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Protein

Rab11 family-interacting protein 1

Gene

Rab11fip1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and phagocytosis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Rab11 family-interacting protein 1
Short name:
Rab11-FIP1
Alternative name(s):
Rab-coupling protein
Gene namesi
Name:Rab11fip1By similarity
Synonyms:RcpBy similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi1562965. Rab11fip1.

Subcellular locationi

  • Recycling endosome By similarity
  • Cytoplasmic vesiclephagosome membrane By similarity

  • Note: Membrane-bound. RAB11A rather than RAB4A mediates RAB11FIP1 localization in the endocytic recycling compartment (ERC). Colocalizes with RAB11A at phagosomes (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 648648Rab11 family-interacting protein 1PRO_0000234531Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei205 – 2051PhosphoserineCombined sources
Modified residuei209 – 2091PhosphoserineBy similarity
Modified residuei237 – 2371PhosphoserineBy similarity
Modified residuei304 – 3041PhosphoserineBy similarity
Modified residuei319 – 3191PhosphoserineBy similarity
Modified residuei343 – 3431PhosphoserineBy similarity
Modified residuei345 – 3451PhosphoserineBy similarity
Modified residuei347 – 3471PhosphoserineCombined sources
Modified residuei349 – 3491PhosphoserineCombined sources
Modified residuei360 – 3601PhosphoserineBy similarity
Modified residuei361 – 3611PhosphoserineCombined sources
Modified residuei386 – 3861PhosphoserineBy similarity
Modified residuei438 – 4381PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ3B7T9.

PTM databases

iPTMnetiQ3B7T9.

Expressioni

Gene expression databases

ExpressionAtlasiQ3B7T9. differential.
GenevisibleiQ3B7T9. RN.

Interactioni

Subunit structurei

Homooligomer. Interacts with RAB4A, RAB11A, RAB11B and RAB25 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ3B7T9. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ3B7T9.
SMRiQ3B7T9. Positions 586-640.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 111107C2PROSITE-ProRule annotationAdd
BLAST
Domaini576 – 63863FIP-RBDPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni584 – 64865Necessary for interaction with RAB4A and RAB11A, subcellular location and endosomal recyclingBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi212 – 22110Poly-LysSequence analysis

Sequence similaritiesi

Contains 1 C2 domain.PROSITE-ProRule annotation
Contains 1 FIP-RBD domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000063203.
HOGENOMiHOG000234700.
HOVERGENiHBG079127.
InParanoidiQ3B7T9.
KOiK12484.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR019018. Rab-bd_FIP-RBD.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF09457. RBD-FIP. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS51511. FIP_RBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3B7T9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLAASAGRG PGTMWSPTHV QVTVLQARGL RAKGPGGTSD AYAVIQVGKE
60 70 80 90 100
KYATSVSERS LGAPVWREEA TFELPPLLSS GTAPAAAAAT LQLTVLHRAL
110 120 130 140 150
LGLDKFLGRA EVDLRELHRD QSRRKKQWYT LKSKPGKKDK ERGEIEVDIQ
160 170 180 190 200
FMRNNMTASM FDLSMKDKSR NPFGKLKDKI KGKNKDNTSD TASAIVPSTT
210 220 230 240 250
PSVDSDDESF SKDKKKKSKI KTLFSKPSLQ KTPLSQSMSV LPTSKPDKVL
260 270 280 290 300
LRPGDFQSRW GDEGDNEDES SSASEVMSQK RTSSTDHTQP NQSNFSLPKK
310 320 330 340 350
EGLSFLGGLR SKNDSLSRSN VCINGNHVYM EQPEAKSEIR ESSPSNSPSP
360 370 380 390 400
QGFRKRHLFS STENLAARSP KEPGEGGGMS SDRRLSDSST KDSMKSMSLP
410 420 430 440 450
SYRPLTTADS REGLSPANME VATKETKDSK KQESKKSSLL SLVTGKKDVA
460 470 480 490 500
KGSEGEPLPP VSEKEKGRKG VLVEAQLREE DLVRRPEKDA VPVASQWGSS
510 520 530 540 550
QNPFEDAQIS DLEASVESKC EPKPPVPVPR TPQTRAVKPR PHPVKPMNTT
560 570 580 590 600
APKITNSSLG TATIISENLI NEALMKKYQP SDPAFAYAQL THDELIQLVL
610 620 630 640
KQKETISKKE FQVRELEDYI DNLLVRVMEE TPNILRVPAQ TGKKAGKM
Length:648
Mass (Da):71,143
Last modified:November 22, 2005 - v1
Checksum:iA4C70DDB1A540F3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107469 mRNA. Translation: AAI07470.1.
RefSeqiNP_001178484.1. NM_001191555.1.
NP_001184170.1. NM_001197241.1.
UniGeneiRn.49288.

Genome annotation databases

EnsembliENSRNOT00000086082; ENSRNOP00000073557; ENSRNOG00000058940.
GeneIDi498650.
KEGGirno:498650.
UCSCiRGD:1562965. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107469 mRNA. Translation: AAI07470.1.
RefSeqiNP_001178484.1. NM_001191555.1.
NP_001184170.1. NM_001197241.1.
UniGeneiRn.49288.

3D structure databases

ProteinModelPortaliQ3B7T9.
SMRiQ3B7T9. Positions 586-640.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3B7T9. 1 interaction.

PTM databases

iPTMnetiQ3B7T9.

Proteomic databases

PRIDEiQ3B7T9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000086082; ENSRNOP00000073557; ENSRNOG00000058940.
GeneIDi498650.
KEGGirno:498650.
UCSCiRGD:1562965. rat.

Organism-specific databases

CTDi80223.
RGDi1562965. Rab11fip1.

Phylogenomic databases

GeneTreeiENSGT00530000063203.
HOGENOMiHOG000234700.
HOVERGENiHBG079127.
InParanoidiQ3B7T9.
KOiK12484.

Miscellaneous databases

PROiQ3B7T9.

Gene expression databases

ExpressionAtlasiQ3B7T9. differential.
GenevisibleiQ3B7T9. RN.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR019018. Rab-bd_FIP-RBD.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF09457. RBD-FIP. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS51511. FIP_RBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-205; SER-347; SER-349 AND SER-361, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRFIP1_RAT
AccessioniPrimary (citable) accession number: Q3B7T9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: November 22, 2005
Last modified: July 6, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.