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Q3B083

- PUR9_SYNS9

UniProt

Q3B083 - PUR9_SYNS9

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Synechococcus sp. (strain CC9902)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciSSP316279:GJCI-274-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:Syncc9902_0272
    OrganismiSynechococcus sp. (strain CC9902)
    Taxonomic identifieri316279 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000002712: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 520520Bifunctional purine biosynthesis protein PurHPRO_1000018981Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi316279.Syncc9902_0272.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3B083.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230373.
    KOiK00602.
    OMAiRAFKTDP.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3B083-1 [UniParc]FASTAAdd to Basket

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    MAPVALLSVS DKSGLLPLAE ALHRIHGYQL LSSGGTAKVL EQAGLPVTRV    50
    SEYTGAPEIL GGRVKTLHPR VHGGILAKRG DAAHQNDLEQ QNINFIDVVV 100
    VNLYPFRETV AKADVTWDQA IENIDIGGPT MVRSAAKNHA DVAVLTSPDQ 150
    YDRLLEAMAQ AGGEVPAALR RQLALEAFQH TAAYDTAISR WMDQAVAADG 200
    SPWLEAVPLR QTLRYGENPH QKARWYSHAQ QGWGGAVQLQ GKELSTNNLL 250
    DLEAALAMVR EFGYGSDGAE PAVQPAAVVV KHTNPCGVAI GSDVSTALTR 300
    ALDADRVSAF GGIVAINGVV SAAAAGELKS LFLECVVAPS FSPEAREILA 350
    AKANLRLLEL QPAAIDAAGP DHVRSILGGL LVQDLDDQAI TPSEWTVASQ 400
    RPPSSQEQQD LEFAWRLVRH VRSNAIVVAS KGQSLGIGAG QMNRVGSARL 450
    ALDAAGDQAT GAVLASDGFF PFDDTVRLAA SHGITAVIHP GGSLRDADSI 500
    KACDELGLAM LLTGRRHFLH 520
    Length:520
    Mass (Da):55,018
    Last modified:November 22, 2005 - v1
    Checksum:i39883258022C7E60
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000097 Genomic DNA. Translation: ABB25245.1.
    RefSeqiWP_011359105.1. NC_007513.1.
    YP_376288.1. NC_007513.1.

    Genome annotation databases

    EnsemblBacteriaiABB25245; ABB25245; Syncc9902_0272.
    GeneIDi3742317.
    KEGGisye:Syncc9902_0272.
    PATRICi23797609. VBISynSp76179_0279.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000097 Genomic DNA. Translation: ABB25245.1 .
    RefSeqi WP_011359105.1. NC_007513.1.
    YP_376288.1. NC_007513.1.

    3D structure databases

    ProteinModelPortali Q3B083.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 316279.Syncc9902_0272.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB25245 ; ABB25245 ; Syncc9902_0272 .
    GeneIDi 3742317.
    KEGGi sye:Syncc9902_0272.
    PATRICi 23797609. VBISynSp76179_0279.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230373.
    KOi K00602.
    OMAi RAFKTDP.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci SSP316279:GJCI-274-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Synechococcus sp. CC9902."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CC9902.

    Entry informationi

    Entry nameiPUR9_SYNS9
    AccessioniPrimary (citable) accession number: Q3B083
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3