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Q3AXV7

- SYL_SYNS9

UniProt

Q3AXV7 - SYL_SYNS9

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Synechococcus sp. (strain CC9902)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei646 – 6461ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSSP316279:GJCI-1117-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Syncc9902_1106
    OrganismiSynechococcus sp. (strain CC9902)
    Taxonomic identifieri316279 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000002712: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 884884Leucine--tRNA ligasePRO_0000334830Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi316279.Syncc9902_1106.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3AXV7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi69 – 7911"HIGH" regionAdd
    BLAST
    Motifi643 – 6475"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3AXV7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYGTIAAKPH AGPVNAASSS ASANNSPQEN RYDPSALEQR WRARWKDQGL    50
    DTTETESSKP GFFALSMFPY PSGSLHMGHV RNYVITDVIA RVQRMRGDSV 100
    LHPMGWDAFG LPAENAAIER NIDPGEWTDR NIDQMRNQLD RLGLSIDWDR 150
    EQATCHSDYY RWTQWLFLEL LEGGLAYRKN ATVNWDPVDQ TVLANEQVDA 200
    DGRSWRSGAL VEQRQLNQWF LRITDYAEAL LNDLDKLKGW PERVRTMQAN 250
    WIGRSEGAEI TFQVTGSSQQ SITVFTTRPD TLSGASYVVL APEHQLVDGL 300
    TTEEHLASVD QFRKQVARLS TIERTSDERP KQGVATGACV TNPLTGEQLP 350
    VWIADYVLAD YGTGAVMGVP AHDQRDIQFA KANALPIRQV IDAEGAKEAI 400
    DAGKAWTEAG TLINSGVFDG QPSNQGKGSI TSHGETAGWA TSKVTYRLRD 450
    WLISRQRYWG CPIPVIHCPT CGVVPVPRDD LPVELPRGID LSGKGGSPLS 500
    QQSDWVNVSC PCCGGAAKRE TDTMDTFMCS SWYFLRFADP HNTDQPFSKE 550
    AVRRWLPVKQ YVGGIEHAIL HLLYSRFFTK ALRDRGLIDI DEPFERLLTQ 600
    GMVQAITYRN PITGKYIATA DVSDPNDPLD PTTGDKLEVL FEKMSKSKYN 650
    GVDPAAVIDR YGADTARMFI LFKAPPEKDL EWDDADVEGQ FRFLQRLWRL 700
    VENASSTLTD LNSTGCPADL TDQEADVRRA LHLAIDAVSD DLNGEIQLNT 750
    AISELMKLSN TITSSGPDRL RPPILQEALS GLIRLLAPFA PHIAEEFWSR 800
    LGGDGSVHQQ SWPSVDPSAL IQDTISIVIQ VKGKVRGSIQ APADADKATL 850
    ESMALSSDVA NKWLEGATPK RVIVVPGKLV NLVP 884
    Length:884
    Mass (Da):97,885
    Last modified:November 22, 2005 - v1
    Checksum:i09C2423CAC7AAB09
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000097 Genomic DNA. Translation: ABB26070.1.
    RefSeqiWP_011359900.1. NC_007513.1.
    YP_377114.1. NC_007513.1.

    Genome annotation databases

    EnsemblBacteriaiABB26070; ABB26070; Syncc9902_1106.
    GeneIDi3743320.
    KEGGisye:Syncc9902_1106.
    PATRICi23799531. VBISynSp76179_1227.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000097 Genomic DNA. Translation: ABB26070.1 .
    RefSeqi WP_011359900.1. NC_007513.1.
    YP_377114.1. NC_007513.1.

    3D structure databases

    ProteinModelPortali Q3AXV7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 316279.Syncc9902_1106.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB26070 ; ABB26070 ; Syncc9902_1106 .
    GeneIDi 3743320.
    KEGGi sye:Syncc9902_1106.
    PATRICi 23799531. VBISynSp76179_1227.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci SSP316279:GJCI-1117-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Synechococcus sp. CC9902."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CC9902.

    Entry informationi

    Entry nameiSYL_SYNS9
    AccessioniPrimary (citable) accession number: Q3AXV7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3