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Protein

Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

Gene

Cpox

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX (By similarity).By similarity

Catalytic activityi

Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O.1 Publication

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei233 – 2331SubstrateBy similarity
Active sitei247 – 2471Proton donorBy similarity
Sitei316 – 3161Important for dimerizationBy similarity

GO - Molecular functioni

  1. coproporphyrinogen oxidase activity Source: RGD
  2. identical protein binding Source: RGD
  3. protein homodimerization activity Source: UniProtKB
  4. structural constituent of eye lens Source: Ensembl

GO - Biological processi

  1. heme biosynthetic process Source: RGD
  2. protoporphyrinogen IX biosynthetic process Source: RGD
  3. response to arsenic-containing substance Source: RGD
  4. response to inorganic substance Source: RGD
  5. response to insecticide Source: RGD
  6. response to iron ion Source: RGD
  7. response to lead ion Source: RGD
  8. response to methylmercury Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Enzyme and pathway databases

ReactomeiREACT_336296. Heme biosynthesis.
UniPathwayiUPA00251; UER00322.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial (EC:1.3.3.3)
Short name:
COX
Short name:
Coprogen oxidase
Short name:
Coproporphyrinogenase
Gene namesi
Name:CpoxImported
Synonyms:Cpo
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi1311817. Cpox.

Subcellular locationi

Mitochondrion intermembrane space 1 Publication

GO - Cellular componenti

  1. mitochondrial inner membrane Source: RGD
  2. mitochondrial intermembrane space Source: RGD
  3. mitochondrion Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 9898MitochondrionBy similarityAdd
BLAST
Chaini99 – 443345Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrialPRO_0000293624Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei393 – 3931N6-acetyllysine; alternateBy similarity
Modified residuei393 – 3931N6-succinyllysine; alternateBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ3B7D0.
PRIDEiQ3B7D0.

PTM databases

PhosphoSiteiQ3B7D0.

Expressioni

Gene expression databases

GenevestigatoriQ3B7D0.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002257.

Structurei

3D structure databases

ProteinModelPortaliQ3B7D0.
SMRiQ3B7D0. Positions 110-442.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni182 – 19110Important for dimerizationBy similarity
Regioni249 – 2513Substrate bindingBy similarity
Regioni381 – 41737Important for dimerizationBy similarityAdd
BLAST
Regioni400 – 4056Substrate bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0408.
GeneTreeiENSGT00390000017311.
HOGENOMiHOG000262768.
HOVERGENiHBG051897.
InParanoidiQ3B7D0.
KOiK00228.
OMAiQRPEAKG.
OrthoDBiEOG7BZVSG.
PhylomeDBiQ3B7D0.
TreeFamiTF300703.

Family and domain databases

Gene3Di3.40.1500.10. 1 hit.
InterProiIPR001260. Coprogen_oxidase_aer.
IPR018375. Coprogen_oxidase_CS.
[Graphical view]
PANTHERiPTHR10755. PTHR10755. 1 hit.
PfamiPF01218. Coprogen_oxidas. 1 hit.
[Graphical view]
PRINTSiPR00073. COPRGNOXDASE.
SUPFAMiSSF102886. SSF102886. 1 hit.
PROSITEiPS01021. COPROGEN_OXIDASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3B7D0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRLGQLGS GPWWRAVRGD YAQLRAPSPR SASACVCRLP GTAGTQPRRG
60 70 80 90 100
LGHGSSAGGG SRLGTGLAAA LAGMAGLAAA VLGHVQRAEM VPKSSGARSP
110 120 130 140 150
SPGRLEEDGD ELARRCSTFM SSPVTELREL GRRPDDMKTK MELMIMETQA
160 170 180 190 200
QVCRALAQVD GVADFSVDRW ERKEGGGGIT CVLQDGRVFE KAGVNISVVH
210 220 230 240 250
GNLSEEAANQ MRSRGKALKK KDGKLPFTAM GISSVIHPKN PYAPTMHFNY
260 270 280 290 300
RYFEVEEADG KMHWWFGGGC DLTPTYLNRE DAVHFHRTLK EACDQHGPDI
310 320 330 340 350
YPKFKKWCDD YFFIAHRGER RGIGGIFFDD LDSPSKEEAF RFVKTCAEAV
360 370 380 390 400
VPSYVPIVKK HCDDSYTPQD KLWQQLRRGR YVEFNLVYDR GTKFGLFTPG
410 420 430 440
SRIESILMSL PLTARWEYMH SPPENSKEAE ILEVLRHPKD WVH
Length:443
Mass (Da):49,278
Last modified:November 22, 2005 - v1
Checksum:iC599A521060628A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107664 mRNA. Translation: AAI07665.1.
RefSeqiNP_001032172.1. NM_001037095.1.
UniGeneiRn.19581.

Genome annotation databases

EnsembliENSRNOT00000002257; ENSRNOP00000002257; ENSRNOG00000001654.
GeneIDi304024.
KEGGirno:304024.
UCSCiRGD:1311817. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107664 mRNA. Translation: AAI07665.1.
RefSeqiNP_001032172.1. NM_001037095.1.
UniGeneiRn.19581.

3D structure databases

ProteinModelPortaliQ3B7D0.
SMRiQ3B7D0. Positions 110-442.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002257.

PTM databases

PhosphoSiteiQ3B7D0.

Proteomic databases

PaxDbiQ3B7D0.
PRIDEiQ3B7D0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000002257; ENSRNOP00000002257; ENSRNOG00000001654.
GeneIDi304024.
KEGGirno:304024.
UCSCiRGD:1311817. rat.

Organism-specific databases

CTDi1371.
RGDi1311817. Cpox.

Phylogenomic databases

eggNOGiCOG0408.
GeneTreeiENSGT00390000017311.
HOGENOMiHOG000262768.
HOVERGENiHBG051897.
InParanoidiQ3B7D0.
KOiK00228.
OMAiQRPEAKG.
OrthoDBiEOG7BZVSG.
PhylomeDBiQ3B7D0.
TreeFamiTF300703.

Enzyme and pathway databases

UniPathwayiUPA00251; UER00322.
ReactomeiREACT_336296. Heme biosynthesis.

Miscellaneous databases

NextBioi652479.
PROiQ3B7D0.

Gene expression databases

GenevestigatoriQ3B7D0.

Family and domain databases

Gene3Di3.40.1500.10. 1 hit.
InterProiIPR001260. Coprogen_oxidase_aer.
IPR018375. Coprogen_oxidase_CS.
[Graphical view]
PANTHERiPTHR10755. PTHR10755. 1 hit.
PfamiPF01218. Coprogen_oxidas. 1 hit.
[Graphical view]
PRINTSiPR00073. COPRGNOXDASE.
SUPFAMiSSF102886. SSF102886. 1 hit.
PROSITEiPS01021. COPROGEN_OXIDASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: ProstateImported.
  2. "Evidence that the coproporphyrinogen oxidase activity of rat liver is situated in the intermembrane space of mitochondria."
    Elder G.H., Evans J.O.
    Biochem. J. 172:345-347(1977) [PubMed] [Europe PMC] [Abstract]
    Cited for: ENZYME ACTIVITY, PATHWAY, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiHEM6_RAT
AccessioniPrimary (citable) accession number: Q3B7D0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: November 22, 2005
Last modified: April 1, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.