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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Chlorobium luteolum (strain DSM 273 / 2530) (Pelodictyon luteolum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciCLUT319225:G1G4U-1720-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Plut_1614
OrganismiChlorobium luteolum (strain DSM 273 / 2530) (Pelodictyon luteolum)
Taxonomic identifieri319225 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupPelodictyon
Proteomesi
  • UP000002709 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000456741 – 444Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST444

Proteomic databases

PRIDEiQ3B2G3

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi319225.Plut_1614

Structurei

3D structure databases

ProteinModelPortaliQ3B2G3
SMRiQ3B2G3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QK8 Bacteria
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q3B2G3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFIVNTDAD RESMLHATGV SSFDELIVDI PREVRLNKAL ELAPAADEME
60 70 80 90 100
VRSILESMAA ANRSTADYVS FLGGGAYDHF LPSAIKAIVS RSEFYTAYTP
110 120 130 140 150
YQAEVSQGTL QAIYEYQSLI CRLYGMDVTN ASMYDGATAL AEAVLMAIGV
160 170 180 190 200
NGRQKVVVAG KLHPWNSSVL KTYLEASDHS AVVQNVVEDG VGSIEVLKGL
210 220 230 240 250
MDDTVAAVVV QQPNFYGCLE DVEAIGRLAH EHGALFIVSA NPVSLGVLEA
260 270 280 290 300
PGAYGADISV GEGQPLGSSQ SFGGPYLGIF SVRQELVRKL PGRLVGMTKD
310 320 330 340 350
SNGQDGFILT LQTREQHIRR EKATSNICSN QALNALQAAV YLSLLGKQGL
360 370 380 390 400
SEVAGQSLSR AHYLAGRIAA IPGFSIRYNA PFFNEFVVDT PIPPSEVVRK
410 420 430 440
MLEKKVFAGC DLGEFGDEGL LVAVTEKRTK AQLDMFADAL GELA
Length:444
Mass (Da):47,680
Last modified:November 22, 2005 - v1
Checksum:iDE3FAF65B6428993
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000096 Genomic DNA Translation: ABB24468.1
RefSeqiWP_011358340.1, NC_007512.1

Genome annotation databases

EnsemblBacteriaiABB24468; ABB24468; Plut_1614
KEGGiplt:Plut_1614

Similar proteinsi

Entry informationi

Entry nameiGCSPA_CHLL7
AccessioniPrimary (citable) accession number: Q3B2G3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 22, 2005
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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