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Q3B7T6

- CNEP1_RAT

UniProt

Q3B7T6 - CNEP1_RAT

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Protein

CTD nuclear envelope phosphatase 1

Gene

Ctdnep1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. protein serine/threonine phosphatase activity Source: UniProtKB

GO - Biological processi

  1. gamete generation Source: Ensembl
  2. mesoderm development Source: Ensembl
  3. nuclear envelope organization Source: UniProtKB
  4. positive regulation of canonical Wnt signaling pathway Source: Ensembl
  5. positive regulation of triglyceride biosynthetic process Source: UniProtKB
  6. protein dephosphorylation Source: UniProtKB
  7. protein localization to nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiREACT_202734. Depolymerisation of the Nuclear Lamina.

Names & Taxonomyi

Protein namesi
Recommended name:
CTD nuclear envelope phosphatase 1 (EC:3.1.3.16)
Alternative name(s):
Serine/threonine-protein phosphatase dullard
Gene namesi
Name:Ctdnep1
Synonyms:Dullard
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi1310172. Ctdnep1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2923HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. endoplasmic reticulum membrane Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
  4. Nem1-Spo7 phosphatase complex Source: UniProtKB
  5. nuclear envelope Source: UniProtKB
  6. nuclear membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 244244CTD nuclear envelope phosphatase 1PRO_0000297969Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriQ3B7T6.

Interactioni

Subunit structurei

Interacts with CNEP1R1; the complex dephosphorylates LPIN1 and LPIN2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023379.

Structurei

3D structure databases

ProteinModelPortaliQ3B7T6.
SMRiQ3B7T6. Positions 57-234.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini57 – 224168FCP1 homologyPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the dullard family.Curated
Contains 1 FCP1 homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5190.
GeneTreeiENSGT00550000075053.
HOVERGENiHBG098153.
InParanoidiQ3B7T6.
KOiK17617.
OMAiLLGIRTF.
OrthoDBiEOG7MKW6W.
PhylomeDBiQ3B7T6.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR011948. Dullard_phosphatase.
IPR023214. HAD-like_dom.
IPR004274. NIF.
[Graphical view]
PfamiPF03031. NIF. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02251. HIF-SF_euk. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3B7T6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMRTQCLLGL RTFVAFAAKL WSFFIYLLRR QIRTVIQYQT VRYDILPLSP
60 70 80 90 100
LSRNRLAQVK RKILVLDLDE TLIHSHHDGV LRPTVRPGTP PDFILKVVID
110 120 130 140 150
KHPVRFFVHK RPHVDFFLEV VSQWYELVVF TASMEIYGSA VADKLDNSRS
160 170 180 190 200
ILKRRYYRQH CTLELGSYIK DLSVVHSDLS SIVILDNSPG AYRSHPDNAI
210 220 230 240
PIKSWFSDPS DTALLNLLPM LDALRFTADV RSVLSRNLHQ HRLW
Length:244
Mass (Da):28,391
Last modified:August 21, 2007 - v2
Checksum:i1AD25540018F50BA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti119 – 1191E → K in BU671232. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BU671232 mRNA. No translation available.
BC087638 mRNA. Translation: AAH87638.1.
BC107474 mRNA. Translation: AAI07475.1.
RefSeqiNP_001093964.1. NM_001100494.1.
UniGeneiRn.4211.

Genome annotation databases

EnsembliENSRNOT00000023379; ENSRNOP00000023379; ENSRNOG00000017352.
GeneIDi287447.
KEGGirno:287447.
UCSCiRGD:1310172. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BU671232 mRNA. No translation available.
BC087638 mRNA. Translation: AAH87638.1 .
BC107474 mRNA. Translation: AAI07475.1 .
RefSeqi NP_001093964.1. NM_001100494.1.
UniGenei Rn.4211.

3D structure databases

ProteinModelPortali Q3B7T6.
SMRi Q3B7T6. Positions 57-234.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000023379.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000023379 ; ENSRNOP00000023379 ; ENSRNOG00000017352 .
GeneIDi 287447.
KEGGi rno:287447.
UCSCi RGD:1310172. rat.

Organism-specific databases

CTDi 23399.
RGDi 1310172. Ctdnep1.

Phylogenomic databases

eggNOGi COG5190.
GeneTreei ENSGT00550000075053.
HOVERGENi HBG098153.
InParanoidi Q3B7T6.
KOi K17617.
OMAi LLGIRTF.
OrthoDBi EOG7MKW6W.
PhylomeDBi Q3B7T6.

Enzyme and pathway databases

Reactomei REACT_202734. Depolymerisation of the Nuclear Lamina.

Miscellaneous databases

NextBioi 626170.
PROi Q3B7T6.

Gene expression databases

Genevestigatori Q3B7T6.

Family and domain databases

Gene3Di 3.40.50.1000. 1 hit.
InterProi IPR011948. Dullard_phosphatase.
IPR023214. HAD-like_dom.
IPR004274. NIF.
[Graphical view ]
Pfami PF03031. NIF. 1 hit.
[Graphical view ]
SMARTi SM00577. CPDc. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR02251. HIF-SF_euk. 1 hit.
PROSITEi PS50969. FCP1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary, Placenta and Prostate.

Entry informationi

Entry nameiCNEP1_RAT
AccessioniPrimary (citable) accession number: Q3B7T6
Secondary accession number(s): Q5M952
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: October 29, 2014
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3