Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Metalloendopeptidase

Gene

ASTL

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, MetalloproteaseUniRule annotation, Protease
LigandMetal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
MetalloendopeptidaseUniRule annotation (EC:3.4.24.-UniRule annotation)
Gene namesi
Name:ASTLImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22UniRule annotationAdd BLAST22
ChainiPRO_500514315223 – 430MetalloendopeptidaseUniRule annotationAdd BLAST408

Proteomic databases

PaxDbiQ3B826.
PeptideAtlasiQ3B826.
PRIDEiQ3B826.

Structurei

3D structure databases

ProteinModelPortaliQ3B826.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini89 – 233ZnMcInterPro annotationAdd BLAST145

Sequence similaritiesi

Belongs to the peptidase M12A family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG3714. Eukaryota.
ENOG410ZPX7. LUCA.
HOVERGENiHBG080299.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiView protein in InterPro
IPR024079. MetalloPept_cat_dom_sf.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
PfamiView protein in Pfam
PF01400. Astacin. 1 hit.
PRINTSiPR00480. ASTACIN.
SMARTiView protein in SMART
SM00235. ZnMc. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q3B826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EGVGGLWPWV LGLLSLPGVI LGAPLASSCA GACGTSFPDG LTPEGTQASG
60 70 80 90 100
DKDIPAINQG LILEETPESS FLIEGDIIRP SPFRLLSATS NKWPMGGSGV
110 120 130 140 150
VEVPFLLSSK YDEPSRQVIL EALAEFERST CIRFVTYQDQ RDFISIIPMY
160 170 180 190 200
GCFSSVGRSG GMQVVSLAPT CLQKGRGIVL HELMHVLGFW HEHTRADRDR
210 220 230 240 250
YIRVNWNEIL PGFEINFIKS RSSNMLTPYD YSSVMHYGRL AFSRRGLPTI
260 270 280 290 300
TPLWAPSVHI GQRWNLSASD ITRVLQLYGC SPSGPRPRGR GSHAHSTGRS
310 320 330 340 350
PAPASLSLQR LLEALSAESR SPDPSGSSAG GQPVPAGPGE SPHGWESPAL
360 370 380 390 400
KKLSAEASAR QPQTLASSPR SRPGAGAPGV AQEQSWLAGV STKPTVPSSE
410 420 430
AGIQPVPVQG SPALPGGCVP RNHFKGMSED
Length:430
Mass (Da):45,833
Last modified:November 22, 2005 - v1
Checksum:i619ED8B901CA279D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107126 mRNA. Translation: AAI07127.1.
UniGeneiHs.447993.

Similar proteinsi

Entry informationi

Entry nameiQ3B826_HUMAN
AccessioniPrimary (citable) accession number: Q3B826
Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2005
Last sequence update: November 22, 2005
Last modified: November 22, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.