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Protein

Malonyl-[acyl-carrier protein] O-methyltransferase

Gene

bioC

Organism
Chlorobium luteolum (strain DSM 273 / 2530) (Pelodictyon luteolum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + malonyl-[acyl-carrier protein] = S-adenosyl-L-homocysteine + malonyl-[acyl-carrier protein] methyl ester.UniRule annotation

Pathwayi: biotin biosynthesis

This protein is involved in the pathway biotin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway biotin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processBiotin biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciCLUT319225:G1G4U-2189-MONOMER
UniPathwayiUPA00078

Names & Taxonomyi

Protein namesi
Recommended name:
Malonyl-[acyl-carrier protein] O-methyltransferaseUniRule annotation (EC:2.1.1.197UniRule annotation)
Short name:
Malonyl-ACP O-methyltransferaseUniRule annotation
Alternative name(s):
Biotin synthesis protein BioCUniRule annotation
Gene namesi
Name:bioCUniRule annotation
Ordered Locus Names:Plut_2067
OrganismiChlorobium luteolum (strain DSM 273 / 2530) (Pelodictyon luteolum)
Taxonomic identifieri319225 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupPelodictyon
Proteomesi
  • UP000002709 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004125161 – 263Malonyl-[acyl-carrier protein] O-methyltransferaseAdd BLAST263

Interactioni

Protein-protein interaction databases

STRINGi319225.Plut_2067

Structurei

3D structure databases

ProteinModelPortaliQ3B172
SMRiQ3B172
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG41090JN Bacteria
ENOG4111P8N LUCA
HOGENOMiHOG000003262
KOiK02169
OMAiSADYWLF
OrthoDBiPOG091H05JY

Family and domain databases

HAMAPiMF_00835 BioC, 1 hit
InterProiView protein in InterPro
IPR011814 BioC
IPR013216 Methyltransf_11
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF08241 Methyltransf_11, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR02072 BioC, 1 hit

Sequencei

Sequence statusi: Complete.

Q3B172-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLTDKALV RERFRRTLGS YAGEAAVQRA MAQELVSMAA RHASGIHFER
60 70 80 90 100
VLEVGSGSGM LTELMLEAFS IERYTANDLV EESRECLQGI MDRHPEVVFN
110 120 130 140 150
FLGGDVESLP FLPERRDLVV SNATLQWLDD LETFLGRIAD SMAPGGLFLF
160 170 180 190 200
TSFSSSNMQE IAAILGTALT YRSIAETGEL CERYFEVLEL REAEITLTFS
210 220 230 240 250
SPEAVLRHIS RTGVNALARK PWTKGRQKEF SDRYRSMFSQ AEGVRLTYNP
260
VYCCLRKRQE GSL
Length:263
Mass (Da):29,527
Last modified:November 22, 2005 - v1
Checksum:i0DE89FD0FFB43AD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000096 Genomic DNA Translation: ABB24909.1
RefSeqiWP_011358779.1, NC_007512.1

Genome annotation databases

EnsemblBacteriaiABB24909; ABB24909; Plut_2067
KEGGiplt:Plut_2067

Similar proteinsi

Entry informationi

Entry nameiBIOC_CHLL7
AccessioniPrimary (citable) accession number: Q3B172
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: November 22, 2005
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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