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Protein

Transcription elongation regulator 1-like protein

Gene

Tcerg1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation regulator 1-like protein
Gene namesi
Name:Tcerg1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1917821. Tcerg1l.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 590590Transcription elongation regulator 1-like proteinPRO_0000312873Add
BLAST

Proteomic databases

EPDiQ3B807.
PaxDbiQ3B807.
PRIDEiQ3B807.

PTM databases

iPTMnetiQ3B807.
PhosphoSiteiQ3B807.

Expressioni

Gene expression databases

BgeeiQ3B807.
CleanExiMM_TCERG1L.
GenevisibleiQ3B807. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124476.

Structurei

3D structure databases

ProteinModelPortaliQ3B807.
SMRiQ3B807. Positions 150-177, 328-400, 454-579.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini145 – 17834WW 1PROSITE-ProRule annotationAdd
BLAST
Domaini343 – 37634WW 2PROSITE-ProRule annotationAdd
BLAST
Domaini454 – 50754FF 1Add
BLAST
Domaini519 – 57456FF 2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi240 – 24910Poly-Ala

Sequence similaritiesi

Contains 2 FF domains.Curated
Contains 2 WW domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410INXB. Eukaryota.
ENOG410ZEUP. LUCA.
GeneTreeiENSGT00820000127014.
HOGENOMiHOG000170000.
HOVERGENiHBG108553.
InParanoidiQ3B807.
OMAiIDKRIPN.
OrthoDBiEOG7DC24V.
PhylomeDBiQ3B807.
TreeFamiTF317748.

Family and domain databases

Gene3Di1.10.10.440. 2 hits.
InterProiIPR002713. FF_domain.
IPR001202. WW_dom.
[Graphical view]
PfamiPF01846. FF. 2 hits.
[Graphical view]
SMARTiSM00441. FF. 2 hits.
SM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
SSF81698. SSF81698. 2 hits.
PROSITEiPS51676. FF. 2 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3B807-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLAGARLQRR RRQLQQPQQP RWRQPLPWPM NADPPPPPWV WMVPGTAGLL
60 70 80 90 100
RLGAGVAPPP VLLASAQPAS APLLPRLPGW PAPGEPLLPL LPLSSAPDHA
110 120 130 140 150
AVHHYPLLHG QWLFGGHSPS IGLAPSSAVE LVPLFPHVCP STLSPPVGKN
160 170 180 190 200
WIDKRMPNYK IFFNNPFALD STWMYPEESV LFHSHEKTHF LANQVTPSLS
210 220 230 240 250
RPTPASRPLP TVVLAAQPIP GGCHDSLKPI SRGPTITITA ATAAAAATAM
260 270 280 290 300
VSVDPEELRG LSPSIMQPCH FLTLTPIRIP FRTAPFSDKG KEHSRAPRSP
310 320 330 340 350
ALMLRAPERK SLVGDKEDKE PPPILVRGEE TAAKGNKPVA STPVPGSPWC
360 370 380 390 400
VVWTGDDRVF FFNPTMQLSV WEKPVDLQNR GDLKRIIEDP PHKRKLEASA
410 420 430 440 450
TESSDGSSSD DGSEDQSVKT KRNRTESCEG PGPEDTHQVD KGPQTPPPQI
460 470 480 490 500
LLPLEERVTH FRDMLLERGV SAFSTWEKEL HKIVFDPRYL LLNSEERKQI
510 520 530 540 550
FEQFVKTRIK EEYKERKSKL LLAKEEFKKL LEESKVSPRT TFKEFAEKHG
560 570 580 590
RDQRFRLVQK RKDQEHFFNQ FILILKKRDK ENRLRLRKMR
Length:590
Mass (Da):66,376
Last modified:February 26, 2008 - v3
Checksum:iAB869DB42F835F91
GO
Isoform 2 (identifier: Q3B807-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     401-402: TE → SN
     403-590: Missing.

Note: No experimental confirmation available.
Show »
Length:402
Mass (Da):43,891
Checksum:iFCDFFB41DD69A26D
GO
Isoform 3 (identifier: Q3B807-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-365: Missing.

Note: No experimental confirmation available.
Show »
Length:225
Mass (Da):26,786
Checksum:i94689A1D2B780753
GO

Sequence cautioni

The sequence AAH48631.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAI07235.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI07236.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC25528.1 differs from that shown. Reason: Frameshift at position 27. Curated
The sequence BAC25528.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti294 – 2941S → R in BAC25528 (PubMed:16141072).Curated
Sequence conflicti322 – 3221P → S in BAC25528 (PubMed:16141072).Curated
Sequence conflicti337 – 3371K → N in BAC25528 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 365365Missing in isoform 3. 1 PublicationVSP_029925Add
BLAST
Alternative sequencei401 – 4022TE → SN in isoform 2. 2 PublicationsVSP_029926
Alternative sequencei403 – 590188Missing in isoform 2. 2 PublicationsVSP_029927Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC127598 Genomic DNA. No translation available.
AC127287 Genomic DNA. No translation available.
AK017700 mRNA. Translation: BAC25528.1. Sequence problems.
BC048631 mRNA. Translation: AAH48631.1. Sequence problems.
BC107234 mRNA. Translation: AAI07235.1. Different initiation.
BC107235 mRNA. Translation: AAI07236.1. Different initiation.
CCDSiCCDS40167.2. [Q3B807-1]
RefSeqiNP_899112.2. NM_183289.3. [Q3B807-1]
UniGeneiMm.334297.

Genome annotation databases

EnsembliENSMUST00000160436; ENSMUSP00000124476; ENSMUSG00000091002. [Q3B807-1]
GeneIDi70571.
KEGGimmu:70571.
UCSCiuc009kez.1. mouse. [Q3B807-2]
uc012fvn.1. mouse. [Q3B807-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC127598 Genomic DNA. No translation available.
AC127287 Genomic DNA. No translation available.
AK017700 mRNA. Translation: BAC25528.1. Sequence problems.
BC048631 mRNA. Translation: AAH48631.1. Sequence problems.
BC107234 mRNA. Translation: AAI07235.1. Different initiation.
BC107235 mRNA. Translation: AAI07236.1. Different initiation.
CCDSiCCDS40167.2. [Q3B807-1]
RefSeqiNP_899112.2. NM_183289.3. [Q3B807-1]
UniGeneiMm.334297.

3D structure databases

ProteinModelPortaliQ3B807.
SMRiQ3B807. Positions 150-177, 328-400, 454-579.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124476.

PTM databases

iPTMnetiQ3B807.
PhosphoSiteiQ3B807.

Proteomic databases

EPDiQ3B807.
PaxDbiQ3B807.
PRIDEiQ3B807.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000160436; ENSMUSP00000124476; ENSMUSG00000091002. [Q3B807-1]
GeneIDi70571.
KEGGimmu:70571.
UCSCiuc009kez.1. mouse. [Q3B807-2]
uc012fvn.1. mouse. [Q3B807-1]

Organism-specific databases

CTDi256536.
MGIiMGI:1917821. Tcerg1l.

Phylogenomic databases

eggNOGiENOG410INXB. Eukaryota.
ENOG410ZEUP. LUCA.
GeneTreeiENSGT00820000127014.
HOGENOMiHOG000170000.
HOVERGENiHBG108553.
InParanoidiQ3B807.
OMAiIDKRIPN.
OrthoDBiEOG7DC24V.
PhylomeDBiQ3B807.
TreeFamiTF317748.

Miscellaneous databases

ChiTaRSiTcerg1l. mouse.
PROiQ3B807.
SOURCEiSearch...

Gene expression databases

BgeeiQ3B807.
CleanExiMM_TCERG1L.
GenevisibleiQ3B807. MM.

Family and domain databases

Gene3Di1.10.10.440. 2 hits.
InterProiIPR002713. FF_domain.
IPR001202. WW_dom.
[Graphical view]
PfamiPF01846. FF. 2 hits.
[Graphical view]
SMARTiSM00441. FF. 2 hits.
SM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
SSF81698. SSF81698. 2 hits.
PROSITEiPS51676. FF. 2 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Embryo.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 104-590 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-581 (ISOFORM 3).

Entry informationi

Entry nameiTCRGL_MOUSE
AccessioniPrimary (citable) accession number: Q3B807
Secondary accession number(s): Q80ZP6, Q8BT57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: February 26, 2008
Last modified: June 8, 2016
This is version 77 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.