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Q3B7D0

- HEM6_RAT

UniProt

Q3B7D0 - HEM6_RAT

Protein

Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

Gene

Cpox

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX By similarity.By similarity

    Catalytic activityi

    Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O.1 Publication

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei233 – 2331SubstrateBy similarity
    Active sitei247 – 2471Proton donorBy similarity
    Sitei316 – 3161Important for dimerizationBy similarity

    GO - Molecular functioni

    1. coproporphyrinogen oxidase activity Source: RGD
    2. identical protein binding Source: RGD
    3. protein homodimerization activity Source: UniProtKB
    4. structural constituent of eye lens Source: Ensembl

    GO - Biological processi

    1. heme biosynthetic process Source: RGD
    2. protoporphyrinogen IX biosynthetic process Source: RGD
    3. response to arsenic-containing substance Source: RGD
    4. response to inorganic substance Source: RGD
    5. response to insecticide Source: RGD
    6. response to iron ion Source: RGD
    7. response to lead ion Source: RGD
    8. response to methylmercury Source: RGD

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Heme biosynthesis, Porphyrin biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00251; UER00322.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial (EC:1.3.3.3)
    Short name:
    COX
    Short name:
    Coprogen oxidase
    Short name:
    Coproporphyrinogenase
    Gene namesi
    Name:CpoxImported
    Synonyms:Cpo
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 11

    Organism-specific databases

    RGDi1311817. Cpox.

    Subcellular locationi

    Mitochondrion intermembrane space 1 Publication

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: RGD
    2. mitochondrial intermembrane space Source: RGD
    3. mitochondrion Source: RGD

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 9898MitochondrionBy similarityAdd
    BLAST
    Chaini99 – 443345Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrialPRO_0000293624Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei393 – 3931N6-acetyllysine; alternateBy similarity
    Modified residuei393 – 3931N6-succinyllysine; alternateBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ3B7D0.
    PRIDEiQ3B7D0.

    PTM databases

    PhosphoSiteiQ3B7D0.

    Expressioni

    Gene expression databases

    GenevestigatoriQ3B7D0.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000002257.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3B7D0.
    SMRiQ3B7D0. Positions 110-442.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni182 – 19110Important for dimerizationBy similarity
    Regioni249 – 2513Substrate bindingBy similarity
    Regioni381 – 41737Important for dimerizationBy similarityAdd
    BLAST
    Regioni400 – 4056Substrate bindingBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0408.
    GeneTreeiENSGT00390000017311.
    HOGENOMiHOG000262768.
    HOVERGENiHBG051897.
    InParanoidiQ3B7D0.
    KOiK00228.
    OMAiRYFETAN.
    OrthoDBiEOG7BZVSG.
    PhylomeDBiQ3B7D0.
    TreeFamiTF300703.

    Family and domain databases

    Gene3Di3.40.1500.10. 1 hit.
    InterProiIPR001260. Coprogen_oxidase_aer.
    IPR018375. Coprogen_oxidase_CS.
    [Graphical view]
    PANTHERiPTHR10755. PTHR10755. 1 hit.
    PfamiPF01218. Coprogen_oxidas. 1 hit.
    [Graphical view]
    PRINTSiPR00073. COPRGNOXDASE.
    SUPFAMiSSF102886. SSF102886. 1 hit.
    PROSITEiPS01021. COPROGEN_OXIDASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q3B7D0-1 [UniParc]FASTAAdd to Basket

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    MALRLGQLGS GPWWRAVRGD YAQLRAPSPR SASACVCRLP GTAGTQPRRG    50
    LGHGSSAGGG SRLGTGLAAA LAGMAGLAAA VLGHVQRAEM VPKSSGARSP 100
    SPGRLEEDGD ELARRCSTFM SSPVTELREL GRRPDDMKTK MELMIMETQA 150
    QVCRALAQVD GVADFSVDRW ERKEGGGGIT CVLQDGRVFE KAGVNISVVH 200
    GNLSEEAANQ MRSRGKALKK KDGKLPFTAM GISSVIHPKN PYAPTMHFNY 250
    RYFEVEEADG KMHWWFGGGC DLTPTYLNRE DAVHFHRTLK EACDQHGPDI 300
    YPKFKKWCDD YFFIAHRGER RGIGGIFFDD LDSPSKEEAF RFVKTCAEAV 350
    VPSYVPIVKK HCDDSYTPQD KLWQQLRRGR YVEFNLVYDR GTKFGLFTPG 400
    SRIESILMSL PLTARWEYMH SPPENSKEAE ILEVLRHPKD WVH 443
    Length:443
    Mass (Da):49,278
    Last modified:November 22, 2005 - v1
    Checksum:iC599A521060628A4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC107664 mRNA. Translation: AAI07665.1.
    RefSeqiNP_001032172.1. NM_001037095.1.
    UniGeneiRn.19581.

    Genome annotation databases

    EnsembliENSRNOT00000002257; ENSRNOP00000002257; ENSRNOG00000001654.
    GeneIDi304024.
    KEGGirno:304024.
    UCSCiRGD:1311817. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC107664 mRNA. Translation: AAI07665.1 .
    RefSeqi NP_001032172.1. NM_001037095.1.
    UniGenei Rn.19581.

    3D structure databases

    ProteinModelPortali Q3B7D0.
    SMRi Q3B7D0. Positions 110-442.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000002257.

    PTM databases

    PhosphoSitei Q3B7D0.

    Proteomic databases

    PaxDbi Q3B7D0.
    PRIDEi Q3B7D0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000002257 ; ENSRNOP00000002257 ; ENSRNOG00000001654 .
    GeneIDi 304024.
    KEGGi rno:304024.
    UCSCi RGD:1311817. rat.

    Organism-specific databases

    CTDi 1371.
    RGDi 1311817. Cpox.

    Phylogenomic databases

    eggNOGi COG0408.
    GeneTreei ENSGT00390000017311.
    HOGENOMi HOG000262768.
    HOVERGENi HBG051897.
    InParanoidi Q3B7D0.
    KOi K00228.
    OMAi RYFETAN.
    OrthoDBi EOG7BZVSG.
    PhylomeDBi Q3B7D0.
    TreeFami TF300703.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00322 .

    Miscellaneous databases

    NextBioi 652479.
    PROi Q3B7D0.

    Gene expression databases

    Genevestigatori Q3B7D0.

    Family and domain databases

    Gene3Di 3.40.1500.10. 1 hit.
    InterProi IPR001260. Coprogen_oxidase_aer.
    IPR018375. Coprogen_oxidase_CS.
    [Graphical view ]
    PANTHERi PTHR10755. PTHR10755. 1 hit.
    Pfami PF01218. Coprogen_oxidas. 1 hit.
    [Graphical view ]
    PRINTSi PR00073. COPRGNOXDASE.
    SUPFAMi SSF102886. SSF102886. 1 hit.
    PROSITEi PS01021. COPROGEN_OXIDASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: ProstateImported.
    2. "Evidence that the coproporphyrinogen oxidase activity of rat liver is situated in the intermembrane space of mitochondria."
      Elder G.H., Evans J.O.
      Biochem. J. 172:345-347(1978) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME ACTIVITY, PATHWAY, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiHEM6_RAT
    AccessioniPrimary (citable) accession number: Q3B7D0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3