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Q3B7D1

- UBE2Z_RAT

UniProt

Q3B7D1 - UBE2Z_RAT

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Protein

Ubiquitin-conjugating enzyme E2 Z

Gene

Ube2z

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins. Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation (By similarity).PROSITE-ProRule annotation

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei190 – 1901Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. acid-amino acid ligase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Apoptosis, Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 Z (EC:6.3.2.19)
Alternative name(s):
Uba6-specific E2 conjugating enzyme 1
Short name:
Use1
Ubiquitin carrier protein Z
Ubiquitin-protein ligase Z
Gene namesi
Name:Ube2z
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi1308347. Ube2z.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356Ubiquitin-conjugating enzyme E2 ZPRO_0000280517Add
BLAST

Proteomic databases

PaxDbiQ3B7D1.
PRIDEiQ3B7D1.

PTM databases

PhosphoSiteiQ3B7D1.

Expressioni

Gene expression databases

GenevestigatoriQ3B7D1.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052365.

Structurei

3D structure databases

ProteinModelPortaliQ3B7D1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5078.
GeneTreeiENSGT00730000110680.
HOGENOMiHOG000233451.
HOVERGENiHBG083204.
InParanoidiQ3B7D1.
KOiK10585.
OMAiAVMANMS.
OrthoDBiEOG7MSMP5.
PhylomeDBiQ3B7D1.
TreeFamiTF354204.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3B7D1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAESPTEEAA TATAGAGAAG PGASGVAGVV GVSGSGGGFG PPFLPDVWAA
60 70 80 90 100
AAAAGGAGGP GSGLAPLPGL PPSAAAHGAA LLSHWDPTLS SDWDGERTAP
110 120 130 140 150
QCLLRIKRDI MSIYKEPPPG MFVVPDTVDM TKIHALITGP FDTPYEGGFF
160 170 180 190 200
LFVFRCPPDY PIHPPRVKLM TTGNNTVRFN PNFYRNGKVC LSILGTWTGP
210 220 230 240 250
AWSPAQSISS VLISIQSLMT ENPYHNEPGF EQERHPGDSK NYNECIRHET
260 270 280 290 300
IRVAVCDMME GKCPCPEPLR GVMEKSFLEY YDFYEVACKD RLHLQGQTMQ
310 320 330 340 350
DPFGEKRGHF DYQSLLMRLG LIRQKVLERL HNENAEMDSD SSSSGTETDL

HGSLRV
Length:356
Mass (Da):38,352
Last modified:March 20, 2007 - v2
Checksum:i3C77B50527A30676
GO

Sequence cautioni

The sequence AAI07664.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC107663 mRNA. Translation: AAI07664.1. Different initiation.
RefSeqiNP_001032732.2. NM_001037643.2.
UniGeneiRn.16992.

Genome annotation databases

EnsembliENSRNOT00000055500; ENSRNOP00000052365; ENSRNOG00000006868.
GeneIDi303478.
KEGGirno:303478.
UCSCiRGD:1308347. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC107663 mRNA. Translation: AAI07664.1 . Different initiation.
RefSeqi NP_001032732.2. NM_001037643.2.
UniGenei Rn.16992.

3D structure databases

ProteinModelPortali Q3B7D1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000052365.

PTM databases

PhosphoSitei Q3B7D1.

Proteomic databases

PaxDbi Q3B7D1.
PRIDEi Q3B7D1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000055500 ; ENSRNOP00000052365 ; ENSRNOG00000006868 .
GeneIDi 303478.
KEGGi rno:303478.
UCSCi RGD:1308347. rat.

Organism-specific databases

CTDi 65264.
RGDi 1308347. Ube2z.

Phylogenomic databases

eggNOGi COG5078.
GeneTreei ENSGT00730000110680.
HOGENOMi HOG000233451.
HOVERGENi HBG083204.
InParanoidi Q3B7D1.
KOi K10585.
OMAi AVMANMS.
OrthoDBi EOG7MSMP5.
PhylomeDBi Q3B7D1.
TreeFami TF354204.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

NextBioi 651406.
PROi Q3B7D1.

Gene expression databases

Genevestigatori Q3B7D1.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiUBE2Z_RAT
AccessioniPrimary (citable) accession number: Q3B7D1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: October 29, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3