Zinc finger protein 746 - Bos taurus (Bovine)

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Q3B7M4 (ZN746_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 60. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Zinc finger protein 746

Gene names

Name:

ZNF746

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	630 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death By similarity.
Subunit structure	Interacts (via C2H2-type zinc fingers) with PARK2 By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity. Note: Mainly localizes to the cytoplasm; probably translocates to the nucleus to repress selected genes By similarity.
Post-translational modification	Ubiquitinated by PARK2. 'Lys-48'-linked polyubiquitination by PARK2 leads to degradation by the proteasome and may play a key role in regulation of neuron death By similarity.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 4 C2H2-type zinc fingers. Contains 1 KRAB domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Domain	Coiled coil Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Repressor
PTM	Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of transcription, DNA-dependent Inferred from sequence or structural similarity. Source: UniProtKB neuron death Inferred from sequence or structural similarity. Source: UniProtKB regulation of cell death Inferred from sequence or structural similarity. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	transcription regulatory region DNA binding Inferred from sequence or structural similarity. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 630

630

Zinc finger protein 746

PRO_0000253727

Regions

Domain

96 – 167

KRAB

Zinc finger

454 – 476

C2H2-type 1; atypical

Zinc finger

496 – 518

C2H2-type 2

Zinc finger

524 – 546

C2H2-type 3

Zinc finger

552 – 575

C2H2-type 4; degenerate

Coiled coil

16 – 92

Potential

Compositional bias

2 – 7

Poly-Ala

Sequences

Sequence

Length

Mass (Da)

Tools

Q3B7M4 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: 170541E82C6E8057
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FASTA

630

67,972

        10         20         30         40         50         60 
MAEAAAAPIS PWTMAATIQA MERKIESQAA RLLSLEGRTG MAEKKLADCE KTAVEFGNQL 

        70         80         90        100        110        120 
EGKWAVLGTL LQEYGLLQRR LENVENLLRN RNFWILRLPP GSKGEAPKEW GKLDEWQKEL 

       130        140        150        160        170        180 
YKHVMRGNYE TLVSLDYAIS KPEVLSQIEQ GKEPCSWRRA GPKVPDVPVD PSPGSGPPVP 

       190        200        210        220        230        240 
APDLLMQIKQ EGELQLQEQQ ALGVEAWAAG QPDIGEEPWG LSQLDSGAGD VSTDAASGVH 

       250        260        270        280        290        300 
ANFSTTIPPT SWQADLPPHH PSSACSDGTL KLSTAASTEA DVKIVIKTEV QEEEVVATPV 

       310        320        330        340        350        360 
HPTDLEAHGT LFGPGQATRF FPSPVQEGAW ESQGSSFPSQ DPVLGLREPA RPERDLGDPT 

       370        380        390        400        410        420 
PTVPQDETSP GDWLFGGVRW GWNFRCKPPA GLNPRTGPEG LPFSSSDNGE AVLDPGQAPR 

       430        440        450        460        470        480 
PFNDPCKYPG RTKGFGHKPG LKKHPAAPPG GRPFTCATCG KSFQLQVSLS AHQRSCGGQP 

       490        500        510        520        530        540 
DGVPGAAGSA RDGSGLRCGE CGRCFTRPAH LIRHRMLHTG ERPFPCTECE KRFTERSKLI 

       550        560        570        580        590        600 
DHYRTHTGVR PFTCTVCGKS FIRKDHLRKH QRNHAAGAKP ARGQPLPPLP AVPPDPFKSP 

       610        620        630 
AAKGPLAPTD LVTDWTCGLS VLGPTDGGDL

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References

[1]	"The genome sequence of taurine cattle: a window to ruminant biology and evolution." The bovine genome sequencing and analysis consortium Science 324:522-528(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Hereford.
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFC03042442 Genomic DNA. No translation available. AAFC03042444 Genomic DNA. No translation available. AAFC03054460 Genomic DNA. No translation available. BC107543 mRNA. Translation: AAI07544.1.
IPI	IPI00706545.
RefSeq	NP_001030418.1. NM_001035341.1.
UniGene	Bt.40980.
3D structure databases
ProteinModelPortal	Q3B7M4.
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000001239.
Proteomic databases
PRIDE	Q3B7M4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	521998.
KEGG	bta:521998.
Organism-specific databases
CTD	155061.
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000013125.
HOVERGEN	HBG062119.
KO	K09228.
Family and domain databases
Gene3D	3.30.160.60. 4 hits.
InterPro	IPR022137. DUF3669_Znf. IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF12417. DUF3669. 1 hit. PF01352. KRAB. 1 hit. PF00096. zf-C2H2. 2 hits. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 4 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 3 hits. PS50157. ZINC_FINGER_C2H2_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	20873420.

Entry information

Entry name

ZN746_BOVIN

Accession

Primary (citable) accession number: Q3B7M4
Secondary accession number(s): E1BEU3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	November 22, 2005
Last modified:	April 3, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Other

Entry information

Relevant documents