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Protein

Ubiquitin-conjugating enzyme E2 Z

Gene

Ube2z

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins. Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation.PROSITE-ProRule annotation

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei190Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processApoptosis, Ubl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 Z (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme Z
Uba6-specific E2 conjugating enzyme 1
Short name:
Use1
Ubiquitin carrier protein Z
Ubiquitin-protein ligase Z
Gene namesi
Name:Ube2z
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1308347 Ube2z

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002805171 – 356Ubiquitin-conjugating enzyme E2 ZAdd BLAST356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei339PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3B7D1
PRIDEiQ3B7D1

PTM databases

iPTMnetiQ3B7D1
PhosphoSitePlusiQ3B7D1

Expressioni

Gene expression databases

BgeeiENSRNOG00000006868
GenevisibleiQ3B7D1 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052365

Structurei

3D structure databases

ProteinModelPortaliQ3B7D1
SMRiQ3B7D1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410ITJE Eukaryota
COG5078 LUCA
GeneTreeiENSGT00730000110680
HOGENOMiHOG000233451
HOVERGENiHBG083204
InParanoidiQ3B7D1
KOiK10585
OMAiYYDFYEG
OrthoDBiEOG091G0K0Y
PhylomeDBiQ3B7D1
TreeFamiTF354204

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q3B7D1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESPTEEAA TATAGAGAAG PGASGVAGVV GVSGSGGGFG PPFLPDVWAA
60 70 80 90 100
AAAAGGAGGP GSGLAPLPGL PPSAAAHGAA LLSHWDPTLS SDWDGERTAP
110 120 130 140 150
QCLLRIKRDI MSIYKEPPPG MFVVPDTVDM TKIHALITGP FDTPYEGGFF
160 170 180 190 200
LFVFRCPPDY PIHPPRVKLM TTGNNTVRFN PNFYRNGKVC LSILGTWTGP
210 220 230 240 250
AWSPAQSISS VLISIQSLMT ENPYHNEPGF EQERHPGDSK NYNECIRHET
260 270 280 290 300
IRVAVCDMME GKCPCPEPLR GVMEKSFLEY YDFYEVACKD RLHLQGQTMQ
310 320 330 340 350
DPFGEKRGHF DYQSLLMRLG LIRQKVLERL HNENAEMDSD SSSSGTETDL

HGSLRV
Length:356
Mass (Da):38,352
Last modified:March 20, 2007 - v2
Checksum:i3C77B50527A30676
GO

Sequence cautioni

The sequence AAI07664 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107663 mRNA Translation: AAI07664.1 Different initiation.
RefSeqiNP_001032732.2, NM_001037643.2
UniGeneiRn.16992

Genome annotation databases

EnsembliENSRNOT00000055500; ENSRNOP00000052365; ENSRNOG00000006868
GeneIDi303478
KEGGirno:303478
UCSCiRGD:1308347 rat

Similar proteinsi

Entry informationi

Entry nameiUBE2Z_RAT
AccessioniPrimary (citable) accession number: Q3B7D1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: April 25, 2018
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health