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Protein

DNA-directed RNA polymerase I subunit RPA43

Gene

TWISTNB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription

Enzyme and pathway databases

ReactomeiR-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-5250924 B-WICH complex positively regulates rRNA expression
R-HSA-73762 RNA Polymerase I Transcription Initiation
R-HSA-73772 RNA Polymerase I Promoter Escape
R-HSA-73777 RNA Polymerase I Chain Elongation
R-HSA-73863 RNA Polymerase I Transcription Termination

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase I subunit RPA43
Alternative name(s):
Twist neighbor protein
Gene namesi
Name:TWISTNB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000105849.5
HGNCiHGNC:18027 TWISTNB
MIMi608312 gene
neXtProtiNX_Q3B726

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000105849
PharmGKBiPA134878254

Polymorphism and mutation databases

BioMutaiTWISTNB
DMDMi121942339

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002886321 – 338DNA-directed RNA polymerase I subunit RPA43Add BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei242PhosphoserineCombined sources1
Modified residuei304PhosphoserineCombined sources1
Modified residuei316PhosphoserineCombined sources1
Modified residuei322PhosphothreonineCombined sources1
Modified residuei328PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ3B726
MaxQBiQ3B726
PaxDbiQ3B726
PeptideAtlasiQ3B726
PRIDEiQ3B726

PTM databases

iPTMnetiQ3B726
PhosphoSitePlusiQ3B726

Expressioni

Tissue specificityi

Widely expressed. Expressed in all fetal and adult tissues tested, with highest expression in fetal lung, liver, and kidney, and low expression in all adult tissues.1 Publication

Gene expression databases

BgeeiENSG00000105849
CleanExiHS_TWISTNB
GenevisibleiQ3B726 HS

Organism-specific databases

HPAiHPA019071
HPA022416

Interactioni

Subunit structurei

Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits (By similarity). Interacts with RRN3/TIF-IA.By similarity1 Publication

Protein-protein interaction databases

BioGridi128759, 21 interactors
IntActiQ3B726, 6 interactors
STRINGi9606.ENSP00000222567

Structurei

3D structure databases

ProteinModelPortaliQ3B726
SMRiQ3B726
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi224 – 334Lys-richAdd BLAST111

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4134 Eukaryota
ENOG4111JD4 LUCA
GeneTreeiENSGT00390000005553
HOGENOMiHOG000060204
HOVERGENiHBG108416
InParanoidiQ3B726
KOiK03004
OMAiWEEEPKK
OrthoDBiEOG091G0JWK
PhylomeDBiQ3B726
TreeFamiTF325602

Family and domain databases

Gene3Di3.30.1490.120, 1 hit
InterProiView protein in InterPro
IPR036898 RNA_pol_Rpb7-like_N_sf
IPR005576 RNA_pol_Rpb7_N
PfamiView protein in Pfam
PF03876 SHS2_Rpb7-N, 1 hit

Sequencei

Sequence statusi: Complete.

Q3B726-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGCSEAPR PAAASDGSLV GQAGVLPCLE LPTYAAACAL VNSRYSCLVA
60 70 80 90 100
GPHQRHIALS PRYLNRKRTG IREQLDAELL RYSESLLGVP IAYDNIKVVG
110 120 130 140 150
ELGDIYDDQG HIHLNIEADF VIFCPEPGQK LMGIVNKVSS SHIGCLVHGC
160 170 180 190 200
FNASIPKPEQ LSAEQWQTME INMGDELEFE VFRLDSDAAG VFCIRGKLNI
210 220 230 240 250
TSLQFKRSEV SEEVTENGTE EAAKKPKKKK KKKDPETYEV DSGTTKLADD
260 270 280 290 300
ADDTPMEESA LQNTNNANGI WEEEPKKKKK KKKHQEVQDQ DPVFQGSDSS
310 320 330
GYQSDHKKKK KKRKHSEEAE FTPPLKCSPK RKGKSNFL
Length:338
Mass (Da):37,432
Last modified:November 22, 2005 - v1
Checksum:i6DA3829E74E5D25C
GO

Sequence cautioni

The sequence AAH14574 differs from that shown. Reason: Frameshift at position 224.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK301329 mRNA Translation: BAH13460.1
CH236948 Genomic DNA Translation: EAL24277.1
CH471073 Genomic DNA Translation: EAW93714.1
BC014574 mRNA Translation: AAH14574.1 Frameshift.
BC130298 mRNA Translation: AAI30299.1
BC130300 mRNA Translation: AAI30301.1
BK000492 Genomic DNA Translation: DAA05732.1
CCDSiCCDS34606.1
RefSeqiNP_001002926.1, NM_001002926.1
UniGeneiHs.353035

Genome annotation databases

EnsembliENST00000222567; ENSP00000222567; ENSG00000105849
GeneIDi221830
KEGGihsa:221830
UCSCiuc003sup.2 human

Similar proteinsi

Entry informationi

Entry nameiRPA43_HUMAN
AccessioniPrimary (citable) accession number: Q3B726
Secondary accession number(s): A0PJ45, B7Z724
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 22, 2005
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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