Q3B2Q0 (ADE_PELLD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenine deaminase
Short name=ADE
EC=3.5.4.2

Alternative name(s):
Adenine aminohydrolase
Short name=AAH

Gene names

Ordered Locus Names:

Plut_1524

Organism

Pelodictyon luteolum (strain DSM 273) (Chlorobium luteolum (strain DSM 273)) [Complete proteome] [HAMAP]

Taxonomic identifier

319225 [NCBI]

Taxonomic lineage

Bacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobium/Pelodictyon group › Pelodictyon

Protein attributes

Sequence length	341 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism By similarity. HAMAP MF_01962
Catalytic activity	Adenine + H2O = hypoxanthine + NH3. HAMAP MF_01962
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_01962
Sequence similarities	Belongs to the adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	adenine deaminase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 341	341	Adenine deaminase HAMAP MF_01962		PRO_1000081927
Sites
	Active site	200	1	Proton donor By similarity
	Metal binding	17	1	Zinc; catalytic By similarity
	Metal binding	19	1	Zinc; catalytic By similarity
	Metal binding	197	1	Zinc; catalytic By similarity
	Metal binding	278	1	Zinc; catalytic By similarity
	Binding site	279	1	Substrate By similarity
	Site	221	1	Important for catalytic activity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3B2Q0 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: C98C6EC13A50AA52	FASTA	341	38,253
	10 20 30 40 50 60 MTTVPCFIAG LPKAELHLHI EGTLEPAMML RLAERNRQPP PFPDVETAEK AYRFTNLQSF 70 80 90 100 110 120 LDIYYRSTEV LVTEEDFYDL TLAYLEKAAS QKIGHAEIFF DPQAHTVRGI AFATVLRGME 130 140 150 160 170 180 EACREAHSRL GISTRLIMCI LRHLSEQEGM TMLNEAVRWK RWITGIGLDS SERGNPPSKF 190 200 210 220 230 240 HNLYREARRE GFFLTAHAGE EGSAASVKET LDLLHVDRID HGVRCMDDPA LVKELVRRAV 250 260 270 280 290 300 PLTVCPLSNV KLQVFGSMQE HNLKAMLEKG LMVTLNSDDP AYFGGYLNDN FTAAAEALDL 310 320 330 340 SFSDIIRLAA NSFNASMLSI VQKKIHLLEL ADYARGFAPG H

References

[1]

"Complete sequence of Pelodictyon luteolum DSM 273." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Bryant D., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 273.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000096 Genomic DNA. Translation: ABB24381.1.
RefSeq	YP_375424.1. NC_007512.1.
3D structure databases
ProteinModelPortal	Q3B2Q0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3B2Q0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3745150.
GenomeReviews	Gene locus Plut_1524 in contig CP000096_GR.
KEGG	plt:Plut_1524.
NMPDR	fig|319225.3.peg.1506.
PATRIC	21380686. VBIChlLut1287_1601.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1816.
HOGENOM	HBG630382.
OMA	FGGYVDD.
PhylomeDB	Q3B2Q0.
ProtClustDB	PRK09358.
Enzyme and pathway databases
BioCyc	PLUT319225:PLUT_1524-MONOMER.
Family and domain databases
HAMAP	MF_01962. Adenine_deaminase. [Tree]
InterPro	IPR001365. A/AMP_deaminase_dom. IPR006330. A_deaminase. [Graphical view]
KO	K01488.
PANTHER	PTHR11409:SF21. PTHR11409:SF21. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. Aden_deam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ADE_PELLD

Accession

Primary (citable) accession number: Q3B2Q0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	November 22, 2005
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program