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Q3B2E1

- SYL_PELLD

UniProt

Q3B2E1 - SYL_PELLD

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Protein

Leucine--tRNA ligase

Gene
leuS, Plut_1636
Organism
Pelodictyon luteolum (strain DSM 273) (Chlorobium luteolum (strain DSM 273))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei579 – 5791ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPLUT319225:GHDM-1641-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Plut_1636
OrganismiPelodictyon luteolum (strain DSM 273) (Chlorobium luteolum (strain DSM 273))
Taxonomic identifieri319225 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupPelodictyon
ProteomesiUP000002709: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 805805Leucine--tRNA ligaseUniRule annotationPRO_1000009388Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi319225.Plut_1636.

Structurei

3D structure databases

ProteinModelPortaliQ3B2E1.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionUniRule annotationAdd
BLAST
Motifi576 – 5805"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3B2E1-1 [UniParc]FASTAAdd to Basket

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MKYDFSHTEK KWQAYWQEHG TFQAEEGQEK PKYYVLDMFP YPSGSGLHVG    50
HLEGYTASDI VARYRRSRGN NVLHPMGWDA FGLPAEQYAI KTGTHPSLTT 100
ENNIRSFRET LQAMGFSYDW SREINTTDPG YFRWTQWIFL KLYEMGLAYQ 150
SEVDVNWCVE LRAVLANEEV EEKIAEGLTV VRRPLRQWVL KITAYAERLL 200
LDLDGLDWPE NVKQMQRNWI GRSEGVEVDF ELRCHRKMLR VYTTRPDTLF 250
GATYLVISPE HPMAEKLATA PQLVEVKNYI SKAKLKTELE RTGLQKDKTG 300
VFTGSYAINP ANGEALPVWI SDFVLTSYGT GAIMSVPAHD SRDWEFAKKF 350
GLPIVEVVKS PHDVQDAVYE GKDSTAVNSS NSEISLDGLA FPEAFERMAS 400
WLELKKCGER KVNYRLRDWI FSRQRYWGEP IPVKHYEDGS LGTETDLPLR 450
LPEVEAYQPT ETGESPLANI PEWLYGTDGK GAFRRETNTM PQWAGSCWYY 500
LRFIDPRNSE HLVDAEKEHY WMNVDLYIGG AEHAVLHLLY ARFWHKVLYD 550
LKVVSTKEPF QKLFNQGMIL GEDGEKMSKS RGNVIPADHV LEKYGADAVR 600
LYEMFLGPLE QVKPWNTNGI EGVSRFLNRV WRLVHPDTEG PAAVLDEAAM 650
PGELLRRMHK TVKKVREDTE CLKFNTAIAE MMVFVNDLHR TGNRNREAIE 700
TLVLLLAPYA PHISEELWEA LGHPESIARA PFPTFDPALA ANDVLTIAVQ 750
VNGKLRGTFE AAKDASKEEM LEAARAVESV RKFIEGSTVV KEIVVPGKLI 800
NFAVK 805
Length:805
Mass (Da):91,936
Last modified:November 22, 2005 - v1
Checksum:iC5D33F532F3DD313
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000096 Genomic DNA. Translation: ABB24490.1.
RefSeqiWP_011358362.1. NC_007512.1.
YP_375533.1. NC_007512.1.

Genome annotation databases

EnsemblBacteriaiABB24490; ABB24490; Plut_1636.
GeneIDi3746142.
KEGGiplt:Plut_1636.
PATRICi21380914. VBIChlLut1287_1715.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000096 Genomic DNA. Translation: ABB24490.1 .
RefSeqi WP_011358362.1. NC_007512.1.
YP_375533.1. NC_007512.1.

3D structure databases

ProteinModelPortali Q3B2E1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 319225.Plut_1636.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB24490 ; ABB24490 ; Plut_1636 .
GeneIDi 3746142.
KEGGi plt:Plut_1636.
PATRICi 21380914. VBIChlLut1287_1715.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PLUT319225:GHDM-1641-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Pelodictyon luteolum DSM 273."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Bryant D., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 273.

Entry informationi

Entry nameiSYL_PELLD
AccessioniPrimary (citable) accession number: Q3B2E1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 22, 2005
Last modified: September 3, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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