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Protein

Small integral membrane protein 21

Gene

SMIM21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Names & Taxonomyi

Protein namesi
Recommended name:
Small integral membrane protein 21
Gene namesi
Name:SMIM21
Synonyms:C18orf62
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:27598. SMIM21.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei49 – 6517HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162378613.

Polymorphism and mutation databases

BioMutaiSMIM21.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 101101Small integral membrane protein 21PRO_0000340722Add
BLAST

Proteomic databases

PaxDbiQ3B7S5.
PRIDEiQ3B7S5.

Expressioni

Gene expression databases

BgeeiQ3B7S5.
CleanExiHS_C18orf62.
ExpressionAtlasiQ3B7S5. baseline and differential.
GenevisibleiQ3B7S5. HS.

Organism-specific databases

HPAiHPA041686.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000462106.

Structurei

3D structure databases

ProteinModelPortaliQ3B7S5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG135016.
GeneTreeiENSGT00410000028836.
HOGENOMiHOG000111963.
InParanoidiQ3B7S5.
OMAiQGVSEDW.
OrthoDBiEOG7N63Q1.
PhylomeDBiQ3B7S5.

Sequencei

Sequence statusi: Complete.

Q3B7S5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQYVSTAPP RFPIAQLGTF KQDSAGMGRI FKGNLLQKKA LTTFENEHHI
60 70 80 90 100
RFFTLLVLFH VMVLLRNHSR IQGVSEDWKR ANSIFRNFLR LKSSRNTAEA

E
Length:101
Mass (Da):11,722
Last modified:November 22, 2005 - v1
Checksum:i82E93FA8AFB9C6C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107486 mRNA. Translation: AAI07487.1.
CCDSiCCDS32845.1.
RefSeqiNP_001032408.1. NM_001037331.3.
UniGeneiHs.666744.

Genome annotation databases

EnsembliENST00000579022; ENSP00000462106; ENSG00000206026.
GeneIDi284274.
KEGGihsa:284274.
UCSCiuc002lma.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107486 mRNA. Translation: AAI07487.1.
CCDSiCCDS32845.1.
RefSeqiNP_001032408.1. NM_001037331.3.
UniGeneiHs.666744.

3D structure databases

ProteinModelPortaliQ3B7S5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000462106.

Polymorphism and mutation databases

BioMutaiSMIM21.

Proteomic databases

PaxDbiQ3B7S5.
PRIDEiQ3B7S5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000579022; ENSP00000462106; ENSG00000206026.
GeneIDi284274.
KEGGihsa:284274.
UCSCiuc002lma.1. human.

Organism-specific databases

CTDi284274.
GeneCardsiGC18M073122.
HGNCiHGNC:27598. SMIM21.
HPAiHPA041686.
neXtProtiNX_Q3B7S5.
PharmGKBiPA162378613.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG135016.
GeneTreeiENSGT00410000028836.
HOGENOMiHOG000111963.
InParanoidiQ3B7S5.
OMAiQGVSEDW.
OrthoDBiEOG7N63Q1.
PhylomeDBiQ3B7S5.

Miscellaneous databases

GenomeRNAii284274.
NextBioi94687.
PROiQ3B7S5.

Gene expression databases

BgeeiQ3B7S5.
CleanExiHS_C18orf62.
ExpressionAtlasiQ3B7S5. baseline and differential.
GenevisibleiQ3B7S5. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiSMI21_HUMAN
AccessioniPrimary (citable) accession number: Q3B7S5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: November 22, 2005
Last modified: July 22, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.