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Q3B7T6 (CNEP1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CTD nuclear envelope phosphatase 1

EC=3.1.3.16
Alternative name(s):
Serine/threonine-protein phosphatase dullard
Gene names
Name:Ctdnep1
Synonyms:Dullard
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length244 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subunit structure

Interacts with CNEP1R1; the complex dephosphorylates LPIN1 and LPIN2 By similarity.

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane protein By similarity. Nucleus membrane; Single-pass membrane protein By similarity.

Sequence similarities

Belongs to the dullard family.

Contains 1 FCP1 homology domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 244244CTD nuclear envelope phosphatase 1
PRO_0000297969

Regions

Transmembrane7 – 2923Helical; Potential
Domain57 – 224168FCP1 homology

Experimental info

Sequence conflict1191E → K in BU671232. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q3B7T6 [UniParc].

Last modified August 21, 2007. Version 2.
Checksum: 1AD25540018F50BA

FASTA24428,391
        10         20         30         40         50         60 
MMRTQCLLGL RTFVAFAAKL WSFFIYLLRR QIRTVIQYQT VRYDILPLSP LSRNRLAQVK 

        70         80         90        100        110        120 
RKILVLDLDE TLIHSHHDGV LRPTVRPGTP PDFILKVVID KHPVRFFVHK RPHVDFFLEV 

       130        140        150        160        170        180 
VSQWYELVVF TASMEIYGSA VADKLDNSRS ILKRRYYRQH CTLELGSYIK DLSVVHSDLS 

       190        200        210        220        230        240 
SIVILDNSPG AYRSHPDNAI PIKSWFSDPS DTALLNLLPM LDALRFTADV RSVLSRNLHQ 


HRLW 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary, Placenta and Prostate.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BU671232 mRNA. No translation available.
BC087638 mRNA. Translation: AAH87638.1.
BC107474 mRNA. Translation: AAI07475.1.
RefSeqNP_001093964.1. NM_001100494.1.
UniGeneRn.4211.

3D structure databases

ProteinModelPortalQ3B7T6.
SMRQ3B7T6. Positions 57-234.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000023379.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000023379; ENSRNOP00000023379; ENSRNOG00000017352.
GeneID287447.
KEGGrno:287447.
UCSCRGD:1310172. rat.

Organism-specific databases

CTD23399.
RGD1310172. Ctdnep1.

Phylogenomic databases

eggNOGCOG5190.
GeneTreeENSGT00550000075053.
HOVERGENHBG098153.
InParanoidQ3B7T6.
KOK17617.
OMALLGIRTF.
OrthoDBEOG7MKW6W.
PhylomeDBQ3B7T6.

Gene expression databases

GenevestigatorQ3B7T6.

Family and domain databases

Gene3D3.40.50.1000. 1 hit.
InterProIPR011948. Dullard_phosphatase.
IPR023214. HAD-like_dom.
IPR004274. NIF.
[Graphical view]
PfamPF03031. NIF. 1 hit.
[Graphical view]
SMARTSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMSSF56784. SSF56784. 1 hit.
TIGRFAMsTIGR02251. HIF-SF_euk. 1 hit.
PROSITEPS50969. FCP1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio626170.
PROQ3B7T6.

Entry information

Entry nameCNEP1_RAT
AccessionPrimary (citable) accession number: Q3B7T6
Secondary accession number(s): Q5M952
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: June 11, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families