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Q3AYI2 (GLO2_SYNS9) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Hydroxyacylglutathione hydrolase
EC=3.1.2.6
Alternative name(s):
Glyoxalase II
Short name=Glx II
Gene names
Name:gloB
Ordered Locus Names:Syncc9902_0879
OrganismSynechococcus sp. (strain CC9902) [Complete proteome] [HAMAP]
Taxonomic identifier316279 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length251 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid By similarity. HAMAP MF_01374

Catalytic activity

S-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate. HAMAP MF_01374

Cofactor

Binds 2 zinc ions per subunit By similarity. HAMAP MF_01374

Pathway

Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2. HAMAP MF_01374

Subunit structure

Monomer By similarity. HAMAP MF_01374

Sequence similarities

Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

Ontologies

Keywords
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionhydroxyacylglutathione hydrolase activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 251251Hydroxyacylglutathione hydrolase HAMAP MF_01374
PRO_0000309715

Sites

Metal binding541Zinc 1 By similarity
Metal binding561Zinc 1 By similarity
Metal binding581Zinc 2 By similarity
Metal binding591Zinc 2 By similarity
Metal binding1131Zinc 1 By similarity
Metal binding1401Zinc 1 By similarity
Metal binding1401Zinc 2 By similarity
Metal binding1781Zinc 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3AYI2 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: 885A83C38A903D0A

FASTA25127,882
        10         20         30         40         50         60 
MHSTLHALPV LQDNVIWIWA RGKNAVVVDP AVAEPVNQWL NAHGMCLRAI LQTHHHADHI 

        70         80         90        100        110        120 
GGTPDLLREW PQAEVVAATA DRLRIPLQTR GVADGDVINL LGRRLEVIDV AAHTSAHIAF 

       130        140        150        160        170        180 
IIRNDDDQDP SFGPLAFCGD TLFAGGCGRL FEGSAQDMYR ALQRFAALPD ETLVCCAHEY 

       190        200        210        220        230        240 
TEANLRWATE QRPNDVQITT RHQTVKALRS RGDLSLPSSI GAEKRTNLFM QAETAEQLAE 

       250 
LRSHKDHWRS S

« Hide

References

[1]"Complete sequence of Synechococcus sp. CC9902."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CC9902.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000097 Genomic DNA. Translation: ABB25845.1.
RefSeqYP_376889.1. NC_007513.1.

3D structure databases

ProteinModelPortalQ3AYI2.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3AYI2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3742332.
GenomeReviewsGene locus Syncc9902_0879 in contig CP000097_GR.
KEGGsye:Syncc9902_0879.
PATRIC23799005. VBISynSp76179_0965.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0491.
HOGENOMHBG753931.
OMAFLCRTDN.
PhylomeDBQ3AYI2.
ProtClustDBCLSK647525.

Enzyme and pathway databases

BioCycSSP1131-1:SYNCC9902_0879-MONOMER.

Family and domain databases

HAMAPMF_01374. Glyoxalase_2.
[Tree]
InterProIPR001279. Beta-lactamas-like.
IPR017782. Hydroxyacylglutathione_Hdrlase.
[Graphical view]
KOK01069.
PANTHERPTHR11935:SF7. PTHR11935:SF7. 1 hit.
PfamPF00753. Lactamase_B. 1 hit.
[Graphical view]
SMARTSM00849. Lactamase_B. 1 hit.
[Graphical view]
TIGRFAMsTIGR03413. GSH_gloB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGLO2_SYNS9
AccessionPrimary (citable) accession number: Q3AYI2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 22, 2005
Last modified: January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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