Q3AYS2 (LPXD_SYNS9) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UDP-3-O-acylglucosamine N-acyltransferase
EC=2.3.1.-

Gene names

Name:	lpxD
Ordered Locus Names:	Syncc9902_0787

Organism

Synechococcus sp. (strain CC9902) [Complete proteome] [HAMAP]

Taxonomic identifier

316279 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	347 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00523
Catalytic activity	(3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D-glucosamine + [acyl-carrier-protein]. HAMAP MF_00523
Pathway	Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. HAMAP MF_00523
Subunit structure	Homotrimer By similarity. HAMAP MF_00523
Sequence similarities	Belongs to the transferase hexapeptide repeat family. LpxD subfamily.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Domain	Repeat
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	transferase activity, transferring acyl groups other than amino-acyl groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 347	347	UDP-3-O-acylglucosamine N-acyltransferase HAMAP MF_00523		PRO_0000264444
Sites
	Active site	248	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3AYS2 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 55B96AE725DB9AFC	FASTA	347	35,856
	10 20 30 40 50 60 MRFSTLLKDL QTGEAELRWS QCGADPILAG AASLEQAKGD QLSFLEKGNA LIAALTETGA 70 80 90 100 110 120 GALLLPDQPD LIQCASERGI AFAVLANPRL AFAEALERLH PRLRPLAEIH PSAVVDERAV 130 140 150 160 170 180 VGPGTFIAPR VCIGASSRIG ANCIVHPGVV IYDDVEVGEG CELHANAVLH PGSRLGRGCV 190 200 210 220 230 240 VNSNAVIGSE GFGFVPTPRG WRKMPQTGQV VLEDGVEVGC GSTIDRPSVG ETRIGAGSKI 250 260 270 280 290 300 DNLVQIGHGV TTGRGCALAS QVGIAGGAKL GHGVILAGQV GVANRAVVGD GAIASSKSGI 310 320 330 340 HGEVAPGEVV SGYPAIPNRL WLRCSAAFSK LPEMAKTLRE LKRDISQ

References

[1]

"Complete sequence of Synechococcus sp. CC9902." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CC9902.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000097 Genomic DNA. Translation: ABB25755.1.
RefSeq	YP_376799.1. NC_007513.1.
3D structure databases
ProteinModelPortal	Q3AYS2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3AYS2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3743894.
GenomeReviews	Gene locus Syncc9902_0787 in contig CP000097_GR.
KEGG	sye:Syncc9902_0787.
PATRIC	23798795. VBISynSp76179_0861.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1044.
HOGENOM	HBG469615.
OMA	SYPAKIM.
PhylomeDB	Q3AYS2.
ProtClustDB	PRK00892.
Enzyme and pathway databases
BioCyc	SSP1131-1:SYNCC9902_0787-MONOMER.
Family and domain databases
HAMAP	MF_00523. LpxD. [Tree]
InterPro	IPR001451. Hexapep_transf. IPR011004. Trimer_LpxA-like. IPR007691. UDP-3-O_GlcNAc_AcTrfase. IPR020573. UDP_GlcNAc_AcTrfase_non-rep. [Graphical view]
KO	K02536.
Pfam	PF00132. Hexapep. 5 hits. PF04613. LpxD. 1 hit. [Graphical view]
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMs	TIGR01853. Lipid_A_lpxD. 1 hit.
PROSITE	PS00101. HEXAPEP_TRANSFERASES. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LPXD_SYNS9

Accession

Primary (citable) accession number: Q3AYS2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	November 22, 2005
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program