Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Metalloendopeptidase

Gene

ASTL

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

  1. metalloendopeptidase activity Source: InterPro
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, MetalloproteaseUniRule annotation, Protease

Keywords - Ligandi

Metal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
MetalloendopeptidaseUniRule annotation (EC:3.4.24.-UniRule annotation)
Gene namesi
Name:ASTLImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222UniRule annotationAdd
BLAST
Chaini23 – 430408MetalloendopeptidaseUniRule annotationPRO_5001352590Add
BLAST

Proteomic databases

PRIDEiQ3B826.

Structurei

3D structure databases

ProteinModelPortaliQ3B826.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M12A family.UniRule annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

HOVERGENiHBG080299.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
[Graphical view]
PfamiPF01400. Astacin. 1 hit.
[Graphical view]
PRINTSiPR00480. ASTACIN.
SMARTiSM00235. ZnMc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q3B826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EGVGGLWPWV LGLLSLPGVI LGAPLASSCA GACGTSFPDG LTPEGTQASG
60 70 80 90 100
DKDIPAINQG LILEETPESS FLIEGDIIRP SPFRLLSATS NKWPMGGSGV
110 120 130 140 150
VEVPFLLSSK YDEPSRQVIL EALAEFERST CIRFVTYQDQ RDFISIIPMY
160 170 180 190 200
GCFSSVGRSG GMQVVSLAPT CLQKGRGIVL HELMHVLGFW HEHTRADRDR
210 220 230 240 250
YIRVNWNEIL PGFEINFIKS RSSNMLTPYD YSSVMHYGRL AFSRRGLPTI
260 270 280 290 300
TPLWAPSVHI GQRWNLSASD ITRVLQLYGC SPSGPRPRGR GSHAHSTGRS
310 320 330 340 350
PAPASLSLQR LLEALSAESR SPDPSGSSAG GQPVPAGPGE SPHGWESPAL
360 370 380 390 400
KKLSAEASAR QPQTLASSPR SRPGAGAPGV AQEQSWLAGV STKPTVPSSE
410 420 430
AGIQPVPVQG SPALPGGCVP RNHFKGMSED
Length:430
Mass (Da):45,833
Last modified:November 21, 2005 - v1
Checksum:i619ED8B901CA279D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107126 mRNA. Translation: AAI07127.1.
UniGeneiHs.447993.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107126 mRNA. Translation: AAI07127.1.
UniGeneiHs.447993.

3D structure databases

ProteinModelPortaliQ3B826.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ3B826.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG080299.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
[Graphical view]
PfamiPF01400. Astacin. 1 hit.
[Graphical view]
PRINTSiPR00480. ASTACIN.
SMARTiSM00235. ZnMc. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiQ3B826_HUMAN
AccessioniPrimary (citable) accession number: Q3B826
Entry historyi
Integrated into UniProtKB/TrEMBL: November 21, 2005
Last sequence update: November 21, 2005
Last modified: March 3, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.