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Q3B2G3 (GCSPA_PELLD) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:Plut_1614
OrganismPelodictyon luteolum (strain DSM 273) (Chlorobium luteolum (strain DSM 273)) [Complete proteome] [HAMAP]
Taxonomic identifier319225 [NCBI]
Taxonomic lineageBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupPelodictyon

Protein attributes

Sequence length444 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 444444Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000045674

Sequences

Sequence LengthMass (Da)Tools
Q3B2G3 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: DE3FAF65B6428993

FASTA44447,680
        10         20         30         40         50         60 
MPFIVNTDAD RESMLHATGV SSFDELIVDI PREVRLNKAL ELAPAADEME VRSILESMAA 

        70         80         90        100        110        120 
ANRSTADYVS FLGGGAYDHF LPSAIKAIVS RSEFYTAYTP YQAEVSQGTL QAIYEYQSLI 

       130        140        150        160        170        180 
CRLYGMDVTN ASMYDGATAL AEAVLMAIGV NGRQKVVVAG KLHPWNSSVL KTYLEASDHS 

       190        200        210        220        230        240 
AVVQNVVEDG VGSIEVLKGL MDDTVAAVVV QQPNFYGCLE DVEAIGRLAH EHGALFIVSA 

       250        260        270        280        290        300 
NPVSLGVLEA PGAYGADISV GEGQPLGSSQ SFGGPYLGIF SVRQELVRKL PGRLVGMTKD 

       310        320        330        340        350        360 
SNGQDGFILT LQTREQHIRR EKATSNICSN QALNALQAAV YLSLLGKQGL SEVAGQSLSR 

       370        380        390        400        410        420 
AHYLAGRIAA IPGFSIRYNA PFFNEFVVDT PIPPSEVVRK MLEKKVFAGC DLGEFGDEGL 

       430        440 
LVAVTEKRTK AQLDMFADAL GELA 

« Hide

References

[1]"Complete sequence of Pelodictyon luteolum DSM 273."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Bryant D., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 273.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000096 Genomic DNA. Translation: ABB24468.1.
RefSeqYP_375511.1. NC_007512.1.

3D structure databases

ProteinModelPortalQ3B2G3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING319225.Plut_1614.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB24468; ABB24468; Plut_1614.
GeneID3744986.
KEGGplt:Plut_1614.
PATRIC21380870. VBIChlLut1287_1693.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMARLVGQTE.
OrthoDBEOG6XWV3B.

Enzyme and pathway databases

BioCycPLUT319225:GHDM-1619-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_PELLD
AccessionPrimary (citable) accession number: Q3B2G3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 22, 2005
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families