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Protein

Peptidyl-prolyl cis-trans isomerase FKBP8

Gene

Fkbp8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis (By similarity).By similarity

Miscellaneous

Binds the immunosuppressant FK506 only in its calmodulin/calcium activated form.By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Cofactori

Ca2+By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Rotamase
Biological processApoptosis
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP8 (EC:5.2.1.8)
Short name:
PPIase FKBP8
Alternative name(s):
FK506-binding protein 8
Short name:
FKBP-8
Rotamase
Gene namesi
Name:Fkbp8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi1308670. Fkbp8.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003425301 – 403Peptidyl-prolyl cis-trans isomerase FKBP8Add BLAST403

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki240Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki262Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki264Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki275Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei287PhosphoserineBy similarity1
Cross-linki298Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki305Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki325Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki331Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki339Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki342Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki343Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ3B7U9.
PRIDEiQ3B7U9.

PTM databases

iPTMnetiQ3B7U9.
PhosphoSitePlusiQ3B7U9.

Expressioni

Gene expression databases

BgeeiENSRNOG00000058359.
GenevisibleiQ3B7U9. RN.

Interactioni

Subunit structurei

Homomultimers or heteromultimers (Potential). Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCLX isoform Bcl-X(L). Does not bind and inhibit calcineurin. Interacts with ZFYVE27; may negatively regulate ZFYVE27 phosphorylation (By similarity).By similarityCurated

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027040.

Structurei

3D structure databases

ProteinModelPortaliQ3B7U9.
SMRiQ3B7U9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini110 – 195PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST86
Repeati212 – 245TPR 1Add BLAST34
Repeati263 – 296TPR 2Add BLAST34
Repeati297 – 330TPR 3Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi253 – 257Poly-Glu5

Keywords - Domaini

Repeat, TPR repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0543. Eukaryota.
COG0545. LUCA.
GeneTreeiENSGT00880000138035.
HOGENOMiHOG000112604.
HOVERGENiHBG051626.
InParanoidiQ3B7U9.
KOiK09574.
OMAiAIYRYKY.
OrthoDBiEOG091G0AS2.
PhylomeDBiQ3B7U9.
TreeFamiTF105295.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiView protein in InterPro
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiView protein in Pfam
PF00254. FKBP_C. 1 hit.
SMARTiView protein in SMART
SM00028. TPR. 3 hits.
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiView protein in PROSITE
PS50059. FKBP_PPIASE. 1 hit.
PS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3B7U9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASWAEPSEP AAQLLCGAPL LEGFEVLDGV DDAEEEDDLS GLPPLEDMGQ
60 70 80 90 100
PTVEEAEQPG ALAREFLAAT EPEPAPAPAP EEWLDILGNG LLRKKTLVPG
110 120 130 140 150
PTGSSRPLKG QVVTVHLQMS LENGTRVQEE PELAFTLGDC DVIQALDLSV
160 170 180 190 200
PLMHVGETAM VTADSKYCYG PQGSRSPYIP PHAALCLEVT LKTAEDGPDL
210 220 230 240 250
EMLSGQERVA LANRKRECGN AHYQRADFVL AANSYDLAIK AITSNAKVDM
260 270 280 290 300
TCEEEEELLQ LKVKCLNNLA ASQLKLDHYR AALRSCSQVL EHQPDNIKAL
310 320 330 340 350
FRKGKVLAQQ GEYSEAIPIL RAALKLEPSN KTIHAELSKL VKKRAAQRST
360 370 380 390 400
ETALYRKMLG NPSRLPAKCP GKGAWSIPWK WLFGATAVAL GGVALSVVIA

ARN
Length:403
Mass (Da):43,556
Last modified:November 22, 2005 - v1
Checksum:iF4E65E70D6155929
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107454 mRNA. Translation: AAI07455.1.
RefSeqiNP_001032257.1. NM_001037180.1.
UniGeneiRn.99789.

Genome annotation databases

EnsembliENSRNOT00000077756; ENSRNOP00000074539; ENSRNOG00000058359.
GeneIDi290652.
KEGGirno:290652.
UCSCiRGD:1308670. rat.

Similar proteinsi

Entry informationi

Entry nameiFKBP8_RAT
AccessioniPrimary (citable) accession number: Q3B7U9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: November 22, 2005
Last modified: August 30, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome