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Protein
Submitted name:

Ubiquitin A-52 residue ribosomal protein fusion product 1

Gene

uba52

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal proteinImported

Enzyme and pathway databases

ReactomeiR-DRE-110312. Translesion synthesis by REV1.
R-DRE-110314. Recognition of DNA damage by PCNA-containing replication complex.
R-DRE-110320. Translesion Synthesis by POLH.
R-DRE-1169091. Activation of NF-kappaB in B cells.
R-DRE-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-DRE-1253288. Downregulation of ERBB4 signaling.
R-DRE-1295596. Spry regulation of FGF signaling.
R-DRE-1358803. Downregulation of ERBB2:ERBB3 signaling.
R-DRE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DRE-168638. NOD1/2 Signaling Pathway.
R-DRE-174048. APC/C:Cdc20 mediated degradation of Cyclin B.
R-DRE-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-DRE-174154. APC/C:Cdc20 mediated degradation of Securin.
R-DRE-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-DRE-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-DRE-179409. APC-Cdc20 mediated degradation of Nek2A.
R-DRE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DRE-182971. EGFR downregulation.
R-DRE-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-DRE-195253. Degradation of beta-catenin by the destruction complex.
R-DRE-201681. TCF dependent signaling in response to WNT.
R-DRE-202424. Downstream TCR signaling.
R-DRE-209543. p75NTR recruits signalling complexes.
R-DRE-209560. NF-kB is activated and signals survival.
R-DRE-2122948. Activated NOTCH1 Transmits Signal to the Nucleus.
R-DRE-2173788. Downregulation of TGF-beta receptor signaling.
R-DRE-2173791. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
R-DRE-2173795. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
R-DRE-2173796. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
R-DRE-2467813. Separation of Sister Chromatids.
R-DRE-2559580. Oxidative Stress Induced Senescence.
R-DRE-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-DRE-2559585. Oncogene Induced Senescence.
R-DRE-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-DRE-2871837. FCERI mediated NF-kB activation.
R-DRE-3134975. Regulation of innate immune responses to cytosolic DNA.
R-DRE-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-DRE-3769402. Deactivation of the beta-catenin transactivating complex.
R-DRE-382556. ABC-family proteins mediated transport.
R-DRE-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-DRE-446652. Interleukin-1 signaling.
R-DRE-450302. activated TAK1 mediates p38 MAPK activation.
R-DRE-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
R-DRE-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-DRE-4608870. Asymmetric localization of PCP proteins.
R-DRE-4641257. Degradation of AXIN.
R-DRE-4641258. Degradation of DVL.
R-DRE-4641263. Regulation of FZD by ubiquitination.
R-DRE-5205685. Pink/Parkin Mediated Mitophagy.
R-DRE-532668. N-glycan trimming in the ER and Calnexin/Calreticulin cycle.
R-DRE-5357905. Regulation of TNFR1 signaling.
R-DRE-5357956. TNFR1-induced NFkappaB signaling pathway.
R-DRE-5358346. Hedgehog ligand biogenesis.
R-DRE-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-DRE-5607764. CLEC7A (Dectin-1) signaling.
R-DRE-5610785. GLI3 is processed to GLI3R by the proteasome.
R-DRE-5632684. Hedgehog 'on' state.
R-DRE-5654726. Negative regulation of FGFR1 signaling.
R-DRE-5654727. Negative regulation of FGFR2 signaling.
R-DRE-5654732. Negative regulation of FGFR3 signaling.
R-DRE-5654733. Negative regulation of FGFR4 signaling.
R-DRE-5655862. Translesion synthesis by POLK.
R-DRE-5656121. Translesion synthesis by POLI.
R-DRE-5656169. Termination of translesion DNA synthesis.
R-DRE-5658442. Regulation of RAS by GAPs.
R-DRE-5668541. TNFR2 non-canonical NF-kB pathway.
R-DRE-5675221. Negative regulation of MAPK pathway.
R-DRE-5675482. Regulation of necroptotic cell death.
R-DRE-5676590. NIK-->noncanonical NF-kB signaling.
R-DRE-5684264. MAP3K8 (TPL2)-dependent MAPK1/3 activation.
R-DRE-5685942. HDR through Homologous Recombination (HRR).
R-DRE-5687128. MAPK6/MAPK4 signaling.
R-DRE-5689603. UCH proteinases.
R-DRE-5689877. Josephin domain DUBs.
R-DRE-5689880. Ub-specific processing proteases.
R-DRE-5689896. Ovarian tumor domain proteases.
R-DRE-5689901. Metalloprotease DUBs.
R-DRE-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-DRE-5696394. DNA Damage Recognition in GG-NER.
R-DRE-5696395. Formation of Incision Complex in GG-NER.
R-DRE-5696397. Gap-filling DNA repair synthesis and ligation in GG-NER.
R-DRE-5696400. Dual Incision in GG-NER.
R-DRE-6781823. Formation of TC-NER Pre-Incision Complex.
R-DRE-6782135. Dual incision in TC-NER.
R-DRE-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-DRE-6783310. Fanconi Anemia Pathway.
R-DRE-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-DRE-6804756. Regulation of TP53 Activity through Phosphorylation.
R-DRE-6804757. Regulation of TP53 Degradation.
R-DRE-6807004. Negative regulation of MET activity.
R-DRE-68827. CDT1 association with the CDC6:ORC:origin complex.
R-DRE-68949. Orc1 removal from chromatin.
R-DRE-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-DRE-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-DRE-69231. Cyclin D associated events in G1.
R-DRE-69298. Association of licensing factors with the pre-replicative complex.
R-DRE-69481. G2/M Checkpoints.
R-DRE-69541. Stabilization of p53.
R-DRE-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-DRE-72689. Formation of a pool of free 40S subunits.
R-DRE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DRE-8849469. PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1.
R-DRE-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.
R-DRE-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-DRE-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-DRE-8856828. Clathrin-mediated endocytosis.
R-DRE-8863795. Downregulation of ERBB2 signaling.
R-DRE-8866652. Synthesis of active ubiquitin: roles of E1 and E2 enzymes.
R-DRE-901032. ER Quality Control Compartment (ERQC).
R-DRE-912631. Regulation of signaling by CBL.
R-DRE-917729. Endosomal Sorting Complex Required For Transport (ESCRT).
R-DRE-937042. IRAK2 mediated activation of TAK1 complex.
R-DRE-937072. TRAF6 mediated induction of TAK1 complex.
R-DRE-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
R-DRE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DRE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
R-DRE-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Submitted name:
Ubiquitin A-52 residue ribosomal protein fusion product 1Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:uba52Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 2

Organism-specific databases

ZFINiZDB-GENE-051023-7. uba52.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSDARG00000041435.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000060744.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 76Ubiquitin-likeInterPro annotationAdd BLAST76

Phylogenomic databases

eggNOGiKOG0003. Eukaryota.
COG1552. LUCA.
COG5272. LUCA.
GeneTreeiENSGT00860000133747.
HOGENOMiHOG000233942.
HOVERGENiHBG052927.
KOiK02927.
OMAiKTKCGHT.
OrthoDBiEOG091G178I.
TreeFamiTF352129.

Family and domain databases

InterProiIPR001975. Ribosomal_L40e.
IPR011332. Ribosomal_zn-bd.
IPR019956. Ubiquitin.
IPR029071. Ubiquitin-rel_dom.
IPR019954. Ubiquitin_CS.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF01020. Ribosomal_L40e. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
PRINTSiPR00348. UBIQUITIN.
SMARTiSM01377. Ribosomal_L40e. 1 hit.
SM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
SSF57829. SSF57829. 1 hit.
PROSITEiPS00299. UBIQUITIN_1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3B7P7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL
60 70 80 90 100
EDGRTLSDYN IQKESTLHLV LRLRGGIIEP SLRQLAQKYN CEKMICRKCY
110 120
ARLHPRAVNC RKKKCGHTNN LRPKKKLK
Length:128
Mass (Da):14,756
Last modified:November 22, 2005 - v1
Checksum:i7BDE802ABF51CA9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU693374 Genomic DNA. No translation available.
BC105746 mRNA. Translation: AAI05747.1.
BC107517 mRNA. Translation: AAI07518.1.
RefSeqiNP_001032190.1. NM_001037113.1.
UniGeneiDr.35198.

Genome annotation databases

EnsembliENSDART00000060745; ENSDARP00000060744; ENSDARG00000041435.
GeneIDi641289.
KEGGidre:641289.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU693374 Genomic DNA. No translation available.
BC105746 mRNA. Translation: AAI05747.1.
BC107517 mRNA. Translation: AAI07518.1.
RefSeqiNP_001032190.1. NM_001037113.1.
UniGeneiDr.35198.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000060744.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000060745; ENSDARP00000060744; ENSDARG00000041435.
GeneIDi641289.
KEGGidre:641289.

Organism-specific databases

CTDi7311.
ZFINiZDB-GENE-051023-7. uba52.

Phylogenomic databases

eggNOGiKOG0003. Eukaryota.
COG1552. LUCA.
COG5272. LUCA.
GeneTreeiENSGT00860000133747.
HOGENOMiHOG000233942.
HOVERGENiHBG052927.
KOiK02927.
OMAiKTKCGHT.
OrthoDBiEOG091G178I.
TreeFamiTF352129.

Enzyme and pathway databases

ReactomeiR-DRE-110312. Translesion synthesis by REV1.
R-DRE-110314. Recognition of DNA damage by PCNA-containing replication complex.
R-DRE-110320. Translesion Synthesis by POLH.
R-DRE-1169091. Activation of NF-kappaB in B cells.
R-DRE-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-DRE-1253288. Downregulation of ERBB4 signaling.
R-DRE-1295596. Spry regulation of FGF signaling.
R-DRE-1358803. Downregulation of ERBB2:ERBB3 signaling.
R-DRE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DRE-168638. NOD1/2 Signaling Pathway.
R-DRE-174048. APC/C:Cdc20 mediated degradation of Cyclin B.
R-DRE-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-DRE-174154. APC/C:Cdc20 mediated degradation of Securin.
R-DRE-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-DRE-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-DRE-179409. APC-Cdc20 mediated degradation of Nek2A.
R-DRE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DRE-182971. EGFR downregulation.
R-DRE-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-DRE-195253. Degradation of beta-catenin by the destruction complex.
R-DRE-201681. TCF dependent signaling in response to WNT.
R-DRE-202424. Downstream TCR signaling.
R-DRE-209543. p75NTR recruits signalling complexes.
R-DRE-209560. NF-kB is activated and signals survival.
R-DRE-2122948. Activated NOTCH1 Transmits Signal to the Nucleus.
R-DRE-2173788. Downregulation of TGF-beta receptor signaling.
R-DRE-2173791. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
R-DRE-2173795. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
R-DRE-2173796. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
R-DRE-2467813. Separation of Sister Chromatids.
R-DRE-2559580. Oxidative Stress Induced Senescence.
R-DRE-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-DRE-2559585. Oncogene Induced Senescence.
R-DRE-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-DRE-2871837. FCERI mediated NF-kB activation.
R-DRE-3134975. Regulation of innate immune responses to cytosolic DNA.
R-DRE-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-DRE-3769402. Deactivation of the beta-catenin transactivating complex.
R-DRE-382556. ABC-family proteins mediated transport.
R-DRE-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-DRE-446652. Interleukin-1 signaling.
R-DRE-450302. activated TAK1 mediates p38 MAPK activation.
R-DRE-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
R-DRE-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-DRE-4608870. Asymmetric localization of PCP proteins.
R-DRE-4641257. Degradation of AXIN.
R-DRE-4641258. Degradation of DVL.
R-DRE-4641263. Regulation of FZD by ubiquitination.
R-DRE-5205685. Pink/Parkin Mediated Mitophagy.
R-DRE-532668. N-glycan trimming in the ER and Calnexin/Calreticulin cycle.
R-DRE-5357905. Regulation of TNFR1 signaling.
R-DRE-5357956. TNFR1-induced NFkappaB signaling pathway.
R-DRE-5358346. Hedgehog ligand biogenesis.
R-DRE-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-DRE-5607764. CLEC7A (Dectin-1) signaling.
R-DRE-5610785. GLI3 is processed to GLI3R by the proteasome.
R-DRE-5632684. Hedgehog 'on' state.
R-DRE-5654726. Negative regulation of FGFR1 signaling.
R-DRE-5654727. Negative regulation of FGFR2 signaling.
R-DRE-5654732. Negative regulation of FGFR3 signaling.
R-DRE-5654733. Negative regulation of FGFR4 signaling.
R-DRE-5655862. Translesion synthesis by POLK.
R-DRE-5656121. Translesion synthesis by POLI.
R-DRE-5656169. Termination of translesion DNA synthesis.
R-DRE-5658442. Regulation of RAS by GAPs.
R-DRE-5668541. TNFR2 non-canonical NF-kB pathway.
R-DRE-5675221. Negative regulation of MAPK pathway.
R-DRE-5675482. Regulation of necroptotic cell death.
R-DRE-5676590. NIK-->noncanonical NF-kB signaling.
R-DRE-5684264. MAP3K8 (TPL2)-dependent MAPK1/3 activation.
R-DRE-5685942. HDR through Homologous Recombination (HRR).
R-DRE-5687128. MAPK6/MAPK4 signaling.
R-DRE-5689603. UCH proteinases.
R-DRE-5689877. Josephin domain DUBs.
R-DRE-5689880. Ub-specific processing proteases.
R-DRE-5689896. Ovarian tumor domain proteases.
R-DRE-5689901. Metalloprotease DUBs.
R-DRE-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-DRE-5696394. DNA Damage Recognition in GG-NER.
R-DRE-5696395. Formation of Incision Complex in GG-NER.
R-DRE-5696397. Gap-filling DNA repair synthesis and ligation in GG-NER.
R-DRE-5696400. Dual Incision in GG-NER.
R-DRE-6781823. Formation of TC-NER Pre-Incision Complex.
R-DRE-6782135. Dual incision in TC-NER.
R-DRE-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-DRE-6783310. Fanconi Anemia Pathway.
R-DRE-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-DRE-6804756. Regulation of TP53 Activity through Phosphorylation.
R-DRE-6804757. Regulation of TP53 Degradation.
R-DRE-6807004. Negative regulation of MET activity.
R-DRE-68827. CDT1 association with the CDC6:ORC:origin complex.
R-DRE-68949. Orc1 removal from chromatin.
R-DRE-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-DRE-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-DRE-69231. Cyclin D associated events in G1.
R-DRE-69298. Association of licensing factors with the pre-replicative complex.
R-DRE-69481. G2/M Checkpoints.
R-DRE-69541. Stabilization of p53.
R-DRE-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-DRE-72689. Formation of a pool of free 40S subunits.
R-DRE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DRE-8849469. PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1.
R-DRE-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.
R-DRE-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-DRE-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-DRE-8856828. Clathrin-mediated endocytosis.
R-DRE-8863795. Downregulation of ERBB2 signaling.
R-DRE-8866652. Synthesis of active ubiquitin: roles of E1 and E2 enzymes.
R-DRE-901032. ER Quality Control Compartment (ERQC).
R-DRE-912631. Regulation of signaling by CBL.
R-DRE-917729. Endosomal Sorting Complex Required For Transport (ESCRT).
R-DRE-937042. IRAK2 mediated activation of TAK1 complex.
R-DRE-937072. TRAF6 mediated induction of TAK1 complex.
R-DRE-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
R-DRE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DRE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
R-DRE-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Gene expression databases

BgeeiENSDARG00000041435.

Family and domain databases

InterProiIPR001975. Ribosomal_L40e.
IPR011332. Ribosomal_zn-bd.
IPR019956. Ubiquitin.
IPR029071. Ubiquitin-rel_dom.
IPR019954. Ubiquitin_CS.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF01020. Ribosomal_L40e. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
PRINTSiPR00348. UBIQUITIN.
SMARTiSM01377. Ribosomal_L40e. 1 hit.
SM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
SSF57829. SSF57829. 1 hit.
PROSITEiPS00299. UBIQUITIN_1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ3B7P7_DANRE
AccessioniPrimary (citable) accession number: Q3B7P7
Entry historyi
Integrated into UniProtKB/TrEMBL: November 22, 2005
Last sequence update: November 22, 2005
Last modified: November 30, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.