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Q3B7D0

- HEM6_RAT

UniProt

Q3B7D0 - HEM6_RAT

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Protein

Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

Gene

Cpox

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX (By similarity).By similarity

Catalytic activityi

Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O.1 Publication

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei233 – 2331SubstrateBy similarity
Active sitei247 – 2471Proton donorBy similarity
Sitei316 – 3161Important for dimerizationBy similarity

GO - Molecular functioni

  1. coproporphyrinogen oxidase activity Source: RGD
  2. identical protein binding Source: RGD
  3. protein homodimerization activity Source: UniProtKB
  4. structural constituent of eye lens Source: Ensembl

GO - Biological processi

  1. heme biosynthetic process Source: RGD
  2. protoporphyrinogen IX biosynthetic process Source: RGD
  3. response to arsenic-containing substance Source: RGD
  4. response to inorganic substance Source: RGD
  5. response to insecticide Source: RGD
  6. response to iron ion Source: RGD
  7. response to lead ion Source: RGD
  8. response to methylmercury Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Enzyme and pathway databases

ReactomeiREACT_263802. Heme biosynthesis.
UniPathwayiUPA00251; UER00322.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial (EC:1.3.3.3)
Short name:
COX
Short name:
Coprogen oxidase
Short name:
Coproporphyrinogenase
Gene namesi
Name:CpoxImported
Synonyms:Cpo
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 11

Organism-specific databases

RGDi1311817. Cpox.

Subcellular locationi

Mitochondrion intermembrane space 1 Publication

GO - Cellular componenti

  1. mitochondrial inner membrane Source: RGD
  2. mitochondrial intermembrane space Source: RGD
  3. mitochondrion Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 9898MitochondrionBy similarityAdd
BLAST
Chaini99 – 443345Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrialPRO_0000293624Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei393 – 3931N6-acetyllysine; alternateBy similarity
Modified residuei393 – 3931N6-succinyllysine; alternateBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ3B7D0.
PRIDEiQ3B7D0.

PTM databases

PhosphoSiteiQ3B7D0.

Expressioni

Gene expression databases

GenevestigatoriQ3B7D0.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002257.

Structurei

3D structure databases

ProteinModelPortaliQ3B7D0.
SMRiQ3B7D0. Positions 110-442.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni182 – 19110Important for dimerizationBy similarity
Regioni249 – 2513Substrate bindingBy similarity
Regioni381 – 41737Important for dimerizationBy similarityAdd
BLAST
Regioni400 – 4056Substrate bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0408.
GeneTreeiENSGT00390000017311.
HOGENOMiHOG000262768.
HOVERGENiHBG051897.
InParanoidiQ3B7D0.
KOiK00228.
OMAiRYFETAN.
OrthoDBiEOG7BZVSG.
PhylomeDBiQ3B7D0.
TreeFamiTF300703.

Family and domain databases

Gene3Di3.40.1500.10. 1 hit.
InterProiIPR001260. Coprogen_oxidase_aer.
IPR018375. Coprogen_oxidase_CS.
[Graphical view]
PANTHERiPTHR10755. PTHR10755. 1 hit.
PfamiPF01218. Coprogen_oxidas. 1 hit.
[Graphical view]
PRINTSiPR00073. COPRGNOXDASE.
SUPFAMiSSF102886. SSF102886. 1 hit.
PROSITEiPS01021. COPROGEN_OXIDASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3B7D0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALRLGQLGS GPWWRAVRGD YAQLRAPSPR SASACVCRLP GTAGTQPRRG
60 70 80 90 100
LGHGSSAGGG SRLGTGLAAA LAGMAGLAAA VLGHVQRAEM VPKSSGARSP
110 120 130 140 150
SPGRLEEDGD ELARRCSTFM SSPVTELREL GRRPDDMKTK MELMIMETQA
160 170 180 190 200
QVCRALAQVD GVADFSVDRW ERKEGGGGIT CVLQDGRVFE KAGVNISVVH
210 220 230 240 250
GNLSEEAANQ MRSRGKALKK KDGKLPFTAM GISSVIHPKN PYAPTMHFNY
260 270 280 290 300
RYFEVEEADG KMHWWFGGGC DLTPTYLNRE DAVHFHRTLK EACDQHGPDI
310 320 330 340 350
YPKFKKWCDD YFFIAHRGER RGIGGIFFDD LDSPSKEEAF RFVKTCAEAV
360 370 380 390 400
VPSYVPIVKK HCDDSYTPQD KLWQQLRRGR YVEFNLVYDR GTKFGLFTPG
410 420 430 440
SRIESILMSL PLTARWEYMH SPPENSKEAE ILEVLRHPKD WVH
Length:443
Mass (Da):49,278
Last modified:November 22, 2005 - v1
Checksum:iC599A521060628A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107664 mRNA. Translation: AAI07665.1.
RefSeqiNP_001032172.1. NM_001037095.1.
UniGeneiRn.19581.

Genome annotation databases

EnsembliENSRNOT00000002257; ENSRNOP00000002257; ENSRNOG00000001654.
GeneIDi304024.
KEGGirno:304024.
UCSCiRGD:1311817. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107664 mRNA. Translation: AAI07665.1 .
RefSeqi NP_001032172.1. NM_001037095.1.
UniGenei Rn.19581.

3D structure databases

ProteinModelPortali Q3B7D0.
SMRi Q3B7D0. Positions 110-442.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000002257.

PTM databases

PhosphoSitei Q3B7D0.

Proteomic databases

PaxDbi Q3B7D0.
PRIDEi Q3B7D0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000002257 ; ENSRNOP00000002257 ; ENSRNOG00000001654 .
GeneIDi 304024.
KEGGi rno:304024.
UCSCi RGD:1311817. rat.

Organism-specific databases

CTDi 1371.
RGDi 1311817. Cpox.

Phylogenomic databases

eggNOGi COG0408.
GeneTreei ENSGT00390000017311.
HOGENOMi HOG000262768.
HOVERGENi HBG051897.
InParanoidi Q3B7D0.
KOi K00228.
OMAi RYFETAN.
OrthoDBi EOG7BZVSG.
PhylomeDBi Q3B7D0.
TreeFami TF300703.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00322 .
Reactomei REACT_263802. Heme biosynthesis.

Miscellaneous databases

NextBioi 652479.
PROi Q3B7D0.

Gene expression databases

Genevestigatori Q3B7D0.

Family and domain databases

Gene3Di 3.40.1500.10. 1 hit.
InterProi IPR001260. Coprogen_oxidase_aer.
IPR018375. Coprogen_oxidase_CS.
[Graphical view ]
PANTHERi PTHR10755. PTHR10755. 1 hit.
Pfami PF01218. Coprogen_oxidas. 1 hit.
[Graphical view ]
PRINTSi PR00073. COPRGNOXDASE.
SUPFAMi SSF102886. SSF102886. 1 hit.
PROSITEi PS01021. COPROGEN_OXIDASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: ProstateImported.
  2. "Evidence that the coproporphyrinogen oxidase activity of rat liver is situated in the intermembrane space of mitochondria."
    Elder G.H., Evans J.O.
    Biochem. J. 172:345-347(1978) [PubMed] [Europe PMC] [Abstract]
    Cited for: ENZYME ACTIVITY, PATHWAY, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiHEM6_RAT
AccessioniPrimary (citable) accession number: Q3B7D0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: November 22, 2005
Last modified: November 26, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3