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Protein

Zinc finger and BTB domain-containing protein 24

Gene

Zbtb24

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in BMP2-induced transcription.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi159 – 17113A.T hookSequence analysisAdd
BLAST
Zinc fingeri293 – 31523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri321 – 34323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 37123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri377 – 39923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri405 – 42723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri433 – 45523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri461 – 48323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri489 – 51123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 24
Alternative name(s):
Bone morphogenetic protein-induced factor 1
Zinc finger protein 450
Gene namesi
Name:Zbtb24Imported
Synonyms:Bif1By similarity, Znf4501 Publication
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1306951. Zbtb24.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 705705Zinc finger and BTB domain-containing protein 24PRO_0000047736Add
BLAST

Proteomic databases

PaxDbiQ3B725.
PRIDEiQ3B725.

Expressioni

Gene expression databases

BgeeiENSRNOG00000000308.
GenevisibleiQ3B725. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054002.

Structurei

3D structure databases

ProteinModelPortaliQ3B725.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 10367BTBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Sequence analysis
Contains 1 A.T hook DNA-binding domain.Sequence analysis
Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri293 – 31523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri321 – 34323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 37123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri377 – 39923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri405 – 42723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri433 – 45523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri461 – 48323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri489 – 51123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129870.
HOGENOMiHOG000155762.
HOVERGENiHBG053990.
InParanoidiQ3B725.
KOiK10503.
OMAiNSVQNRQ.
OrthoDBiEOG091G02KC.
PhylomeDBiQ3B725.
TreeFamiTF332049.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3B725-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADTTPEPSG HLIVHSDTHS DTVLASLEDQ RKKGFLCDIT LIVENVHFRA
60 70 80 90 100
HKALLAASSE YFSMMFAEEG EIGQSIYMLE GMVADTFGIL LEFIYTGYLH
110 120 130 140 150
ASEKMTEQIL ATAQFLKVYD LVKAYTDFQN SHNSPKPPAL NCSGTPVVVI
160 170 180 190 200
SNKKNDPLKR KRGRPRKTNS LQEGKSELAA EGEVQLRVNN SVQNRQNFVF
210 220 230 240 250
KEDSVRLNEQ TPKEKELEPA GEPGSVEEMP AEKDENSDPK ARDGPGSQSR
260 270 280 290 300
YSKRRTRRSV KLKDYKLSGD EDDQSTAKRA TCGRQKRSSA PEARCKDCDR
310 320 330 340 350
VFKYSHFLAI HQRRHTGERP FKCSECGKGF AQKHSLQVHT RMHTGERPYT
360 370 380 390 400
CTVCSKALTT KHSLLEHMSL HSGQKSFTCD QCGKYFSQKR QLKSHYRVHT
410 420 430 440 450
GHSLPECNHC HRKFMDVSQL KKHLRTHTGE KPFTCEICGK SFTAKSSLQT
460 470 480 490 500
HIRIHRGEKP YSCSICGKCF SDSSAKRRHC VLHTGKKPFS CPECSLQFAR
510 520 530 540 550
LDNLKAHLKI HSKEKHASDS SSVSGSSADE VRNVLQLQPY QLSASGEQEI
560 570 580 590 600
QLLVTDSVHN INFMPTPSQG VSIVAAESSQ NMATDPAANI TLLTQQPEQL
610 620 630 640 650
QGLILSAQQE QTEHIQSLGM IGSQMDTSQT EPVHVITLSK ETLEHLHAHQ
660 670 680 690 700
EQTSSSVPAA DTGARASSPP STRPGAELTQ APLTVPLDPS PGATVGGVAL

WAVLL
Length:705
Mass (Da):78,207
Last modified:November 22, 2005 - v1
Checksum:i29562DF811332BF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC129792 Genomic DNA. No translation available.
BK001278 mRNA. Translation: DAA01248.1.
RefSeqiNP_001092137.1. NM_001098667.1.
XP_008771224.1. XM_008773002.1.
UniGeneiRn.43308.

Genome annotation databases

EnsembliENSRNOT00000057175; ENSRNOP00000054002; ENSRNOG00000000308.
GeneIDi365590.
KEGGirno:365590.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC129792 Genomic DNA. No translation available.
BK001278 mRNA. Translation: DAA01248.1.
RefSeqiNP_001092137.1. NM_001098667.1.
XP_008771224.1. XM_008773002.1.
UniGeneiRn.43308.

3D structure databases

ProteinModelPortaliQ3B725.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054002.

Proteomic databases

PaxDbiQ3B725.
PRIDEiQ3B725.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000057175; ENSRNOP00000054002; ENSRNOG00000000308.
GeneIDi365590.
KEGGirno:365590.

Organism-specific databases

CTDi9841.
RGDi1306951. Zbtb24.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129870.
HOGENOMiHOG000155762.
HOVERGENiHBG053990.
InParanoidiQ3B725.
KOiK10503.
OMAiNSVQNRQ.
OrthoDBiEOG091G02KC.
PhylomeDBiQ3B725.
TreeFamiTF332049.

Miscellaneous databases

PROiQ3B725.

Gene expression databases

BgeeiENSRNOG00000000308.
GenevisibleiQ3B725. RN.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZBT24_RAT
AccessioniPrimary (citable) accession number: Q3B725
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: November 22, 2005
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.