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Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

trmFO

Organism
Synechococcus sp. (strain CC9902)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotation

Cofactori

FADUniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 20FADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyciSSP316279:G1G4V-1467-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
Gene namesi
Name:trmFOUniRule annotation
Ordered Locus Names:Syncc9902_1425
OrganismiSynechococcus sp. (strain CC9902)
Taxonomic identifieri316279 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000002712 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003464071 – 460Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOAdd BLAST460

Interactioni

Protein-protein interaction databases

STRINGi316279.Syncc9902_1425

Structurei

3D structure databases

ProteinModelPortaliQ3AX63
SMRiQ3AX63
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QXI Bacteria
COG1206 LUCA
HOGENOMiHOG000252054
KOiK04094
OMAiRFGPMKP
OrthoDBiPOG091H00B3

Family and domain databases

Gene3Di3.50.50.60, 2 hits
HAMAPiMF_01037 TrmFO, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR002218 MnmG-rel
IPR004417 TrmFO
PANTHERiPTHR11806 PTHR11806, 1 hit
PTHR11806:SF2 PTHR11806:SF2, 1 hit
PfamiView protein in Pfam
PF01134 GIDA, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
TIGRFAMsiTIGR00137 gid_trmFO, 1 hit

Sequencei

Sequence statusi: Complete.

Q3AX63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNDRSVKRS VTVLGAGLAG TEAAWQVACA GIPVTLVEMR PVRRSPAHHS
60 70 80 90 100
SDFAELVCSN SFGALSSDRA AGLLQEELRR LGSLVIRTAD DHAVPAGGAL
110 120 130 140 150
AVDRGRYSAA LTEILDQHPL VTIERREQMD LPEVDAVTVL ATGPLTSESL
160 170 180 190 200
ANDLRGFTGR DDCHFFDAAS PIVHGDSIDL NLAFRASRYD KGDADYINCP
210 220 230 240 250
MNKAEFLAFR EALLEAEQAE LKDFDQESAK FFEGCLPIEE LARRGEDTMR
260 270 280 290 300
YGPLKPIGLW DPRWGDVNDR DVRRAKRAYA VVQLRQEDKD GRLWNLVGFQ
310 320 330 340 350
TNLKWGEQRR VLQMIPGLAQ AEFVRFGVMH RNTFLESPQL LDPTLQFRTR
360 370 380 390 400
RHLLAAGQIT GTEGYAAAVA GGWLAGTNAA RLVRGLDPIA LPNTTMAGAL
410 420 430 440 450
THFVSEAPTK KFQPMPPNFG LLPDLPERIR DKRARYGAYR DRSLADLEPI
460
RALIPEPLLA
Length:460
Mass (Da):50,801
Last modified:November 22, 2005 - v1
Checksum:iF06E7DAA545C2BCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000097 Genomic DNA Translation: ABB26389.1
RefSeqiWP_011360211.1, NC_007513.1

Genome annotation databases

EnsemblBacteriaiABB26389; ABB26389; Syncc9902_1425
KEGGisye:Syncc9902_1425

Similar proteinsi

Entry informationi

Entry nameiTRMFO_SYNS9
AccessioniPrimary (citable) accession number: Q3AX63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: November 22, 2005
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health