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Reviewed, UniProtKB/Swiss-Prot Q3B7D0 (HEM6_RAT)

Last modified November 25, 2008. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Coproporphyrinogen III oxidase, mitochondrial
      Short name=Coproporphyrinogenase
      Short name=Coprogen oxidase
      Short name=COX
    EC=1.3.3.3
Gene names
Name: Cpox
Synonyms: Cpo
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length443 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Catalytic activity

Coproporphyrinogen-III + O(2) + 2 H(+) = protoporphyrinogen-IX + 2 CO(2) + 2 H(2)O.

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen III (O2 route): step 1/1.

Subcellular location

Mitochondrion intermembrane space.

Sequence similarities

Belongs to the aerobic coproporphyrinogen III oxidase family.

Ontologies

Keywords

   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentMitochondrion
   DomainTransit peptide
   Molecular functionOxidoreductase
   PTMAcetylation
Phosphoprotein

Gene Ontology (GO)

   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentmitochondrial intermembrane space

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncoproporphyrinogen oxidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 9898Mitochondrion By similarity
Chain99 – 443345Coproporphyrinogen III oxidase, mitochondrial
PRO_0000293624

Amino acid modifications

Modified residue991Phosphoserine By similarity
Modified residue3601N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3B7D0-1 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: C599A521060628A4

FASTA44349,278
        10         20         30         40         50         60 
MALRLGQLGS GPWWRAVRGD YAQLRAPSPR SASACVCRLP GTAGTQPRRG LGHGSSAGGG 

        70         80         90        100        110        120 
SRLGTGLAAA LAGMAGLAAA VLGHVQRAEM VPKSSGARSP SPGRLEEDGD ELARRCSTFM 

       130        140        150        160        170        180 
SSPVTELREL GRRPDDMKTK MELMIMETQA QVCRALAQVD GVADFSVDRW ERKEGGGGIT 

       190        200        210        220        230        240 
CVLQDGRVFE KAGVNISVVH GNLSEEAANQ MRSRGKALKK KDGKLPFTAM GISSVIHPKN 

       250        260        270        280        290        300 
PYAPTMHFNY RYFEVEEADG KMHWWFGGGC DLTPTYLNRE DAVHFHRTLK EACDQHGPDI 

       310        320        330        340        350        360 
YPKFKKWCDD YFFIAHRGER RGIGGIFFDD LDSPSKEEAF RFVKTCAEAV VPSYVPIVKK 

       370        380        390        400        410        420 
HCDDSYTPQD KLWQQLRRGR YVEFNLVYDR GTKFGLFTPG SRIESILMSL PLTARWEYMH 

       430        440 
SPPENSKEAE ILEVLRHPKD WVH 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
[2]"Evidence that the coproporphyrinogen oxidase activity of rat liver is situated in the intermembrane space of mitochondria."
Elder G.H., Evans J.O.
Biochem. J. 172:345-347(1978) [PubMed: 666752] [Abstract]
Cited for: ENZYME ACTIVITY, PATHWAY, SUBCELLULAR LOCATION.

Cross-references

Sequence databases

BC107664 mRNA. Translation: AAI07665.1.
RefSeqNP_001032172.1.
UniGeneRn.19581

3D structure databases

SMRQ3B7D0. Positions 110-442.
ModBaseSearch...

Genome annotation databases

EnsemblENSRNOG00000001654. Rattus norvegicus. [Contig view]
GeneID304024.
KEGGrno:304024.
NMPDRfig|10116.3.peg.6954.

Organism-specific databases

RGD1311817. Cpox.

Phylogenomic databases

HOVERGENQ3B7D0.

Gene expression databases

ArrayExpressQ3B7D0.

Family and domain databases

InterProIPR001260. Coprogen_oxidas.
[Graphical view]
Gene3DG3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
PANTHERPTHR10755. Coprogen_oxidas. 1 hit.
PfamPF01218. Coprogen_oxidas. 1 hit.
[Graphical view]
PRINTSPR00073. COPRGNOXDASE.
PROSITEPS01021. COPROGEN_OXIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio652479.

Entry information

Entry nameHEM6_RAT
AccessionPrimary (citable) accession number: Q3B7D0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: November 22, 2005
Last modified: November 25, 2008
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents