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Protein

Folliculin

Gene

FLCN

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Folliculin
Gene namesi
Name:FLCN
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Mainly localized in the nucleus. Colocalizes with FNIP1 and FNIP2 in the cytoplasm (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 579579FolliculinPRO_0000223939Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei62 – 621PhosphoserineBy similarity
Modified residuei73 – 731PhosphoserineBy similarity
Modified residuei302 – 3021PhosphoserineBy similarity
Modified residuei571 – 5711PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3B7L5.
PRIDEiQ3B7L5.

Expressioni

Gene expression databases

BgeeiENSBTAG00000008010.

Interactioni

Subunit structurei

Interacts (via C-terminus) with FNIP1 and FNIP2 (via C-terminus). This mediates indirect interaction with the PRKAA1, PRKAB1 and PRKAG1 subunits of 5'-AMP-activated protein kinase (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010532.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili285 – 30925Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the folliculin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3715. Eukaryota.
ENOG410XQ9Y. LUCA.
GeneTreeiENSGT00390000009864.
HOGENOMiHOG000052507.
HOVERGENiHBG081531.
InParanoidiQ3B7L5.
KOiK09594.
OMAiVKLLKFW.
OrthoDBiEOG091G0C9Z.
TreeFamiTF315084.

Family and domain databases

InterProiIPR021713. Folliculin.
IPR032035. Folliculin_C.
[Graphical view]
PANTHERiPTHR31441. PTHR31441. 1 hit.
PfamiPF16692. Folliculin_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3B7L5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAIVALCHF CELHGPRTLF CTEVLHAPLP QGAGSGDGAG RGEPADEEEG
60 70 80 90 100
GIQMSSRIRA HSPAEGASAE SSSPGPKKSD MCEGCRSLAA GHPGYISHDK
110 120 130 140 150
ETSIKYVSHQ HPNHPQLFSI VRQACVRSLS CEVCPGREGP IFFGDEQHGF
160 170 180 190 200
VFSHTFFIKD SLARGFQRWY SIIAIMMDRI YLINSWPFLL GKIRGIIDEL
210 220 230 240 250
QGKALKVFEA EQFGCPQRAQ RMNTAFTPFL HQRNGNAARS LTSLTNDDSL
260 270 280 290 300
WACLHTSFAW LLKACGSRLT EKLLEGAPTE DTLVQMEQLA ELEEESESWD
310 320 330 340 350
NSEAEEEEKG PALPEGAEGR ELTKCPAESS LLSDCGAWQP RKLSVFKSLR
360 370 380 390 400
HMRQVLGAPS FRTLAWHVLM GNQVIWKSRD SDLVHSAFEV LRTMLPVGCV
410 420 430 440 450
RVIPYSSQYE EAYRCNFLGL SPHVQIPPHV LASEFAVVVE VHTATRSSLH
460 470 480 490 500
AVGCESEQPL SKYEFVVTSG SPVAADRVGP TILNKMEAAL TNQNLSVDVV
510 520 530 540 550
DQCLVCLKEE WMNKVKVLFK FTKVDSRPKE DTQKLLSILG ASEEDNVKLL
560 570
KFWMTGLSKT YKSHLMSTVR SPTALEPRN
Length:579
Mass (Da):64,204
Last modified:November 22, 2005 - v1
Checksum:i2629737C147DC497
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107555 mRNA. Translation: AAI07556.1.
RefSeqiNP_001030440.1. NM_001035363.1.
XP_015314213.1. XM_015458727.1.
UniGeneiBt.41523.

Genome annotation databases

EnsembliENSBTAT00000010532; ENSBTAP00000010532; ENSBTAG00000008010.
GeneIDi526652.
KEGGibta:526652.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107555 mRNA. Translation: AAI07556.1.
RefSeqiNP_001030440.1. NM_001035363.1.
XP_015314213.1. XM_015458727.1.
UniGeneiBt.41523.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010532.

Proteomic databases

PaxDbiQ3B7L5.
PRIDEiQ3B7L5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000010532; ENSBTAP00000010532; ENSBTAG00000008010.
GeneIDi526652.
KEGGibta:526652.

Organism-specific databases

CTDi201163.

Phylogenomic databases

eggNOGiKOG3715. Eukaryota.
ENOG410XQ9Y. LUCA.
GeneTreeiENSGT00390000009864.
HOGENOMiHOG000052507.
HOVERGENiHBG081531.
InParanoidiQ3B7L5.
KOiK09594.
OMAiVKLLKFW.
OrthoDBiEOG091G0C9Z.
TreeFamiTF315084.

Gene expression databases

BgeeiENSBTAG00000008010.

Family and domain databases

InterProiIPR021713. Folliculin.
IPR032035. Folliculin_C.
[Graphical view]
PANTHERiPTHR31441. PTHR31441. 1 hit.
PfamiPF16692. Folliculin_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFLCN_BOVIN
AccessioniPrimary (citable) accession number: Q3B7L5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: November 22, 2005
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.