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Q3AZZ7

- UPPP_SYNS9

UniProt

Q3AZZ7 - UPPP_SYNS9

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Synechococcus sp. (strain CC9902)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciSSP316279:GJCI-363-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:Syncc9902_0358
    OrganismiSynechococcus sp. (strain CC9902)
    Taxonomic identifieri316279 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000002712: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 283283Undecaprenyl-diphosphatasePRO_0000250273Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi316279.Syncc9902_0358.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei46 – 6621HelicalUniRule annotationAdd
    BLAST
    Transmembranei95 – 11521HelicalUniRule annotationAdd
    BLAST
    Transmembranei127 – 14721HelicalUniRule annotationAdd
    BLAST
    Transmembranei154 – 17421HelicalUniRule annotationAdd
    BLAST
    Transmembranei200 – 22021HelicalUniRule annotationAdd
    BLAST
    Transmembranei227 – 24721HelicalUniRule annotationAdd
    BLAST
    Transmembranei259 – 27921HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiFNDAHAK.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3AZZ7-1 [UniParc]FASTAAdd to Basket

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    MIDTTAPLSL LEALVLGIVQ GLTEFLPISS TAHLRVVPAL LGWDDPGVSV    50
    TAAIQLGSVA AVIAYFRRDL TQVLTGISRA VRHGQWRDPD ARLGVAMVIG 100
    TLPILVLGLG IKFFWHAGYA SSPLRSVPSI AIVSIVMALF LAMAECMGPR 150
    LKQLGGVTGR DGFVVGLAQA LAVIPGVSRS GSTLTASLFD GWNRADAARF 200
    SFLLGIPAIS IAGLVELKSA LSTSAGAGPL PLLVGIFSAA VVSWLAIDWL 250
    LRFLQRNSTW IFVGYRLVFG AGLLVWWAFK SAN 283
    Length:283
    Mass (Da):29,891
    Last modified:November 22, 2005 - v1
    Checksum:i287B341DB6592274
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000097 Genomic DNA. Translation: ABB25330.1.
    RefSeqiWP_011359187.1. NC_007513.1.
    YP_376374.1. NC_007513.1.

    Genome annotation databases

    EnsemblBacteriaiABB25330; ABB25330; Syncc9902_0358.
    GeneIDi3743572.
    KEGGisye:Syncc9902_0358.
    PATRICi23797791. VBISynSp76179_0369.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000097 Genomic DNA. Translation: ABB25330.1 .
    RefSeqi WP_011359187.1. NC_007513.1.
    YP_376374.1. NC_007513.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 316279.Syncc9902_0358.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB25330 ; ABB25330 ; Syncc9902_0358 .
    GeneIDi 3743572.
    KEGGi sye:Syncc9902_0358.
    PATRICi 23797791. VBISynSp76179_0369.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi FNDAHAK.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci SSP316279:GJCI-363-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Synechococcus sp. CC9902."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CC9902.

    Entry informationi

    Entry nameiUPPP_SYNS9
    AccessioniPrimary (citable) accession number: Q3AZZ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3