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Q3B7D1

- UBE2Z_RAT

UniProt

Q3B7D1 - UBE2Z_RAT

Protein

Ubiquitin-conjugating enzyme E2 Z

Gene

Ube2z

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 2 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the covalent attachment of ubiquitin to other proteins. Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation By similarity.PROSITE-ProRule annotation

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei190 – 1901Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Apoptosis, Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-conjugating enzyme E2 Z (EC:6.3.2.19)
    Alternative name(s):
    Uba6-specific E2 conjugating enzyme 1
    Short name:
    Use1
    Ubiquitin carrier protein Z
    Ubiquitin-protein ligase Z
    Gene namesi
    Name:Ube2z
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi1308347. Ube2z.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 356356Ubiquitin-conjugating enzyme E2 ZPRO_0000280517Add
    BLAST

    Proteomic databases

    PaxDbiQ3B7D1.
    PRIDEiQ3B7D1.

    PTM databases

    PhosphoSiteiQ3B7D1.

    Expressioni

    Gene expression databases

    GenevestigatoriQ3B7D1.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000052365.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3B7D1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5078.
    GeneTreeiENSGT00730000110680.
    HOGENOMiHOG000233451.
    HOVERGENiHBG083204.
    InParanoidiQ3B7D1.
    KOiK10585.
    OMAiAVMANMS.
    OrthoDBiEOG7MSMP5.
    PhylomeDBiQ3B7D1.
    TreeFamiTF354204.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3B7D1-1 [UniParc]FASTAAdd to Basket

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    MAESPTEEAA TATAGAGAAG PGASGVAGVV GVSGSGGGFG PPFLPDVWAA    50
    AAAAGGAGGP GSGLAPLPGL PPSAAAHGAA LLSHWDPTLS SDWDGERTAP 100
    QCLLRIKRDI MSIYKEPPPG MFVVPDTVDM TKIHALITGP FDTPYEGGFF 150
    LFVFRCPPDY PIHPPRVKLM TTGNNTVRFN PNFYRNGKVC LSILGTWTGP 200
    AWSPAQSISS VLISIQSLMT ENPYHNEPGF EQERHPGDSK NYNECIRHET 250
    IRVAVCDMME GKCPCPEPLR GVMEKSFLEY YDFYEVACKD RLHLQGQTMQ 300
    DPFGEKRGHF DYQSLLMRLG LIRQKVLERL HNENAEMDSD SSSSGTETDL 350
    HGSLRV 356
    Length:356
    Mass (Da):38,352
    Last modified:March 20, 2007 - v2
    Checksum:i3C77B50527A30676
    GO

    Sequence cautioni

    The sequence AAI07664.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC107663 mRNA. Translation: AAI07664.1. Different initiation.
    RefSeqiNP_001032732.2. NM_001037643.2.
    UniGeneiRn.16992.

    Genome annotation databases

    EnsembliENSRNOT00000055500; ENSRNOP00000052365; ENSRNOG00000006868.
    GeneIDi303478.
    KEGGirno:303478.
    UCSCiRGD:1308347. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC107663 mRNA. Translation: AAI07664.1 . Different initiation.
    RefSeqi NP_001032732.2. NM_001037643.2.
    UniGenei Rn.16992.

    3D structure databases

    ProteinModelPortali Q3B7D1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000052365.

    PTM databases

    PhosphoSitei Q3B7D1.

    Proteomic databases

    PaxDbi Q3B7D1.
    PRIDEi Q3B7D1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000055500 ; ENSRNOP00000052365 ; ENSRNOG00000006868 .
    GeneIDi 303478.
    KEGGi rno:303478.
    UCSCi RGD:1308347. rat.

    Organism-specific databases

    CTDi 65264.
    RGDi 1308347. Ube2z.

    Phylogenomic databases

    eggNOGi COG5078.
    GeneTreei ENSGT00730000110680.
    HOGENOMi HOG000233451.
    HOVERGENi HBG083204.
    InParanoidi Q3B7D1.
    KOi K10585.
    OMAi AVMANMS.
    OrthoDBi EOG7MSMP5.
    PhylomeDBi Q3B7D1.
    TreeFami TF354204.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    NextBioi 651406.
    PROi Q3B7D1.

    Gene expression databases

    Genevestigatori Q3B7D1.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.

    Entry informationi

    Entry nameiUBE2Z_RAT
    AccessioniPrimary (citable) accession number: Q3B7D1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 72 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3