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Q3B8J8

- SDHB_XENLA

UniProt

Q3B8J8 - SDHB_XENLA

Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Gene

sdhb

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (22 Nov 2005)
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    Functioni

    Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

    Catalytic activityi

    Succinate + a quinone = fumarate + a quinol.

    Cofactori

    Binds 1 2Fe-2S cluster.By similarity
    Binds 1 3Fe-4S cluster.By similarity
    Binds 1 4Fe-4S cluster.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi95 – 951Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi100 – 1001Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi103 – 1031Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi115 – 1151Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi188 – 1881Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi191 – 1911Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi194 – 1941Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi198 – 1981Iron-sulfur 3 (3Fe-4S)By similarity
    Binding sitei203 – 2031Ubiquinone; shared with dhsdBy similarity
    Metal bindingi245 – 2451Iron-sulfur 3 (3Fe-4S)By similarity
    Metal bindingi251 – 2511Iron-sulfur 3 (3Fe-4S)By similarity
    Metal bindingi255 – 2551Iron-sulfur 2 (4Fe-4S)By similarity

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB
    2. 3 iron, 4 sulfur cluster binding Source: UniProtKB
    3. 4 iron, 4 sulfur cluster binding Source: UniProtKB
    4. electron carrier activity Source: InterPro
    5. metal ion binding Source: UniProtKB-KW
    6. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
    7. ubiquinone binding Source: UniProtKB

    GO - Biological processi

    1. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport, Tricarboxylic acid cycle

    Keywords - Ligandi

    2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00223; UER01006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC:1.3.5.1)
    Alternative name(s):
    Iron-sulfur subunit of complex II
    Short name:
    Ip
    Gene namesi
    Name:sdhb
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-970197. sdhb.

    Subcellular locationi

    Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB
    2. mitochondrial respiratory chain complex II Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2626MitochondrionBy similarityAdd
    BLAST
    Chaini27 – 282256Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialPRO_0000343802Add
    BLAST

    Proteomic databases

    PRIDEiQ3B8J8.

    Interactioni

    Subunit structurei

    Component of complex II composed of four subunits: the flavoprotein (FP) sdha, iron-sulfur protein (IP) sdhb, and a cytochrome b composed of sdhc and sdhd.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ3B8J8.
    SMRiQ3B8J8. Positions 40-277.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini42 – 135942Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini178 – 208314Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
    Contains 1 4Fe-4S ferredoxin-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOVERGENiHBG005483.
    KOiK00235.

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    InterProiIPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR012675. Beta-grasp_dom.
    IPR009051. Helical_ferredxn.
    IPR004489. Succ_DH/fum_Rdtase_Fe-S.
    IPR025192. Succ_DH/fum_Rdtase_N.
    [Graphical view]
    PfamiPF13085. Fer2_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF46548. SSF46548. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsiTIGR00384. dhsB. 1 hit.
    PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
    PS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q3B8J8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAVVFSLRR SGPVLRLSGA LQVSRGAQTA AAPASQAAAR IKKFAIYRWD    50
    PDKPGDKPRM QTYEVDLNTC GPMVLDALIK IKNEVDPTLT FRRSCREGIC 100
    GSCAMNINGG NTLACTVRID TNLSKVSKIY PLPHMYVVKD LVPDLSNFYA 150
    QYKSIEPYLK KKDKSQQGKE QYLQSIEDRD KLDGLYECIL CACCSTSCPS 200
    YWWNADKYLG PAVLMQAYRW MIDSRDDFTE ERLSKLQDPF SLYRCHTIMN 250
    CTRTCPKGLN PGKAIAEIKK MMAMYKERAV SA 282
    Length:282
    Mass (Da):31,777
    Last modified:November 22, 2005 - v1
    Checksum:iFCEE9AA00E84E689
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti164 – 1641K → E in AAH43859. 1 PublicationCurated
    Sequence conflicti279 – 2791A → V in AAH43859. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC043859 mRNA. Translation: AAH43859.1.
    BC106300 mRNA. Translation: AAI06301.1.
    RefSeqiNP_001080247.1. NM_001086778.1.
    UniGeneiXl.12560.

    Genome annotation databases

    GeneIDi379939.
    KEGGixla:379939.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC043859 mRNA. Translation: AAH43859.1 .
    BC106300 mRNA. Translation: AAI06301.1 .
    RefSeqi NP_001080247.1. NM_001086778.1.
    UniGenei Xl.12560.

    3D structure databases

    ProteinModelPortali Q3B8J8.
    SMRi Q3B8J8. Positions 40-277.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q3B8J8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 379939.
    KEGGi xla:379939.

    Organism-specific databases

    CTDi 6390.
    Xenbasei XB-GENE-970197. sdhb.

    Phylogenomic databases

    HOVERGENi HBG005483.
    KOi K00235.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER01006 .

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    InterProi IPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR012675. Beta-grasp_dom.
    IPR009051. Helical_ferredxn.
    IPR004489. Succ_DH/fum_Rdtase_Fe-S.
    IPR025192. Succ_DH/fum_Rdtase_N.
    [Graphical view ]
    Pfami PF13085. Fer2_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46548. SSF46548. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsi TIGR00384. dhsB. 1 hit.
    PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
    PS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo and Testis.

    Entry informationi

    Entry nameiSDHB_XENLA
    AccessioniPrimary (citable) accession number: Q3B8J8
    Secondary accession number(s): Q7ZYB6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3