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Q3B2E1 (SYL_PELLD) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:Plut_1636
OrganismPelodictyon luteolum (strain DSM 273) (Chlorobium luteolum (strain DSM 273)) [Complete proteome] [HAMAP]
Taxonomic identifier319225 [NCBI]
Taxonomic lineageBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupPelodictyon

Protein attributes

Sequence length805 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 805805Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_1000009388

Regions

Motif40 – 5112"HIGH" region HAMAP-Rule MF_00049
Motif576 – 5805"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site5791ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3B2E1 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: C5D33F532F3DD313

FASTA80591,936
        10         20         30         40         50         60 
MKYDFSHTEK KWQAYWQEHG TFQAEEGQEK PKYYVLDMFP YPSGSGLHVG HLEGYTASDI 

        70         80         90        100        110        120 
VARYRRSRGN NVLHPMGWDA FGLPAEQYAI KTGTHPSLTT ENNIRSFRET LQAMGFSYDW 

       130        140        150        160        170        180 
SREINTTDPG YFRWTQWIFL KLYEMGLAYQ SEVDVNWCVE LRAVLANEEV EEKIAEGLTV 

       190        200        210        220        230        240 
VRRPLRQWVL KITAYAERLL LDLDGLDWPE NVKQMQRNWI GRSEGVEVDF ELRCHRKMLR 

       250        260        270        280        290        300 
VYTTRPDTLF GATYLVISPE HPMAEKLATA PQLVEVKNYI SKAKLKTELE RTGLQKDKTG 

       310        320        330        340        350        360 
VFTGSYAINP ANGEALPVWI SDFVLTSYGT GAIMSVPAHD SRDWEFAKKF GLPIVEVVKS 

       370        380        390        400        410        420 
PHDVQDAVYE GKDSTAVNSS NSEISLDGLA FPEAFERMAS WLELKKCGER KVNYRLRDWI 

       430        440        450        460        470        480 
FSRQRYWGEP IPVKHYEDGS LGTETDLPLR LPEVEAYQPT ETGESPLANI PEWLYGTDGK 

       490        500        510        520        530        540 
GAFRRETNTM PQWAGSCWYY LRFIDPRNSE HLVDAEKEHY WMNVDLYIGG AEHAVLHLLY 

       550        560        570        580        590        600 
ARFWHKVLYD LKVVSTKEPF QKLFNQGMIL GEDGEKMSKS RGNVIPADHV LEKYGADAVR 

       610        620        630        640        650        660 
LYEMFLGPLE QVKPWNTNGI EGVSRFLNRV WRLVHPDTEG PAAVLDEAAM PGELLRRMHK 

       670        680        690        700        710        720 
TVKKVREDTE CLKFNTAIAE MMVFVNDLHR TGNRNREAIE TLVLLLAPYA PHISEELWEA 

       730        740        750        760        770        780 
LGHPESIARA PFPTFDPALA ANDVLTIAVQ VNGKLRGTFE AAKDASKEEM LEAARAVESV 

       790        800 
RKFIEGSTVV KEIVVPGKLI NFAVK 

« Hide

References

[1]"Complete sequence of Pelodictyon luteolum DSM 273."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Bryant D., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 273.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000096 Genomic DNA. Translation: ABB24490.1.
RefSeqYP_375533.1. NC_007512.1.

3D structure databases

ProteinModelPortalQ3B2E1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING319225.Plut_1636.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB24490; ABB24490; Plut_1636.
GeneID3746142.
KEGGplt:Plut_1636.
PATRIC21380914. VBIChlLut1287_1715.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200748.
KOK01869.
OMAHISHELW.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycPLUT319225:GHDM-1641-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYL_PELLD
AccessionPrimary (citable) accession number: Q3B2E1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 22, 2005
Last modified: May 14, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries