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Protein

Ribonuclease Z

Gene

rnz

Organism
Synechococcus sp. (strain CC9902)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi62Zinc 1; catalyticUniRule annotation1
Metal bindingi64Zinc 1; catalyticUniRule annotation1
Active sitei66Proton acceptorUniRule annotation1
Metal bindingi66Zinc 2; catalyticUniRule annotation1
Metal bindingi67Zinc 2; catalyticUniRule annotation1
Metal bindingi145Zinc 1; catalyticUniRule annotation1
Metal bindingi216Zinc 1; catalyticUniRule annotation1
Metal bindingi216Zinc 2; catalyticUniRule annotation1
Metal bindingi274Zinc 2; catalyticUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processtRNA processing
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease ZUniRule annotation (EC:3.1.26.11UniRule annotation)
Short name:
RNase ZUniRule annotation
Alternative name(s):
tRNA 3 endonucleaseUniRule annotation
tRNase ZUniRule annotation
Gene namesi
Name:rnzUniRule annotation
Ordered Locus Names:Syncc9902_0532
OrganismiSynechococcus sp. (strain CC9902)
Taxonomic identifieri316279 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000002712 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000703471 – 319Ribonuclease ZAdd BLAST319

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi316279.Syncc9902_0532.

Structurei

3D structure databases

ProteinModelPortaliQ3AZH7.
SMRiQ3AZH7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase Z family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105IES. Bacteria.
COG1234. LUCA.
HOGENOMiHOG000272419.
KOiK00784.
OMAiGTQRQMM.
OrthoDBiPOG091H07TH.

Family and domain databases

CDDicd07717. RNaseZ_ZiPD-like_MBL-fold. 1 hit.
Gene3Di3.60.15.10. 1 hit.
HAMAPiMF_01818. RNase_Z_BN. 1 hit.
InterProiView protein in InterPro
IPR001279. Metallo-B-lactamas.
IPR036866. Metallo-hydrolase/OxRdtase.
IPR013471. RNase_Z/BN.
PfamiView protein in Pfam
PF12706. Lactamase_B_2. 1 hit.
SUPFAMiSSF56281. SSF56281. 1 hit.
TIGRFAMsiTIGR02651. RNase_Z. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3AZH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVTFLGTSS GVPTRARNVS AVALRLPQRS EMWLFDCGEG TQHQFLRSEL
60 70 80 90 100
RLSQLRRVFV THMHGDHVFG LPGLLASLGL AGNSNEGVDL YGPDPLESYL
110 120 130 140 150
NGVLRTSSTR IGYPLKVHRV HDCAENGTLV YEDDDLMVRC TPLTHRVPAY
160 170 180 190 200
AYRVDQKPLA GRFDIAKAKD LQIPPGPIYA QLKRGDTVTL EDGRVIDGTT
210 220 230 240 250
LCGPERPGVS VVYCTDTVFC EAAVDLAQGA DLLIHESTFA HQESEMAYQK
260 270 280 290 300
QHSTSTMAAQ TAAEANVGQL VLTHLSPRYA PGNAVTPEDL LKEAQAIFPN
310
TCLAKDFLTL EVKPRCNSL
Length:319
Mass (Da):34,905
Last modified:November 22, 2005 - v1
Checksum:iE0CFE01E92EC3ADA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000097 Genomic DNA. Translation: ABB25500.1.
RefSeqiWP_011359347.1. NC_007513.1.

Genome annotation databases

EnsemblBacteriaiABB25500; ABB25500; Syncc9902_0532.
KEGGisye:Syncc9902_0532.

Similar proteinsi

Entry informationi

Entry nameiRNZ_SYNS9
AccessioniPrimary (citable) accession number: Q3AZH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 22, 2005
Last modified: October 25, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families