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Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

trmFO

Organism
Synechococcus sp. (strain CC9902)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotation

Cofactori

FADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 206FADUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciSSP316279:GJCI-1439-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
Gene namesi
Name:trmFOUniRule annotation
Ordered Locus Names:Syncc9902_1425
OrganismiSynechococcus sp. (strain CC9902)
Taxonomic identifieri316279 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
Proteomesi
  • UP000002712 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 460460Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOPRO_0000346407Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi316279.Syncc9902_1425.

Structurei

3D structure databases

ProteinModelPortaliQ3AX63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QXI. Bacteria.
COG1206. LUCA.
HOGENOMiHOG000252054.
OMAiDYLNCPM.
OrthoDBiPOG091H00B3.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_01037. TrmFO. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR002218. MnmG-rel.
IPR004417. TrmFO.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3AX63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNDRSVKRS VTVLGAGLAG TEAAWQVACA GIPVTLVEMR PVRRSPAHHS
60 70 80 90 100
SDFAELVCSN SFGALSSDRA AGLLQEELRR LGSLVIRTAD DHAVPAGGAL
110 120 130 140 150
AVDRGRYSAA LTEILDQHPL VTIERREQMD LPEVDAVTVL ATGPLTSESL
160 170 180 190 200
ANDLRGFTGR DDCHFFDAAS PIVHGDSIDL NLAFRASRYD KGDADYINCP
210 220 230 240 250
MNKAEFLAFR EALLEAEQAE LKDFDQESAK FFEGCLPIEE LARRGEDTMR
260 270 280 290 300
YGPLKPIGLW DPRWGDVNDR DVRRAKRAYA VVQLRQEDKD GRLWNLVGFQ
310 320 330 340 350
TNLKWGEQRR VLQMIPGLAQ AEFVRFGVMH RNTFLESPQL LDPTLQFRTR
360 370 380 390 400
RHLLAAGQIT GTEGYAAAVA GGWLAGTNAA RLVRGLDPIA LPNTTMAGAL
410 420 430 440 450
THFVSEAPTK KFQPMPPNFG LLPDLPERIR DKRARYGAYR DRSLADLEPI
460
RALIPEPLLA
Length:460
Mass (Da):50,801
Last modified:November 22, 2005 - v1
Checksum:iF06E7DAA545C2BCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000097 Genomic DNA. Translation: ABB26389.1.
RefSeqiWP_011360211.1. NC_007513.1.

Genome annotation databases

EnsemblBacteriaiABB26389; ABB26389; Syncc9902_1425.
KEGGisye:Syncc9902_1425.
PATRICi23800239. VBISynSp76179_1579.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000097 Genomic DNA. Translation: ABB26389.1.
RefSeqiWP_011360211.1. NC_007513.1.

3D structure databases

ProteinModelPortaliQ3AX63.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi316279.Syncc9902_1425.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB26389; ABB26389; Syncc9902_1425.
KEGGisye:Syncc9902_1425.
PATRICi23800239. VBISynSp76179_1579.

Phylogenomic databases

eggNOGiENOG4107QXI. Bacteria.
COG1206. LUCA.
HOGENOMiHOG000252054.
OMAiDYLNCPM.
OrthoDBiPOG091H00B3.

Enzyme and pathway databases

BioCyciSSP316279:GJCI-1439-MONOMER.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_01037. TrmFO. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR002218. MnmG-rel.
IPR004417. TrmFO.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRMFO_SYNS9
AccessioniPrimary (citable) accession number: Q3AX63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: November 22, 2005
Last modified: September 7, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.