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Q3AYG9

- PYRC_SYNS9

UniProt

Q3AYG9 - PYRC_SYNS9

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Protein
Dihydroorotase
Gene
pyrC, Syncc9902_0892
Organism
Synechococcus sp. (strain CC9902)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate.UniRule annotation

Cofactori

Binds 2 zinc ions per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi14 – 141Zinc 1; via tele nitrogen By similarity
Metal bindingi16 – 161Zinc 1; via tele nitrogen By similarity
Metal bindingi100 – 1001Zinc 1; via carbamate group By similarity
Metal bindingi100 – 1001Zinc 2; via carbamate group By similarity
Metal bindingi137 – 1371Zinc 2; via pros nitrogen By similarity
Metal bindingi175 – 1751Zinc 2; via tele nitrogen By similarity
Metal bindingi248 – 2481Zinc 1 By similarity

GO - Molecular functioni

  1. dihydroorotase activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Pyrimidine biosynthesis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSSP316279:GJCI-903-MONOMER.
UniPathwayiUPA00070; UER00117.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroorotase (EC:3.5.2.3)
Short name:
DHOase
Gene namesi
Name:pyrC
Ordered Locus Names:Syncc9902_0892
OrganismiSynechococcus sp. (strain CC9902)
Taxonomic identifieri316279 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000002712: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343DihydroorotaseUniRule annotation
PRO_1000024069Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei100 – 1001N6-carboxylysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi316279.Syncc9902_0892.

Structurei

3D structure databases

ProteinModelPortaliQ3AYG9.
SMRiQ3AYG9. Positions 2-340.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0418.
HOGENOMiHOG000256259.
KOiK01465.
OMAiLKRNVHQ.
OrthoDBiEOG6TFCMH.

Family and domain databases

HAMAPiMF_00219. PyrC_type1.
InterProiIPR006680. Amidohydro_1.
IPR004721. DHOdimr.
IPR002195. Dihydroorotase_CS.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
[Graphical view]
PIRSFiPIRSF001237. DHOdimr. 1 hit.
TIGRFAMsiTIGR00856. pyrC_dimer. 1 hit.
PROSITEiPS00482. DIHYDROOROTASE_1. 1 hit.
PS00483. DIHYDROOROTASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3AYG9-1 [UniParc]FASTAAdd to Basket

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MSDQIQLIAP DDWHVHLRDG EMLKQVVPYT AQMFRRAIVM PNLRPPVVTV    50
EAAKAYRDQI VAACHPNWGF TPLMTAYLTD DIAPEEIERG FHEGVFTAAK 100
LYPANATTNS AAGVTELRHI HGVLLVMERI GMPLLIHGEV TDVDVDVFDR 150
EAVFIERSLK PIRDRYPGLK VVLEHITTEQ AVDFVGSADQ NLAATITPHH 200
LHINRNAMFA GGLRSDFYCL PVAKRERHRL ALRRAAMSGD RRFFLGTDSA 250
PHARPGKESS CGCAGIFNAP HALESYAMAF AQDDKLDKLE AFASLHGPAF 300
YGLPVNEGIV TLQRDDKLVP NVVNGLVPFH AGETLPWRLQ PCT 343
Length:343
Mass (Da):38,057
Last modified:November 22, 2005 - v1
Checksum:i8479D756696FD2CE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000097 Genomic DNA. Translation: ABB25858.1.
RefSeqiWP_011359695.1. NC_007513.1.
YP_376902.1. NC_007513.1.

Genome annotation databases

EnsemblBacteriaiABB25858; ABB25858; Syncc9902_0892.
GeneIDi3743497.
KEGGisye:Syncc9902_0892.
PATRICi23799033. VBISynSp76179_0979.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000097 Genomic DNA. Translation: ABB25858.1 .
RefSeqi WP_011359695.1. NC_007513.1.
YP_376902.1. NC_007513.1.

3D structure databases

ProteinModelPortali Q3AYG9.
SMRi Q3AYG9. Positions 2-340.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316279.Syncc9902_0892.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB25858 ; ABB25858 ; Syncc9902_0892 .
GeneIDi 3743497.
KEGGi sye:Syncc9902_0892.
PATRICi 23799033. VBISynSp76179_0979.

Phylogenomic databases

eggNOGi COG0418.
HOGENOMi HOG000256259.
KOi K01465.
OMAi LKRNVHQ.
OrthoDBi EOG6TFCMH.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00117 .
BioCyci SSP316279:GJCI-903-MONOMER.

Family and domain databases

HAMAPi MF_00219. PyrC_type1.
InterProi IPR006680. Amidohydro_1.
IPR004721. DHOdimr.
IPR002195. Dihydroorotase_CS.
[Graphical view ]
Pfami PF01979. Amidohydro_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF001237. DHOdimr. 1 hit.
TIGRFAMsi TIGR00856. pyrC_dimer. 1 hit.
PROSITEi PS00482. DIHYDROOROTASE_1. 1 hit.
PS00483. DIHYDROOROTASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Synechococcus sp. CC9902."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CC9902.

Entry informationi

Entry nameiPYRC_SYNS9
AccessioniPrimary (citable) accession number: Q3AYG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 22, 2005
Last modified: September 3, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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