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Protein
Submitted name:

Ubiquitin-conjugating enzyme E2C

Gene

ube2c

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei113Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Biological processUbl conjugation pathwayUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DRE-141430. Inactivation of APC/C via direct inhibition of the APC/C complex.
R-DRE-174048. APC/C:Cdc20 mediated degradation of Cyclin B.
R-DRE-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-DRE-174154. APC/C:Cdc20 mediated degradation of Securin.
R-DRE-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-DRE-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-DRE-176407. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
R-DRE-176408. Regulation of APC/C activators between G1/S and early anaphase.
R-DRE-176409. APC/C:Cdc20 mediated degradation of mitotic proteins.
R-DRE-176412. Phosphorylation of the APC/C.
R-DRE-179409. APC-Cdc20 mediated degradation of Nek2A.
R-DRE-2467813. Separation of Sister Chromatids.
R-DRE-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-DRE-8866652. Synthesis of active ubiquitin: roles of E1 and E2 enzymes.

Names & Taxonomyi

Protein namesi
Submitted name:
Ubiquitin-conjugating enzyme E2CImported
Submitted name:
Zgc:123190Imported
Gene namesi
Name:ube2cImported
Synonyms:zgc:123190Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 6

Organism-specific databases

ZFINiZDB-GENE-051030-48. ube2c.

Expressioni

Gene expression databases

BgeeiENSDARG00000035770.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 159UBIQUITIN_CONJUGAT_2InterPro annotationAdd BLAST128

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0421. Eukaryota.
KOG4801. Eukaryota.
ENOG4111IGV. LUCA.
GeneTreeiENSGT00760000119350.
HOGENOMiHOG000233454.
HOVERGENiHBG063308.
KOiK06688.
OMAiAELWDKD.
OrthoDBiEOG091G0M7S.

Family and domain databases

CDDicd00195. UBCc. 1 hit.
Gene3Di3.10.110.10. 1 hit.
InterProiView protein in InterPro
IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
PfamiView protein in Pfam
PF00179. UQ_con. 1 hit.
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiView protein in PROSITE
PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3B745-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQNMDPAA ASTATLKGSE TSVTASKGSV SKRLQQELMT LMMSGDKGIS
60 70 80 90 100
AFPESDNLFK WIGTIDGAQG TVYEGLRYKL SLEFPSGYPY NAPRVKFITA
110 120 130 140 150
CFHPNVDENG IICLDILKDK WSALYDVRSI LLSIQSLLGE PNNDSPMNST
160 170
AAEMWDDQEA FKAHLHATYK N
Length:171
Mass (Da):18,777
Last modified:November 22, 2005 - v1
Checksum:i36D1E98E46388A21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABZ01041603 Genomic DNA. No translation available.
CABZ01041604 Genomic DNA. No translation available.
BC107825 mRNA. Translation: AAI07826.1.
RefSeqiNP_001032780.1. NM_001037691.2.
UniGeneiDr.52310.

Genome annotation databases

EnsembliENSDART00000051906; ENSDARP00000051905; ENSDARG00000035770.
GeneIDi566441.
KEGGidre:566441.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ3B745_DANRE
AccessioniPrimary (citable) accession number: Q3B745
Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2005
Last sequence update: November 22, 2005
Last modified: July 5, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported