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Q3B2E3

- PANC_PELLD

UniProt

Q3B2E3 - PANC_PELLD

Protein

Pantothenate synthetase

Gene

panC

Organism
Pelodictyon luteolum (strain DSM 273) (Chlorobium luteolum (strain DSM 273))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei37 – 371Proton donorUniRule annotation
    Binding sitei61 – 611Beta-alanineUniRule annotation
    Binding sitei61 – 611PantoateUniRule annotation
    Binding sitei153 – 1531PantoateUniRule annotation
    Binding sitei176 – 1761ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi30 – 378ATPUniRule annotation
    Nucleotide bindingi147 – 1504ATPUniRule annotation
    Nucleotide bindingi184 – 1874ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPLUT319225:GHDM-1639-MONOMER.
    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
    Short name:
    PSUniRule annotation
    Alternative name(s):
    Pantoate--beta-alanine ligaseUniRule annotation
    Pantoate-activating enzymeUniRule annotation
    Gene namesi
    Name:panCUniRule annotation
    Ordered Locus Names:Plut_1634
    OrganismiPelodictyon luteolum (strain DSM 273) (Chlorobium luteolum (strain DSM 273))
    Taxonomic identifieri319225 [NCBI]
    Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupPelodictyon
    ProteomesiUP000002709: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 283283Pantothenate synthetasePRO_0000305508Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi319225.Plut_1634.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3B2E3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pantothenate synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0414.
    HOGENOMiHOG000175516.
    KOiK01918.
    OMAiIHTIREL.
    OrthoDBiEOG6Z6FZ4.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    InterProiIPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
    PfamiPF02569. Pantoate_ligase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00018. panC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3B2E3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQIVTDPAEM QATADKLRAG RQLIGVVMTM GALHEGHLSL VNLAREHAGT    50
    IIMTLFVNPS QFGPGEDFQR YPRPFEKDAA MARSAGVDYL FAPTPEAMYP 100
    EGFQTTVSCS GITRRFEGER RPGHFDGVAT IVSKLLNITR PHVAVFGEKD 150
    AQQLALIRRI NRDLDMGVQI VAAPTVREND GLAVSSRNIY LTGDERQKAP 200
    AIHRAIQHAG EMLAAGENDL KAVAAEVAGM ITENTQFKLE YAAFVDEESF 250
    EPAETVVKEH EYRLLIAAAA ERVRLIDNQK FRV 283
    Length:283
    Mass (Da):31,218
    Last modified:November 22, 2005 - v1
    Checksum:iF2C5F5788C72EF70
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000096 Genomic DNA. Translation: ABB24488.1.
    RefSeqiYP_375531.1. NC_007512.1.

    Genome annotation databases

    EnsemblBacteriaiABB24488; ABB24488; Plut_1634.
    GeneIDi3746140.
    KEGGiplt:Plut_1634.
    PATRICi21380910. VBIChlLut1287_1713.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000096 Genomic DNA. Translation: ABB24488.1 .
    RefSeqi YP_375531.1. NC_007512.1.

    3D structure databases

    ProteinModelPortali Q3B2E3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 319225.Plut_1634.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB24488 ; ABB24488 ; Plut_1634 .
    GeneIDi 3746140.
    KEGGi plt:Plut_1634.
    PATRICi 21380910. VBIChlLut1287_1713.

    Phylogenomic databases

    eggNOGi COG0414.
    HOGENOMi HOG000175516.
    KOi K01918.
    OMAi IHTIREL.
    OrthoDBi EOG6Z6FZ4.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .
    BioCyci PLUT319225:GHDM-1639-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    InterProi IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
    Pfami PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00018. panC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Pelodictyon luteolum DSM 273."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Bryant D., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 273.

    Entry informationi

    Entry nameiPANC_PELLD
    AccessioniPrimary (citable) accession number: Q3B2E3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3