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Protein

Peptidyl-prolyl cis-trans isomerase FKBP8

Gene

Fkbp8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis (By similarity).By similarity

Miscellaneous

Binds the immunosuppressant FK506 only in its calmodulin/calcium activated form.By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Cofactori

Ca2+By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Rotamase
Biological processApoptosis
LigandCalcium

Enzyme and pathway databases

ReactomeiR-RNO-5689880 Ub-specific processing proteases

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP8 (EC:5.2.1.8)
Short name:
PPIase FKBP8
Alternative name(s):
FK506-binding protein 8
Short name:
FKBP-8
Rotamase
Gene namesi
Name:Fkbp8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi1308670 Fkbp8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003425301 – 403Peptidyl-prolyl cis-trans isomerase FKBP8Add BLAST403

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki240Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki262Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki264Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki275Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei287PhosphoserineBy similarity1
Cross-linki298Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki305Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki325Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki331Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki339Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki342Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki343Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ3B7U9
PRIDEiQ3B7U9

PTM databases

iPTMnetiQ3B7U9
PhosphoSitePlusiQ3B7U9

Expressioni

Gene expression databases

BgeeiENSRNOG00000058359
GenevisibleiQ3B7U9 RN

Interactioni

Subunit structurei

Homomultimers or heteromultimers (Potential). Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCLX isoform Bcl-X(L). Does not bind and inhibit calcineurin. Interacts with ZFYVE27; may negatively regulate ZFYVE27 phosphorylation (By similarity).By similarityCurated

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027040

Structurei

3D structure databases

ProteinModelPortaliQ3B7U9
SMRiQ3B7U9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini110 – 195PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST86
Repeati212 – 245TPR 1Add BLAST34
Repeati263 – 296TPR 2Add BLAST34
Repeati297 – 330TPR 3Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi253 – 257Poly-Glu5

Keywords - Domaini

Repeat, TPR repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0543 Eukaryota
COG0545 LUCA
GeneTreeiENSGT00910000144255
HOGENOMiHOG000112604
HOVERGENiHBG051626
InParanoidiQ3B7U9
KOiK09574
OMAiAIYRYKY
OrthoDBiEOG091G0AS2
PhylomeDBiQ3B7U9
TreeFamiTF105295

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR023566 PPIase_FKBP
IPR001179 PPIase_FKBP_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR10516 PTHR10516, 1 hit
PfamiView protein in Pfam
PF00254 FKBP_C, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50059 FKBP_PPIASE, 1 hit
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q3B7U9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASWAEPSEP AAQLLCGAPL LEGFEVLDGV DDAEEEDDLS GLPPLEDMGQ
60 70 80 90 100
PTVEEAEQPG ALAREFLAAT EPEPAPAPAP EEWLDILGNG LLRKKTLVPG
110 120 130 140 150
PTGSSRPLKG QVVTVHLQMS LENGTRVQEE PELAFTLGDC DVIQALDLSV
160 170 180 190 200
PLMHVGETAM VTADSKYCYG PQGSRSPYIP PHAALCLEVT LKTAEDGPDL
210 220 230 240 250
EMLSGQERVA LANRKRECGN AHYQRADFVL AANSYDLAIK AITSNAKVDM
260 270 280 290 300
TCEEEEELLQ LKVKCLNNLA ASQLKLDHYR AALRSCSQVL EHQPDNIKAL
310 320 330 340 350
FRKGKVLAQQ GEYSEAIPIL RAALKLEPSN KTIHAELSKL VKKRAAQRST
360 370 380 390 400
ETALYRKMLG NPSRLPAKCP GKGAWSIPWK WLFGATAVAL GGVALSVVIA

ARN
Length:403
Mass (Da):43,556
Last modified:November 22, 2005 - v1
Checksum:iF4E65E70D6155929
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107454 mRNA Translation: AAI07455.1
RefSeqiNP_001032257.1, NM_001037180.1
UniGeneiRn.99789

Genome annotation databases

EnsembliENSRNOT00000077756; ENSRNOP00000074539; ENSRNOG00000058359
GeneIDi290652
KEGGirno:290652
UCSCiRGD:1308670 rat

Similar proteinsi

Entry informationi

Entry nameiFKBP8_RAT
AccessioniPrimary (citable) accession number: Q3B7U9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: November 22, 2005
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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