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Protein

Ubiquitin-conjugating enzyme E2 Z

Gene

Ube2z

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins. Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation (By similarity).PROSITE-ProRule annotation

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

Pathway:iprotein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei190 – 1901Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Apoptosis, Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 Z (EC:6.3.2.19)
Alternative name(s):
Uba6-specific E2 conjugating enzyme 1
Short name:
Use1
Ubiquitin carrier protein Z
Ubiquitin-protein ligase Z
Gene namesi
Name:Ube2z
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1308347. Ube2z.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356Ubiquitin-conjugating enzyme E2 ZPRO_0000280517Add
BLAST

Proteomic databases

PaxDbiQ3B7D1.
PRIDEiQ3B7D1.

PTM databases

PhosphoSiteiQ3B7D1.

Expressioni

Gene expression databases

GenevisibleiQ3B7D1. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052365.

Structurei

3D structure databases

ProteinModelPortaliQ3B7D1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5078.
GeneTreeiENSGT00730000110680.
HOGENOMiHOG000233451.
HOVERGENiHBG083204.
InParanoidiQ3B7D1.
KOiK10585.
OMAiHQQDSAE.
OrthoDBiEOG7MSMP5.
PhylomeDBiQ3B7D1.
TreeFamiTF354204.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3B7D1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESPTEEAA TATAGAGAAG PGASGVAGVV GVSGSGGGFG PPFLPDVWAA
60 70 80 90 100
AAAAGGAGGP GSGLAPLPGL PPSAAAHGAA LLSHWDPTLS SDWDGERTAP
110 120 130 140 150
QCLLRIKRDI MSIYKEPPPG MFVVPDTVDM TKIHALITGP FDTPYEGGFF
160 170 180 190 200
LFVFRCPPDY PIHPPRVKLM TTGNNTVRFN PNFYRNGKVC LSILGTWTGP
210 220 230 240 250
AWSPAQSISS VLISIQSLMT ENPYHNEPGF EQERHPGDSK NYNECIRHET
260 270 280 290 300
IRVAVCDMME GKCPCPEPLR GVMEKSFLEY YDFYEVACKD RLHLQGQTMQ
310 320 330 340 350
DPFGEKRGHF DYQSLLMRLG LIRQKVLERL HNENAEMDSD SSSSGTETDL

HGSLRV
Length:356
Mass (Da):38,352
Last modified:March 20, 2007 - v2
Checksum:i3C77B50527A30676
GO

Sequence cautioni

The sequence AAI07664.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107663 mRNA. Translation: AAI07664.1. Different initiation.
RefSeqiNP_001032732.2. NM_001037643.2.
UniGeneiRn.16992.

Genome annotation databases

EnsembliENSRNOT00000055500; ENSRNOP00000052365; ENSRNOG00000006868.
GeneIDi303478.
KEGGirno:303478.
UCSCiRGD:1308347. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107663 mRNA. Translation: AAI07664.1. Different initiation.
RefSeqiNP_001032732.2. NM_001037643.2.
UniGeneiRn.16992.

3D structure databases

ProteinModelPortaliQ3B7D1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052365.

PTM databases

PhosphoSiteiQ3B7D1.

Proteomic databases

PaxDbiQ3B7D1.
PRIDEiQ3B7D1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000055500; ENSRNOP00000052365; ENSRNOG00000006868.
GeneIDi303478.
KEGGirno:303478.
UCSCiRGD:1308347. rat.

Organism-specific databases

CTDi65264.
RGDi1308347. Ube2z.

Phylogenomic databases

eggNOGiCOG5078.
GeneTreeiENSGT00730000110680.
HOGENOMiHOG000233451.
HOVERGENiHBG083204.
InParanoidiQ3B7D1.
KOiK10585.
OMAiHQQDSAE.
OrthoDBiEOG7MSMP5.
PhylomeDBiQ3B7D1.
TreeFamiTF354204.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

NextBioi651406.
PROiQ3B7D1.

Gene expression databases

GenevisibleiQ3B7D1. RN.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiUBE2Z_RAT
AccessioniPrimary (citable) accession number: Q3B7D1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: July 22, 2015
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.