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Q3B7D0 (HEM6_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Coproporphyrinogen-III oxidase, mitochondrial

Short name=COX
Short name=Coprogen oxidase
Short name=Coproporphyrinogenase
EC=1.3.3.3
Gene names
Name:Cpox
Synonyms:Cpo
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length443 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III By similarity.

Catalytic activity

Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O. Ref.2

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. Ref.2

Subunit structure

Homodimer By similarity.

Subcellular location

Mitochondrion intermembrane space Ref.2.

Sequence similarities

Belongs to the aerobic coproporphyrinogen-III oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 9898Mitochondrion By similarity UniProtKB P36552
Chain99 – 443345Coproporphyrinogen-III oxidase, mitochondrial UniProtKB P36552
PRO_0000293624

Regions

Region182 – 19110Important for dimerization By similarity
Region249 – 2513Substrate binding By similarity
Region381 – 41737Important for dimerization By similarity
Region400 – 4056Substrate binding By similarity

Sites

Active site2471Proton donor By similarity
Binding site2331Substrate By similarity
Site3161Important for dimerization By similarity

Amino acid modifications

Modified residue991Phosphoserine By similarity UniProtKB P36552
Modified residue3601N6-acetyllysine By similarity UniProtKB P36552

Sequences

Sequence LengthMass (Da)Tools
Q3B7D0 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: C599A521060628A4

FASTA44349,278
        10         20         30         40         50         60 
MALRLGQLGS GPWWRAVRGD YAQLRAPSPR SASACVCRLP GTAGTQPRRG LGHGSSAGGG 

        70         80         90        100        110        120 
SRLGTGLAAA LAGMAGLAAA VLGHVQRAEM VPKSSGARSP SPGRLEEDGD ELARRCSTFM 

       130        140        150        160        170        180 
SSPVTELREL GRRPDDMKTK MELMIMETQA QVCRALAQVD GVADFSVDRW ERKEGGGGIT 

       190        200        210        220        230        240 
CVLQDGRVFE KAGVNISVVH GNLSEEAANQ MRSRGKALKK KDGKLPFTAM GISSVIHPKN 

       250        260        270        280        290        300 
PYAPTMHFNY RYFEVEEADG KMHWWFGGGC DLTPTYLNRE DAVHFHRTLK EACDQHGPDI 

       310        320        330        340        350        360 
YPKFKKWCDD YFFIAHRGER RGIGGIFFDD LDSPSKEEAF RFVKTCAEAV VPSYVPIVKK 

       370        380        390        400        410        420 
HCDDSYTPQD KLWQQLRRGR YVEFNLVYDR GTKFGLFTPG SRIESILMSL PLTARWEYMH 

       430        440 
SPPENSKEAE ILEVLRHPKD WVH 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
[2]"Evidence that the coproporphyrinogen oxidase activity of rat liver is situated in the intermembrane space of mitochondria."
Elder G.H., Evans J.O.
Biochem. J. 172:345-347(1978) [PubMed] [Europe PMC] [Abstract]
Cited for: ENZYME ACTIVITY, PATHWAY, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC107664 mRNA. Translation: AAI07665.1.
IPIIPI00191745.
RefSeqNP_001032172.1. NM_001037095.1.
UniGeneRn.19581.

3D structure databases

ProteinModelPortalQ3B7D0.
SMRQ3B7D0. Positions 110-442.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000002257.

PTM databases

PhosphoSiteQ3B7D0.

Proteomic databases

PaxDbQ3B7D0.
PRIDEQ3B7D0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000002257; ENSRNOP00000002257; ENSRNOG00000001654.
GeneID304024.
KEGGrno:304024.
UCSCRGD:1311817. rat.

Organism-specific databases

CTD1371.
RGD1311817. Cpox.

Phylogenomic databases

eggNOGCOG0408.
GeneTreeENSGT00390000017311.
HOGENOMHOG000262768.
HOVERGENHBG051897.
InParanoidQ3B7D0.
KOK00228.
OMAWFATGTS.
OrthoDBEOG41VK2W.

Enzyme and pathway databases

UniPathwayUPA00251; UER00322.

Gene expression databases

GenevestigatorQ3B7D0.

Family and domain databases

Gene3D3.40.1500.10. 1 hit.
InterProIPR001260. Coprogen_oxidase_aer.
IPR018375. Coprogen_oxidase_CS.
[Graphical view]
PANTHERPTHR10755. PTHR10755. 1 hit.
PfamPF01218. Coprogen_oxidas. 1 hit.
[Graphical view]
PRINTSPR00073. COPRGNOXDASE.
SUPFAMSSF102886. Coprogen_oxidas. 1 hit.
PROSITEPS01021. COPROGEN_OXIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio652479.

Entry information

Entry nameHEM6_RAT
AccessionPrimary (citable) accession number: Q3B7D0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: November 22, 2005
Last modified: April 3, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families