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Protein

Glucose-fructose oxidoreductase domain-containing protein 2

Gene

GFOD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes matrix assembly.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-fructose oxidoreductase domain-containing protein 2 (EC:1.-.-.-)
Gene namesi
Name:GFOD2
ORF Names:UNQ9430/PRO34691
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:28159. GFOD2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000141098.
PharmGKBiPA144596430.

Polymorphism and mutation databases

BioMutaiGFOD2.
DMDMi121942382.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000028297226 – 385Glucose-fructose oxidoreductase domain-containing protein 2Add BLAST360

Proteomic databases

EPDiQ3B7J2.
MaxQBiQ3B7J2.
PaxDbiQ3B7J2.
PeptideAtlasiQ3B7J2.
PRIDEiQ3B7J2.
TopDownProteomicsiQ3B7J2-1. [Q3B7J2-1]

PTM databases

iPTMnetiQ3B7J2.
PhosphoSitePlusiQ3B7J2.

Expressioni

Gene expression databases

BgeeiENSG00000141098.
CleanExiHS_GFOD2.
ExpressionAtlasiQ3B7J2. baseline and differential.
GenevisibleiQ3B7J2. HS.

Organism-specific databases

HPAiHPA040939.
HPA041112.

Interactioni

Protein-protein interaction databases

BioGridi123537. 3 interactors.
IntActiQ3B7J2. 1 interactor.
STRINGi9606.ENSP00000268797.

Structurei

3D structure databases

ProteinModelPortaliQ3B7J2.
SMRiQ3B7J2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Gfo/Idh/MocA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2742. Eukaryota.
COG0673. LUCA.
GeneTreeiENSGT00390000001507.
HOGENOMiHOG000010274.
HOVERGENiHBG054911.
InParanoidiQ3B7J2.
OMAiRRTWDHT.
OrthoDBiEOG091G0FOZ.
PhylomeDBiQ3B7J2.
TreeFamiTF323246.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3B7J2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKMLPGVGVF GTGSSARVLV PLLRAEGFTV EALWGKTEEE AKQLAEEMNI
60 70 80 90 100
AFYTSRTDDI LLHQDVDLVC ISIPPPLTRQ ISVKALGIGK NVVCEKAATS
110 120 130 140 150
VDAFRMVTAS RYYPQLMSLV GNVLRFLPAF VRMKQLISEH YVGAVMICDA
160 170 180 190 200
RIYSGSLLSP SYGWICDELM GGGGLHTMGT YIVDLLTHLT GRRAEKVHGL
210 220 230 240 250
LKTFVRQNAA IRGIRHVTSD DFCFFQMLMG GGVCSTVTLN FNMPGAFVHE
260 270 280 290 300
VMVVGSAGRL VARGADLYGQ KNSATQEELL LRDSLAVGAG LPEQGPQDVP
310 320 330 340 350
LLYLKGMVYM VQALRQSFQG QGDRRTWDRT PVSMAASFED GLYMQSVVDA
360 370 380
IKRSSRSGEW EAVEVLTEEP DTNQNLCEAL QRNNL
Length:385
Mass (Da):42,255
Last modified:November 22, 2005 - v1
Checksum:iD516EE4CC5CF5667
GO
Isoform 2 (identifier: Q3B7J2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-105: Missing.

Show »
Length:280
Mass (Da):30,912
Checksum:iBDB78411672FE58F
GO
Isoform 3 (identifier: Q3B7J2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-112: GIGKNVVCEKAATSVDAFRMVTASRY → GTPGRPQQGQIMSLPLGSPLRVTPLL
     113-385: Missing.

Note: No experimental confirmation available.
Show »
Length:112
Mass (Da):12,110
Checksum:iC6E746EFD015716A
GO

Sequence cautioni

The sequence AAQ88536 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8G → D in BAB85066 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054433231G → V.Corresponds to variant rs11539687dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0242621 – 105Missing in isoform 2. 1 PublicationAdd BLAST105
Alternative sequenceiVSP_05518587 – 112GIGKN…TASRY → GTPGRPQQGQIMSLPLGSPL RVTPLL in isoform 3. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_055186113 – 385Missing in isoform 3. 1 PublicationAdd BLAST273

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358169 mRNA. Translation: AAQ88536.1. Different initiation.
AK074382 mRNA. Translation: BAB85066.1.
AK307280 mRNA. No translation available.
AC010530 Genomic DNA. No translation available.
BC000757 mRNA. Translation: AAH00757.1.
BC002943 mRNA. Translation: AAH02943.2.
BC107585 mRNA. Translation: AAI07586.1.
AL832904 mRNA. Translation: CAH10637.1.
CCDSiCCDS10845.1. [Q3B7J2-1]
CCDS59268.1. [Q3B7J2-3]
RefSeqiNP_001230579.1. NM_001243650.1. [Q3B7J2-3]
NP_110446.3. NM_030819.3. [Q3B7J2-1]
XP_006721351.1. XM_006721288.3. [Q3B7J2-2]
XP_016879227.1. XM_017023738.1. [Q3B7J2-1]
UniGeneiHs.307084.

Genome annotation databases

EnsembliENST00000268797; ENSP00000268797; ENSG00000141098. [Q3B7J2-1]
ENST00000602279; ENSP00000478260; ENSG00000141098. [Q3B7J2-3]
ENST00000602496; ENSP00000473641; ENSG00000141098. [Q3B7J2-3]
GeneIDi81577.
KEGGihsa:81577.
UCSCiuc002eub.4. human. [Q3B7J2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358169 mRNA. Translation: AAQ88536.1. Different initiation.
AK074382 mRNA. Translation: BAB85066.1.
AK307280 mRNA. No translation available.
AC010530 Genomic DNA. No translation available.
BC000757 mRNA. Translation: AAH00757.1.
BC002943 mRNA. Translation: AAH02943.2.
BC107585 mRNA. Translation: AAI07586.1.
AL832904 mRNA. Translation: CAH10637.1.
CCDSiCCDS10845.1. [Q3B7J2-1]
CCDS59268.1. [Q3B7J2-3]
RefSeqiNP_001230579.1. NM_001243650.1. [Q3B7J2-3]
NP_110446.3. NM_030819.3. [Q3B7J2-1]
XP_006721351.1. XM_006721288.3. [Q3B7J2-2]
XP_016879227.1. XM_017023738.1. [Q3B7J2-1]
UniGeneiHs.307084.

3D structure databases

ProteinModelPortaliQ3B7J2.
SMRiQ3B7J2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123537. 3 interactors.
IntActiQ3B7J2. 1 interactor.
STRINGi9606.ENSP00000268797.

PTM databases

iPTMnetiQ3B7J2.
PhosphoSitePlusiQ3B7J2.

Polymorphism and mutation databases

BioMutaiGFOD2.
DMDMi121942382.

Proteomic databases

EPDiQ3B7J2.
MaxQBiQ3B7J2.
PaxDbiQ3B7J2.
PeptideAtlasiQ3B7J2.
PRIDEiQ3B7J2.
TopDownProteomicsiQ3B7J2-1. [Q3B7J2-1]

Protocols and materials databases

DNASUi81577.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268797; ENSP00000268797; ENSG00000141098. [Q3B7J2-1]
ENST00000602279; ENSP00000478260; ENSG00000141098. [Q3B7J2-3]
ENST00000602496; ENSP00000473641; ENSG00000141098. [Q3B7J2-3]
GeneIDi81577.
KEGGihsa:81577.
UCSCiuc002eub.4. human. [Q3B7J2-1]

Organism-specific databases

CTDi81577.
GeneCardsiGFOD2.
HGNCiHGNC:28159. GFOD2.
HPAiHPA040939.
HPA041112.
neXtProtiNX_Q3B7J2.
OpenTargetsiENSG00000141098.
PharmGKBiPA144596430.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2742. Eukaryota.
COG0673. LUCA.
GeneTreeiENSGT00390000001507.
HOGENOMiHOG000010274.
HOVERGENiHBG054911.
InParanoidiQ3B7J2.
OMAiRRTWDHT.
OrthoDBiEOG091G0FOZ.
PhylomeDBiQ3B7J2.
TreeFamiTF323246.

Miscellaneous databases

GenomeRNAii81577.
PROiQ3B7J2.

Gene expression databases

BgeeiENSG00000141098.
CleanExiHS_GFOD2.
ExpressionAtlasiQ3B7J2. baseline and differential.
GenevisibleiQ3B7J2. HS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGFOD2_HUMAN
AccessioniPrimary (citable) accession number: Q3B7J2
Secondary accession number(s): Q69YL9
, Q6UXX6, Q7L648, Q8TE86, Q9BQ07, R4GNG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: November 22, 2005
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.