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Q3AXV7

- SYL_SYNS9

UniProt

Q3AXV7 - SYL_SYNS9

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Synechococcus sp. (strain CC9902)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei646 – 6461ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSP316279:GJCI-1117-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Syncc9902_1106
OrganismiSynechococcus sp. (strain CC9902)
Taxonomic identifieri316279 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000002712: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 884884Leucine--tRNA ligasePRO_0000334830Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi316279.Syncc9902_1106.

Structurei

3D structure databases

ProteinModelPortaliQ3AXV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi69 – 7911"HIGH" regionAdd
BLAST
Motifi643 – 6475"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3AXV7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYGTIAAKPH AGPVNAASSS ASANNSPQEN RYDPSALEQR WRARWKDQGL
60 70 80 90 100
DTTETESSKP GFFALSMFPY PSGSLHMGHV RNYVITDVIA RVQRMRGDSV
110 120 130 140 150
LHPMGWDAFG LPAENAAIER NIDPGEWTDR NIDQMRNQLD RLGLSIDWDR
160 170 180 190 200
EQATCHSDYY RWTQWLFLEL LEGGLAYRKN ATVNWDPVDQ TVLANEQVDA
210 220 230 240 250
DGRSWRSGAL VEQRQLNQWF LRITDYAEAL LNDLDKLKGW PERVRTMQAN
260 270 280 290 300
WIGRSEGAEI TFQVTGSSQQ SITVFTTRPD TLSGASYVVL APEHQLVDGL
310 320 330 340 350
TTEEHLASVD QFRKQVARLS TIERTSDERP KQGVATGACV TNPLTGEQLP
360 370 380 390 400
VWIADYVLAD YGTGAVMGVP AHDQRDIQFA KANALPIRQV IDAEGAKEAI
410 420 430 440 450
DAGKAWTEAG TLINSGVFDG QPSNQGKGSI TSHGETAGWA TSKVTYRLRD
460 470 480 490 500
WLISRQRYWG CPIPVIHCPT CGVVPVPRDD LPVELPRGID LSGKGGSPLS
510 520 530 540 550
QQSDWVNVSC PCCGGAAKRE TDTMDTFMCS SWYFLRFADP HNTDQPFSKE
560 570 580 590 600
AVRRWLPVKQ YVGGIEHAIL HLLYSRFFTK ALRDRGLIDI DEPFERLLTQ
610 620 630 640 650
GMVQAITYRN PITGKYIATA DVSDPNDPLD PTTGDKLEVL FEKMSKSKYN
660 670 680 690 700
GVDPAAVIDR YGADTARMFI LFKAPPEKDL EWDDADVEGQ FRFLQRLWRL
710 720 730 740 750
VENASSTLTD LNSTGCPADL TDQEADVRRA LHLAIDAVSD DLNGEIQLNT
760 770 780 790 800
AISELMKLSN TITSSGPDRL RPPILQEALS GLIRLLAPFA PHIAEEFWSR
810 820 830 840 850
LGGDGSVHQQ SWPSVDPSAL IQDTISIVIQ VKGKVRGSIQ APADADKATL
860 870 880
ESMALSSDVA NKWLEGATPK RVIVVPGKLV NLVP
Length:884
Mass (Da):97,885
Last modified:November 22, 2005 - v1
Checksum:i09C2423CAC7AAB09
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000097 Genomic DNA. Translation: ABB26070.1.
RefSeqiWP_011359900.1. NC_007513.1.
YP_377114.1. NC_007513.1.

Genome annotation databases

EnsemblBacteriaiABB26070; ABB26070; Syncc9902_1106.
GeneIDi3743320.
KEGGisye:Syncc9902_1106.
PATRICi23799531. VBISynSp76179_1227.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000097 Genomic DNA. Translation: ABB26070.1 .
RefSeqi WP_011359900.1. NC_007513.1.
YP_377114.1. NC_007513.1.

3D structure databases

ProteinModelPortali Q3AXV7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316279.Syncc9902_1106.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB26070 ; ABB26070 ; Syncc9902_1106 .
GeneIDi 3743320.
KEGGi sye:Syncc9902_1106.
PATRICi 23799531. VBISynSp76179_1227.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SSP316279:GJCI-1117-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Synechococcus sp. CC9902."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CC9902.

Entry informationi

Entry nameiSYL_SYNS9
AccessioniPrimary (citable) accession number: Q3AXV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 22, 2005
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3