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Q3B8J8 (SDHB_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

EC=1.3.5.1
Alternative name(s):
Iron-sulfur subunit of complex II
Short name=Ip
Gene names
Name:sdhb
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length282 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity.

Catalytic activity

Succinate + a quinone = fumarate + a quinol.

Cofactor

Binds 1 2Fe-2S cluster By similarity.

Binds 1 3Fe-4S cluster By similarity.

Binds 1 4Fe-4S cluster By similarity.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.

Subunit structure

Component of complex II composed of four subunits: the flavoprotein (FP) sdha, iron-sulfur protein (IP) sdhb, and a cytochrome b composed of sdhc and sdhd By similarity.

Subcellular location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side By similarity.

Sequence similarities

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 1 4Fe-4S ferredoxin-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2626Mitochondrion By similarity
Chain27 – 282256Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
PRO_0000343802

Regions

Domain42 – 135942Fe-2S ferredoxin-type
Domain178 – 208314Fe-4S ferredoxin-type

Sites

Metal binding951Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1001Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1031Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1151Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1881Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1911Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1941Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1981Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2451Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2511Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2551Iron-sulfur 2 (4Fe-4S) By similarity
Binding site2031Ubiquinone; shared with dhsd By similarity

Experimental info

Sequence conflict1641K → E in AAH43859. Ref.1
Sequence conflict2791A → V in AAH43859. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q3B8J8 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: FCEE9AA00E84E689

FASTA28231,777
        10         20         30         40         50         60 
MAAVVFSLRR SGPVLRLSGA LQVSRGAQTA AAPASQAAAR IKKFAIYRWD PDKPGDKPRM 

        70         80         90        100        110        120 
QTYEVDLNTC GPMVLDALIK IKNEVDPTLT FRRSCREGIC GSCAMNINGG NTLACTVRID 

       130        140        150        160        170        180 
TNLSKVSKIY PLPHMYVVKD LVPDLSNFYA QYKSIEPYLK KKDKSQQGKE QYLQSIEDRD 

       190        200        210        220        230        240 
KLDGLYECIL CACCSTSCPS YWWNADKYLG PAVLMQAYRW MIDSRDDFTE ERLSKLQDPF 

       250        260        270        280 
SLYRCHTIMN CTRTCPKGLN PGKAIAEIKK MMAMYKERAV SA 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo and Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC043859 mRNA. Translation: AAH43859.1.
BC106300 mRNA. Translation: AAI06301.1.
RefSeqNP_001080247.1. NM_001086778.1.
UniGeneXl.12560.

3D structure databases

ProteinModelPortalQ3B8J8.
SMRQ3B8J8. Positions 40-277.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ3B8J8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID379939.
KEGGxla:379939.

Organism-specific databases

CTD6390.
XenbaseXB-GENE-970197. sdhb.

Phylogenomic databases

HOVERGENHBG005483.
KOK00235.

Enzyme and pathway databases

UniPathwayUPA00223; UER01006.

Family and domain databases

Gene3D3.10.20.30. 1 hit.
InterProIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsTIGR00384. dhsB. 1 hit.
PROSITEPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSDHB_XENLA
AccessionPrimary (citable) accession number: Q3B8J8
Secondary accession number(s): Q7ZYB6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: November 22, 2005
Last modified: April 16, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways