Q3AYN5 (DAPB_SYNS9) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dihydrodipicolinate reductase
Short name=DHPR
EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	Syncc9902_0826

Organism

Synechococcus sp. (strain CC9902) [Complete proteome] [HAMAP]

Taxonomic identifier

316279 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ = (S)-2,3-dihydrodipicolinate + NAD(P)H. HAMAP MF_00102
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP MF_00102
Subcellular location	Cytoplasm By similarity HAMAP MF_00102.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADPH binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 277	277	Dihydrodipicolinate reductase HAMAP MF_00102		PRO_1000008655

Sequences

	Sequence		Length	Mass (Da)
	Q3AYN5 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: C6BD41A9CD83CDF2	FASTA	277	29,348
	10 20 30 40 50 60 MSSPIPVVVA GALGRMGAEV INAVVNAEDC QLVGAIDNTP GKEGTDVGLE LGIKELEVAV 70 80 90 100 110 120 TADFEGCLCA VSQSVRNSDQ NAVLVDFTHP SVVFDHTRAA IAYGVHPVIG TTGLSPIQLN 130 140 150 160 170 180 DLTEFSAKAS IGGAVIPNFS VGMVLLQQAA AAAARFYDHA ELTELHHNRK ADAPSGTCIK 190 200 210 220 230 240 TAELMEEVKQ SFNPAEVDEH ESLQGSRGGV RDSGLNLHSL RLPGLVAHQE VMFGAPGETY 250 260 270 TLRHDTIDRS AYMPGVLLTI RKVGSLQQLV YGLERLI

References

[1]

"Complete sequence of Synechococcus sp. CC9902." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CC9902.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000097 Genomic DNA. Translation: ABB25792.1.
RefSeq	YP_376836.1. NC_007513.1.
3D structure databases
HSSP	HSSP built from PDB template 1YL7 based on UniProtKB P72024.
ProteinModelPortal	Q3AYN5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3AYN5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3743605.
GenomeReviews	Gene locus Syncc9902_0826 in contig CP000097_GR.
KEGG	sye:Syncc9902_0826.
PATRIC	23798879. VBISynSp76179_0903.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0289.
HOGENOM	HBG594002.
OMA	DRASFMP.
PhylomeDB	Q3AYN5.
ProtClustDB	PRK00048.
Enzyme and pathway databases
BioCyc	SSP1131-1:SYNCC9902_0826-MONOMER.
Family and domain databases
HAMAP	MF_00102. DapB. [Tree]
InterPro	IPR022663. DapB_C. IPR000846. DapB_N. IPR022664. DapB_N_CS. IPR011770. Dihydrodipicolinate_Rdtase. IPR023940. Dihydrodipicolinate_Rdtase_bac. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 2 hits.
KO	K00215.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
PIRSF	PIRSF000161. DHPR. 1 hit.
TIGRFAMs	TIGR00036. DapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_SYNS9

Accession

Primary (citable) accession number: Q3AYN5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 22, 2005
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program