Reviewed, UniProtKB/Swiss-Prot Q3B7D0 (HEM6_RAT)

Names and origin

Protein names

Recommended name:
    Coproporphyrinogen-III oxidase, mitochondrial
      Short name=Coproporphyrinogenase
      Short name=Coprogen oxidase
      Short name=COX
    EC=1.3.3.3

Gene names

Name:	Cpox
Synonyms:	Cpo

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	443 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O. Ref.2
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. Ref.2
Subcellular location	Mitochondrion intermembrane space. Ref.2
Sequence similarities	Belongs to the aerobic coproporphyrinogen-III oxidase family.

Ontologies

Keywords
Biological process	Heme biosynthesis Porphyrin biosynthesis
Cellular component	Mitochondrion
Domain	Transit peptide
Molecular function	Oxidoreductase
PTM	Acetylation Phosphoprotein
Gene Ontology (GO)
Biological process	heme biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to arsenic Inferred from expression pattern. Source: RGD response to drug Inferred from expression pattern. Source: RGD response to mercury ion Inferred from expression pattern. Source: RGD
Cellular component	mitochondrial intermembrane space Inferred from direct assay. Source: RGD
Molecular function	coproporphyrinogen oxidase activity Inferred from direct assay. Source: RGD identical protein binding Inferred from direct assay. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 98	98	Mitochondrion By similarity UniProtKB P36552
	Chain	99 – 443	345	Coproporphyrinogen-III oxidase, mitochondrial		PRO_0000293624
Amino acid modifications
	Modified residue	99	1	Phosphoserine By similarity UniProtKB P36552
	Modified residue	360	1	N6-acetyllysine By similarity UniProtKB P36552

Sequences

	Sequence		Length	Mass (Da)
	Q3B7D0-1 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: C599A521060628A4	FASTA	443	49,278
	10 20 30 40 50 60 MALRLGQLGS GPWWRAVRGD YAQLRAPSPR SASACVCRLP GTAGTQPRRG LGHGSSAGGG 70 80 90 100 110 120 SRLGTGLAAA LAGMAGLAAA VLGHVQRAEM VPKSSGARSP SPGRLEEDGD ELARRCSTFM 130 140 150 160 170 180 SSPVTELREL GRRPDDMKTK MELMIMETQA QVCRALAQVD GVADFSVDRW ERKEGGGGIT 190 200 210 220 230 240 CVLQDGRVFE KAGVNISVVH GNLSEEAANQ MRSRGKALKK KDGKLPFTAM GISSVIHPKN 250 260 270 280 290 300 PYAPTMHFNY RYFEVEEADG KMHWWFGGGC DLTPTYLNRE DAVHFHRTLK EACDQHGPDI 310 320 330 340 350 360 YPKFKKWCDD YFFIAHRGER RGIGGIFFDD LDSPSKEEAF RFVKTCAEAV VPSYVPIVKK 370 380 390 400 410 420 HCDDSYTPQD KLWQQLRRGR YVEFNLVYDR GTKFGLFTPG SRIESILMSL PLTARWEYMH 430 440 SPPENSKEAE ILEVLRHPKD WVH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
[2]	"Evidence that the coproporphyrinogen oxidase activity of rat liver is situated in the intermembrane space of mitochondria." Elder G.H., Evans J.O. Biochem. J. 172:345-347(1978) [PubMed: 666752] [Abstract] Cited for: ENZYME ACTIVITY, PATHWAY, SUBCELLULAR LOCATION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC107664 mRNA. Translation: AAI07665.1.
IPI	IPI00191745.
RefSeq	NP_001032172.1.
UniGene	Rn.19581
3D structure databases
SMR	Q3B7D0. Positions 110-442.
ModBase	Search...
Proteomic databases
PRIDE	Q3B7D0.
Genome annotation databases
Ensembl	ENSRNOG00000001654. Rattus norvegicus. [Contig view]
GeneID	304024.
KEGG	rno:304024.
NMPDR	fig|10116.3.peg.6954.
Organism-specific databases
RGD	1311817. Cpox.
Phylogenomic databases
HOVERGEN	Q3B7D0.
OMA	Q3B7D0. VFKPWCD.
Enzyme and pathway databases
BRENDA	1.3.3.3. 248.
Gene expression databases
ArrayExpress	Q3B7D0.
Family and domain databases
InterPro	IPR001260. Coprogen_oxidas. IPR018375. Coproporphyrinogen-3_ox_CS. [Graphical view]
Gene3D	G3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
PANTHER	PTHR10755. Coprogen_oxidas. 1 hit.
Pfam	PF01218. Coprogen_oxidas. 1 hit. [Graphical view]
PRINTS	PR00073. COPRGNOXDASE.
PROSITE	PS01021. COPROGEN_OXIDASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	652479.

Entry information

Entry name

HEM6_RAT

Accession

Primary (citable) accession number: Q3B7D0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	November 22, 2005
Last modified:	June 16, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)