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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Synechococcus sp. (strain CC9902)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei35S-adenosyl-L-methionineUniRule annotation1
Binding sitei60S-adenosyl-L-methionineUniRule annotation1
Binding sitei87S-adenosyl-L-methionineUniRule annotation1
Active sitei113By similarity1
Binding sitei113S-adenosyl-L-methionineUniRule annotation1
Binding sitei117SubstrateUniRule annotation1
Binding sitei149SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciSSP316279:G1G4V-2136-MONOMER
UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:Syncc9902_2064
OrganismiSynechococcus sp. (strain CC9902)
Taxonomic identifieri316279 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000002712 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002882441 – 236tRNA (guanine-N(7)-)-methyltransferaseAdd BLAST236

Interactioni

Protein-protein interaction databases

STRINGi316279.Syncc9902_2064

Structurei

3D structure databases

ProteinModelPortaliQ3AW35
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107YD0 Bacteria
COG0220 LUCA
HOGENOMiHOG000237936
KOiK03439
OMAiQFPDPWF
OrthoDBiPOG091H015P

Family and domain databases

HAMAPiMF_01057 tRNA_methyltr_TrmB, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00091 TIGR00091, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

Q3AW35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQHVNPLSR SFQLPLRLPP PSELFTHPEH PIHLDIGCAR GRCILDLADR
60 70 80 90 100
HPNWNHIGVE IRRPLVIPAD REALESPHGN VRVLFCNANI SLEGWMETLP
110 120 130 140 150
KDRLQRVSIQ FPDPWFKRRH RKRRVLQPRL LMAIASALQP GKDFFIQSDV
160 170 180 190 200
REVIDPMVAL TELSGCFDRP ENDAHPWRRT NPLTVPTERE RYVMDQQLPV
210 220 230
YRVLFRRNHT HQPPIEEFEQ HWQEIDNPGN APTPDA
Length:236
Mass (Da):27,647
Last modified:November 22, 2005 - v1
Checksum:i2BBBE85EE3C3BDE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000097 Genomic DNA Translation: ABB27022.1
RefSeqiWP_011360809.1, NC_007513.1

Genome annotation databases

EnsemblBacteriaiABB27022; ABB27022; Syncc9902_2064
KEGGisye:Syncc9902_2064

Similar proteinsi

Entry informationi

Entry nameiTRMB_SYNS9
AccessioniPrimary (citable) accession number: Q3AW35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 22, 2005
Last modified: February 28, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome