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Protein
Submitted name:

Ubiquitin-conjugating enzyme E2C

Gene

ube2c

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionTransferaseSAAS annotation
Biological processUbl conjugation pathwayUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DRE-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
R-DRE-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-DRE-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DRE-174154 APC/C:Cdc20 mediated degradation of Securin
R-DRE-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DRE-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DRE-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-DRE-176408 Regulation of APC/C activators between G1/S and early anaphase
R-DRE-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
R-DRE-176412 Phosphorylation of the APC/C
R-DRE-179409 APC-Cdc20 mediated degradation of Nek2A
R-DRE-2467813 Separation of Sister Chromatids
R-DRE-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-DRE-69017 CDK-mediated phosphorylation and removal of Cdc6
R-DRE-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-DRE-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Submitted name:
Ubiquitin-conjugating enzyme E2CImported
Submitted name:
Zgc:123190Imported
Gene namesi
Name:ube2cImported
Synonyms:zgc:123190Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 6

Organism-specific databases

ZFINiZDB-GENE-051030-48 ube2c

Expressioni

Gene expression databases

BgeeiENSDARG00000035770

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 159UBIQUITIN_CONJUGAT_2InterPro annotationAdd BLAST128

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0421 Eukaryota
KOG4801 Eukaryota
ENOG4111IGV LUCA
GeneTreeiENSGT00760000119350
HOGENOMiHOG000233454
HOVERGENiHBG063308
KOiK06688
OMAiAELWDKD
OrthoDBiEOG091G0M7S

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q3B745-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQNMDPAA ASTATLKGSE TSVTASKGSV SKRLQQELMT LMMSGDKGIS
60 70 80 90 100
AFPESDNLFK WIGTIDGAQG TVYEGLRYKL SLEFPSGYPY NAPRVKFITA
110 120 130 140 150
CFHPNVDENG IICLDILKDK WSALYDVRSI LLSIQSLLGE PNNDSPMNST
160 170
AAEMWDDQEA FKAHLHATYK N
Length:171
Mass (Da):18,777
Last modified:November 22, 2005 - v1
Checksum:i36D1E98E46388A21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABZ01041603 Genomic DNA No translation available.
CABZ01041604 Genomic DNA No translation available.
BC107825 mRNA Translation: AAI07826.1
RefSeqiNP_001032780.1, NM_001037691.2
UniGeneiDr.52310

Genome annotation databases

EnsembliENSDART00000051906; ENSDARP00000051905; ENSDARG00000035770
GeneIDi566441
KEGGidre:566441

Similar proteinsi

Entry informationi

Entry nameiQ3B745_DANRE
AccessioniPrimary (citable) accession number: Q3B745
Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2005
Last sequence update: November 22, 2005
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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