Q3B7S5 (SMI21_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Small integral membrane protein 21

Gene names

Name:	SMIM21
Synonyms:	C18orf62

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	101 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 101	101	Small integral membrane protein 21		PRO_0000340722
Regions
	Transmembrane	49 – 65	17	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q3B7S5 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 82E93FA8AFB9C6C7	FASTA	101	11,722
	10 20 30 40 50 60 MDQYVSTAPP RFPIAQLGTF KQDSAGMGRI FKGNLLQKKA LTTFENEHHI RFFTLLVLFH 70 80 90 100 VMVLLRNHSR IQGVSEDWKR ANSIFRNFLR LKSSRNTAEA E

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC107486 mRNA. Translation: AAI07487.1.
IPI	IPI00401586.
RefSeq	NP_001032408.1. NM_001037331.2.
UniGene	Hs.666744.
3D structure databases
ProteinModelPortal	Q3B7S5.
ModBase	Search...
Proteomic databases
PaxDb	Q3B7S5.
PRIDE	Q3B7S5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000579022; ENSP00000462106; ENSG00000206026.
GeneID	284274.
KEGG	hsa:284274.
UCSC	uc002lma.1. human.
Organism-specific databases
CTD	284274.
GeneCards	GC18M073121.
HGNC	HGNC:27598. SMIM21.
HPA	CAB034243. HPA041686.
neXtProt	NX_Q3B7S5.
PharmGKB	PA162378613.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG135016.
HOGENOM	HOG000111963.
InParanoid	Q3B7S5.
OMA	ENEHHIR.
OrthoDB	EOG473PSV.
Gene expression databases
Bgee	Q3B7S5.
CleanEx	HS_C18orf62.
Genevestigator	Q3B7S5.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	284274.
NextBio	94687.

Entry information

Entry name

SMI21_HUMAN

Accession

Primary (citable) accession number: Q3B7S5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	November 22, 2005
Last modified:	May 1, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.