDS42283.1. [Q3B8N2-2]
RefSeqiNP_001036150.1. NM_001042685.1. [Q3B8N2-2]
XP_006721568.2. XM_006721505.2. [Q3B8N2-1]
UniGeneiHs.462402.
Hs.610820.

Genome annotation databases

EnsembliENST00000324290; ENSP00000315564; ENSG00000170298. [Q3B8N2-2]
ENST00000423676; ENSP00000388841; ENSG00000170298. [Q3B8N2-1]
GeneIDi284194.
KEGGihsa:284194.
UCSCiuc002gwz.1. human. [Q3B8N2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290263 mRNA. Translation: BAF82952.1.
AC015818 Genomic DNA. No translation available.
AC087499 Genomic DNA. No translation available.
BC105943 mRNA. Translation: AAI05944.1.
BM769345 mRNA. No translation available.
BM769737 mRNA. No translation available.
CCDSiCCDS42283.1. [Q3B8N2-2]
RefSeqiNP_001036150.1. NM_001042685.1. [Q3B8N2-2]
XP_006721568.2. XM_006721505.2. [Q3B8N2-1]
UniGeneiHs.462402.
Hs.610820.

3D structure databases

ProteinModelPortaliQ3B8N2.
SMRiQ3B8N2. Positions 3-356.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129785. 5 interactions.
IntActiQ3B8N2. 4 interactions.
STRINGi9606.ENSP00000315564.

PTM databases

iPTMnetiQ3B8N2.

Polymorphism and mutation databases

BioMutaiLGALS9B.
DMDMi205371780.

Proteomic databases

PaxDbiQ3B8N2.
PRIDEiQ3B8N2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324290; ENSP00000315564; ENSG00000170298. [Q3B8N2-2]
ENST00000423676; ENSP00000388841; ENSG00000170298. [Q3B8N2-1]
GeneIDi284194.
KEGGihsa:284194.
UCSCiuc002gwz.1. human. [Q3B8N2-1]

Organism-specific databases

CTDi284194.
GeneCardsiLGALS9B.
HGNCiHGNC:24842. LGALS9B.
HPAiHPA046876.
HPA047218.
neXtProtiNX_Q3B8N2.
PharmGKBiPA162393903.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3587. Eukaryota.
ENOG4111EA0. LUCA.
GeneTreeiENSGT00760000119105.
HOGENOMiHOG000290194.
HOVERGENiHBG002412.
InParanoidiQ3B8N2.
KOiK10093.
OMAiFQVSINH.
OrthoDBiEOG73Z2TM.
PhylomeDBiQ3B8N2.
TreeFamiTF315551.

Miscellaneous databases

ChiTaRSiLGALS9B. human.
GenomeRNAii284194.
PROiQ3B8N2.

Gene expression databases

BgeeiQ3B8N2.
CleanExiHS_LGALS9B.
ExpressionAtlasiQ3B8N2. baseline and differential.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS51304. GALECTIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "21C frontier Korean EST project 2001."
    Kim N.S., Hahn Y., Oh J.H., Lee J.Y., Ahn H.Y., Chu M.Y., Kim M.R., Oh K.J., Cheong J.E., Sohn H.Y., Kim J.M., Park H.S., Kim S., Kim Y.S.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 169-356 (ISOFORM 2).
    Tissue: Stomach.

Entry informationi

Entry nameiLEG9B_HUMAN
AccessioniPrimary (citable) accession number: Q3B8N2
Secondary accession number(s): A6NLF8, A8K2J8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 2, 2008
Last modified: June 8, 2016
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The LGALS9-like proteins are encoded by a duplicated regions on chromosome 17; there are at least 3 genes coding for galectin-9-like proteins.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.