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Protein

LIM and SH3 domain protein 1

Gene

LASP1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding
Biological processIon transport, Transport
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM and SH3 domain protein 1
Short name:
LASP-1
Gene namesi
Name:LASP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002234741 – 260LIM and SH3 domain protein 1Add BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei42N6-acetyllysineBy similarity1
Modified residuei68PhosphothreonineBy similarity1
Modified residuei75N6-methyllysineBy similarity1
Modified residuei99PhosphoserineBy similarity1
Modified residuei104PhosphothreonineBy similarity1
Modified residuei112N6-succinyllysineBy similarity1
Modified residuei118PhosphoserineBy similarity1
Modified residuei134PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ3B7M5.
PeptideAtlasiQ3B7M5.
PRIDEiQ3B7M5.

Expressioni

Gene expression databases

BgeeiENSBTAG00000030587.

Interactioni

Subunit structurei

Interacts with F-actin (By similarity). Interacts with ANKRD54. Interacts with KBTBD10 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000040793.

Structurei

3D structure databases

ProteinModelPortaliQ3B7M5.
SMRiQ3B7M5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 56LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST52
Repeati61 – 95Nebulin 1Add BLAST35
Repeati97 – 131Nebulin 2Add BLAST35
Domaini201 – 260SH3PROSITE-ProRule annotationAdd BLAST60

Keywords - Domaini

LIM domain, Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG1702. Eukaryota.
ENOG4111GQ8. LUCA.
GeneTreeiENSGT00530000062924.
HOGENOMiHOG000006616.
HOVERGENiHBG054636.
InParanoidiQ3B7M5.
OMAiYGYKEPA.
OrthoDBiEOG091G0U2O.
TreeFamiTF319104.

Family and domain databases

CDDicd11934. SH3_Lasp1_C. 1 hit.
InterProiView protein in InterPro
IPR035630. Lasp1_SH3.
IPR000900. Nebulin_repeat.
IPR001452. SH3_domain.
IPR001781. Znf_LIM.
PfamiView protein in Pfam
PF00412. LIM. 1 hit.
PF00880. Nebulin. 2 hits.
PF14604. SH3_9. 1 hit.
PRINTSiPR00452. SH3DOMAIN.
SMARTiView protein in SMART
SM00132. LIM. 1 hit.
SM00227. NEBU. 2 hits.
SM00326. SH3. 1 hit.
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiView protein in PROSITE
PS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
PS51216. NEBULIN. 2 hits.
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3B7M5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPNCARCCK IVYPTEKVNC LDKFWHKACF HCETCKMTLN MKNYKGYEKK
60 70 80 90 100
PYCNAHYPKQ SFTMVADTPE NLRLKQQSEL QSQVRYKEEF EKNKGKGFSV
110 120 130 140 150
VADTPELQRI KKTQDQISNI KYHEEFEKSR MGPSGGEGLE CERRDPQESS
160 170 180 190 200
YRRPQEQQQP HHIPASTPVY QQPQQQPAAQ SYGGYKEPAA PASIQRSAPG
210 220 230 240 250
GGGKRYRAVY DYSAADEDEV SFQDGDTIVN VQQIDDGWMY GTVERTGDTG
260
MLPANYVEAI
Length:260
Mass (Da):29,677
Last modified:November 22, 2005 - v1
Checksum:i6572DF3BF3ADA430
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107542 mRNA. Translation: AAI07543.1.
RefSeqiNP_001030471.1. NM_001035394.1.
UniGeneiBt.7980.

Genome annotation databases

EnsembliENSBTAT00000043205; ENSBTAP00000040793; ENSBTAG00000030587.
GeneIDi532851.
KEGGibta:532851.

Similar proteinsi

Entry informationi

Entry nameiLASP1_BOVIN
AccessioniPrimary (citable) accession number: Q3B7M5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: November 22, 2005
Last modified: August 30, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome