Coproporphyrinogen-III oxidase, mitochondrial precursor

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Q3B7D0 (HEM6_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 60. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Coproporphyrinogen-III oxidase, mitochondrial
Short name=COX
Short name=Coprogen oxidase
Short name=Coproporphyrinogenase
EC=1.3.3.3

Gene names

Name:	Cpox
Synonyms:	Cpo

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	443 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III By similarity.
Catalytic activity	Coproporphyrinogen-III + O₂ + 2 H⁺ = protoporphyrinogen-IX + 2 CO₂ + 2 H₂O. Ref.2
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. Ref.2
Subunit structure	Homodimer By similarity.
Subcellular location	Mitochondrion intermembrane space Ref.2.
Sequence similarities	Belongs to the aerobic coproporphyrinogen-III oxidase family.

Ontologies

Keywords
Biological process	Heme biosynthesis Porphyrin biosynthesis
Cellular component	Mitochondrion
Domain	Transit peptide
Molecular function	Oxidoreductase
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protoporphyrinogen IX biosynthetic process Inferred from direct assay PubMed 3814086. Source: RGD response to arsenic-containing substance Inferred from expression pattern PubMed 2916235. Source: RGD response to insecticide Inferred from expression pattern PubMed 6626236. Source: RGD response to iron ion Inferred from expression pattern PubMed 2289051. Source: RGD response to lead ion Inferred from expression pattern PubMed 656697. Source: RGD response to methylmercury Inferred from expression pattern PubMed 2916235. Source: RGD
Cellular_component	mitochondrial inner membrane Inferred from direct assay PubMed 31872. Source: RGD mitochondrial intermembrane space Inferred from direct assay PubMed 31872. Source: RGD
Molecular_function	coproporphyrinogen oxidase activity Inferred from direct assay PubMed 11079369. Source: RGD protein homodimerization activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Transit peptide

1 – 98

Mitochondrion By similarity UniProtKB P36552

Chain

99 – 443

345

Coproporphyrinogen-III oxidase, mitochondrial UniProtKB P36552

PRO_0000293624

Regions

Region

182 – 191

Important for dimerization By similarity

Region

249 – 251

Substrate binding By similarity

Region

381 – 417

Important for dimerization By similarity

Region

400 – 405

Substrate binding By similarity

Sites

Active site

247

Proton donor By similarity

Binding site

233

Substrate By similarity

Site

316

Important for dimerization By similarity

Amino acid modifications

Modified residue

Phosphoserine By similarity UniProtKB P36552

Modified residue

360

N6-acetyllysine By similarity UniProtKB P36552

Sequences

Sequence

Length

Mass (Da)

Tools

Q3B7D0 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: C599A521060628A4
Show »

FASTA

443

49,278

        10         20         30         40         50         60 
MALRLGQLGS GPWWRAVRGD YAQLRAPSPR SASACVCRLP GTAGTQPRRG LGHGSSAGGG 

        70         80         90        100        110        120 
SRLGTGLAAA LAGMAGLAAA VLGHVQRAEM VPKSSGARSP SPGRLEEDGD ELARRCSTFM 

       130        140        150        160        170        180 
SSPVTELREL GRRPDDMKTK MELMIMETQA QVCRALAQVD GVADFSVDRW ERKEGGGGIT 

       190        200        210        220        230        240 
CVLQDGRVFE KAGVNISVVH GNLSEEAANQ MRSRGKALKK KDGKLPFTAM GISSVIHPKN 

       250        260        270        280        290        300 
PYAPTMHFNY RYFEVEEADG KMHWWFGGGC DLTPTYLNRE DAVHFHRTLK EACDQHGPDI 

       310        320        330        340        350        360 
YPKFKKWCDD YFFIAHRGER RGIGGIFFDD LDSPSKEEAF RFVKTCAEAV VPSYVPIVKK 

       370        380        390        400        410        420 
HCDDSYTPQD KLWQQLRRGR YVEFNLVYDR GTKFGLFTPG SRIESILMSL PLTARWEYMH 

       430        440 
SPPENSKEAE ILEVLRHPKD WVH

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
[2]	"Evidence that the coproporphyrinogen oxidase activity of rat liver is situated in the intermembrane space of mitochondria." Elder G.H., Evans J.O. Biochem. J. 172:345-347(1978) [PubMed] [Europe PMC] [Abstract] Cited for: ENZYME ACTIVITY, PATHWAY, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC107664 mRNA. Translation: AAI07665.1.
IPI	IPI00191745.
RefSeq	NP_001032172.1. NM_001037095.1.
UniGene	Rn.19581.
3D structure databases
ProteinModelPortal	Q3B7D0.
SMR	Q3B7D0. Positions 110-442.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000002257.
PTM databases
PhosphoSite	Q3B7D0.
Proteomic databases
PaxDb	Q3B7D0.
PRIDE	Q3B7D0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000002257; ENSRNOP00000002257; ENSRNOG00000001654.
GeneID	304024.
KEGG	rno:304024.
UCSC	RGD:1311817. rat.
Organism-specific databases
CTD	1371.
RGD	1311817. Cpox.
Phylogenomic databases
eggNOG	COG0408.
GeneTree	ENSGT00390000017311.
HOGENOM	HOG000262768.
HOVERGEN	HBG051897.
InParanoid	Q3B7D0.
KO	K00228.
OMA	WFATGTS.
OrthoDB	EOG41VK2W.
Enzyme and pathway databases
UniPathway	UPA00251; UER00322.
Gene expression databases
Genevestigator	Q3B7D0.
Family and domain databases
Gene3D	3.40.1500.10. 1 hit.
InterPro	IPR001260. Coprogen_oxidase_aer. IPR018375. Coprogen_oxidase_CS. [Graphical view]
PANTHER	PTHR10755. PTHR10755. 1 hit.
Pfam	PF01218. Coprogen_oxidas. 1 hit. [Graphical view]
PRINTS	PR00073. COPRGNOXDASE.
SUPFAM	SSF102886. Coprogen_oxidas. 1 hit.
PROSITE	PS01021. COPROGEN_OXIDASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	652479.

Entry information

Entry name

HEM6_RAT

Accession

Primary (citable) accession number: Q3B7D0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	November 22, 2005
Last modified:	April 3, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents