Q3B7D1 (UBE2Z_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin-conjugating enzyme E2 Z
EC=6.3.2.19

Alternative name(s):
Uba6-specific E2 conjugating enzyme 1
Short name=Use1
Ubiquitin carrier protein Z
Ubiquitin-protein ligase Z

Gene names

Name:

Ube2z

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	356 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the covalent attachment of ubiquitin to other proteins. Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation By similarity.
Catalytic activity	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
Pathway	Protein modification; protein ubiquitination.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the ubiquitin-conjugating enzyme family.
Sequence caution	The sequence AAI07664.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Apoptosis Ubl conjugation pathway
Cellular component	Cytoplasm Nucleus
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin-protein ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 356	356	Ubiquitin-conjugating enzyme E2 Z		PRO_0000280517
Sites
	Active site	190	1	Glycyl thioester intermediate By similarity
Amino acid modifications
	Modified residue	339	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3B7D1 [UniParc]. Last modified March 20, 2007. Version 2. Checksum: 3C77B50527A30676	FASTA	356	38,352
	10 20 30 40 50 60 MAESPTEEAA TATAGAGAAG PGASGVAGVV GVSGSGGGFG PPFLPDVWAA AAAAGGAGGP 70 80 90 100 110 120 GSGLAPLPGL PPSAAAHGAA LLSHWDPTLS SDWDGERTAP QCLLRIKRDI MSIYKEPPPG 130 140 150 160 170 180 MFVVPDTVDM TKIHALITGP FDTPYEGGFF LFVFRCPPDY PIHPPRVKLM TTGNNTVRFN 190 200 210 220 230 240 PNFYRNGKVC LSILGTWTGP AWSPAQSISS VLISIQSLMT ENPYHNEPGF EQERHPGDSK 250 260 270 280 290 300 NYNECIRHET IRVAVCDMME GKCPCPEPLR GVMEKSFLEY YDFYEVACKD RLHLQGQTMQ 310 320 330 340 350 DPFGEKRGHF DYQSLLMRLG LIRQKVLERL HNENAEMDSD SSSSGTETDL HGSLRV

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC107663 mRNA. Translation: AAI07664.1. Different initiation.
IPI	IPI00779658.
RefSeq	NP_001032732.2. NM_001037643.2.
UniGene	Rn.16992.
3D structure databases
HSSP	HSSP built from PDB template 2C2V based on UniProtKB P61088.
ProteinModelPortal	Q3B7D1.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000052365.
PTM databases
PhosphoSite	Q3B7D1.
Proteomic databases
PaxDb	Q3B7D1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000055500; ENSRNOP00000052365; ENSRNOG00000006868.
GeneID	303478.
KEGG	rno:303478.
UCSC	RGD:1308347. rat.
Organism-specific databases
CTD	65264.
RGD	1308347. Ube2z.
Phylogenomic databases
eggNOG	COG5078.
GeneTree	ENSGT00680000099547.
HOGENOM	HOG000233451.
HOVERGEN	HBG083204.
InParanoid	Q3B7D1.
KO	K10585.
OMA	AVMANMS.
OrthoDB	EOG4ZCT54.
Enzyme and pathway databases
UniPathway	UPA00143.
Gene expression databases
Genevestigator	Q3B7D1.
Family and domain databases
Gene3D	3.10.110.10. 1 hit.
InterPro	IPR000608. UBQ-conjugat_E2. IPR016135. UBQ-conjugating_enzyme/RWD. [Graphical view]
Pfam	PF00179. UQ_con. 1 hit. [Graphical view]
SUPFAM	SSF54495. UBQ-conjugat/RWD-like. 1 hit.
PROSITE	PS00183. UBIQUITIN_CONJUGAT_1. False negative. PS50127. UBIQUITIN_CONJUGAT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	651406.

Entry information

Entry name

UBE2Z_RAT

Accession

Primary (citable) accession number: Q3B7D1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	March 20, 2007
Last modified:	April 3, 2013
This is version 63 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program