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Q3B5R1

- PUR9_PELLD

UniProt

Q3B5R1 - PUR9_PELLD

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Pelodictyon luteolum (strain DSM 273) (Chlorobium luteolum (strain DSM 273))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciPLUT319225:GHDM-444-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:Plut_0432
    OrganismiPelodictyon luteolum (strain DSM 273) (Chlorobium luteolum (strain DSM 273))
    Taxonomic identifieri319225 [NCBI]
    Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupPelodictyon
    ProteomesiUP000002709: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 524524Bifunctional purine biosynthesis protein PurHPRO_1000018923Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi319225.Plut_0432.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3B5R1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230373.
    KOiK00602.
    OMAiRAFKTDP.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3B5R1-1 [UniParc]FASTAAdd to Basket

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    MSDPLIKRAL VSVSDKTGIV DFCRELSSLG VEIFSTGGTL KALQDSGVKA    50
    ASISLITGFP EIMDGRVKTL HPKIHGGLLA VRDNADHVAQ AVENGIGFID 100
    MVVVNLYPFE ATVARPGVSF EDAIENIDIG GPSMLRSAAK NNESVTVLTD 150
    SADYPCVLAE MRSSGGRTTR ATRLRLARQV FQLTSRYDGA IARYLTGAEG 200
    AAPAAAETMT VKLERELDMR YGENPHQSAG FYTLTDGEGT RSFGDYFEKL 250
    HGKELSYNNM LDIAAASGLV EEFRGEEPSV VIIKHTNPCG VAQAPTLVEA 300
    WHNAFATDTQ APFGGIIAFN RPLDMVTAEA VNGIFTEILI APSYEEGVLD 350
    LLMKKKDRRL LVQKQALPKG GWEFKSTPFG MLVQERDSKI VAREDLNVVT 400
    KRQPTEEELG DLMFAWKICK HIKSNTILYV KNRRTFGVGA GQMSRVDSSK 450
    IARWKASEVN LDLHGSVVAS DAFFPFADGL LAAAEAGVTA VIQPGGSIRD 500
    NEVIEAADAN NLAMVFTGMR HFKH 524
    Length:524
    Mass (Da):56,876
    Last modified:November 22, 2005 - v1
    Checksum:iB4B6EBFC53C4587B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000096 Genomic DNA. Translation: ABB23320.1.
    RefSeqiWP_011357195.1. NC_007512.1.
    YP_374363.1. NC_007512.1.

    Genome annotation databases

    EnsemblBacteriaiABB23320; ABB23320; Plut_0432.
    GeneIDi3745358.
    KEGGiplt:Plut_0432.
    PATRICi21378334. VBIChlLut1287_0452.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000096 Genomic DNA. Translation: ABB23320.1 .
    RefSeqi WP_011357195.1. NC_007512.1.
    YP_374363.1. NC_007512.1.

    3D structure databases

    ProteinModelPortali Q3B5R1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 319225.Plut_0432.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB23320 ; ABB23320 ; Plut_0432 .
    GeneIDi 3745358.
    KEGGi plt:Plut_0432.
    PATRICi 21378334. VBIChlLut1287_0452.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230373.
    KOi K00602.
    OMAi RAFKTDP.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci PLUT319225:GHDM-444-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Pelodictyon luteolum DSM 273."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Bryant D., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 273.

    Entry informationi

    Entry nameiPUR9_PELLD
    AccessioniPrimary (citable) accession number: Q3B5R1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3