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Q3AZD9

- PYRF_SYNS9

UniProt

Q3AZD9 - PYRF_SYNS9

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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Synechococcus sp. (strain CC9902)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei18 – 181SubstrateUniRule annotation
Binding sitei39 – 391SubstrateUniRule annotation
Active sitei68 – 681Proton donorUniRule annotation
Binding sitei130 – 1301SubstrateUniRule annotation
Binding sitei192 – 1921SubstrateUniRule annotation
Binding sitei201 – 2011SubstrateUniRule annotation
Binding sitei221 – 2211Substrate; via amide nitrogenUniRule annotation
Binding sitei222 – 2221SubstrateUniRule annotation

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciSSP316279:GJCI-578-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
Ordered Locus Names:Syncc9902_0570
OrganismiSynechococcus sp. (strain CC9902)
Taxonomic identifieri316279 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000002712: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 243243Orotidine 5'-phosphate decarboxylasePRO_0000241918Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi316279.Syncc9902_0570.

Structurei

3D structure databases

ProteinModelPortaliQ3AZD9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni66 – 7510Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000226070.
KOiK01591.
OrthoDBiEOG6N6815.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_B. OMPdecase_type1_B.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3AZD9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALLHSANPA DQIIVALDGM APDQALAFSV QVEGLRWVKV GLELFVQAGP
60 70 80 90 100
EVVAQLREQD LRVFLDLKFH DIPATMAGAC RRAAALGAEL ITVHACAGSE
110 120 130 140 150
ALNAAQSAAM EGAQSSGQPS PTLLAVTVLT SWEEQRLQRE LAISQGIAPR
160 170 180 190 200
VSALAQLSAT AGIGGCVCSP WEAAALRAQH PEPFALITPG IRLKGAAVGD
210 220 230 240
QARVMGPAEA MTAGATQLVI GRPITRANDP SAAFNACCRE LRT
Length:243
Mass (Da):25,277
Last modified:June 27, 2006 - v2
Checksum:i3A4AE1A94CBF1FA7
GO

Sequence cautioni

The sequence ABB25538.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000097 Genomic DNA. Translation: ABB25538.1. Different initiation.
RefSeqiWP_011359384.1. NC_007513.1.
YP_376582.1. NC_007513.1.

Genome annotation databases

EnsemblBacteriaiABB25538; ABB25538; Syncc9902_0570.
GeneIDi3742897.
KEGGisye:Syncc9902_0570.
PATRICi23798305. VBISynSp76179_0619.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000097 Genomic DNA. Translation: ABB25538.1 . Different initiation.
RefSeqi WP_011359384.1. NC_007513.1.
YP_376582.1. NC_007513.1.

3D structure databases

ProteinModelPortali Q3AZD9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316279.Syncc9902_0570.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB25538 ; ABB25538 ; Syncc9902_0570 .
GeneIDi 3742897.
KEGGi sye:Syncc9902_0570.
PATRICi 23798305. VBISynSp76179_0619.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000226070.
KOi K01591.
OrthoDBi EOG6N6815.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci SSP316279:GJCI-578-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01200_B. OMPdecase_type1_B.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Synechococcus sp. CC9902."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CC9902.

Entry informationi

Entry nameiPYRF_SYNS9
AccessioniPrimary (citable) accession number: Q3AZD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: October 1, 2014
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3