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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Synechococcus sp. (strain CC9902)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciSSP316279:G1G4V-2392-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:Syncc9902_2311
OrganismiSynechococcus sp. (strain CC9902)
Taxonomic identifieri316279 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000002712 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 31HelicalUniRule annotationAdd BLAST21
Transmembranei42 – 62HelicalUniRule annotationAdd BLAST21
Transmembranei86 – 106HelicalUniRule annotationAdd BLAST21
Transmembranei112 – 132HelicalUniRule annotationAdd BLAST21
Transmembranei152 – 172HelicalUniRule annotationAdd BLAST21
Transmembranei180 – 200HelicalUniRule annotationAdd BLAST21
Transmembranei211 – 231HelicalUniRule annotationAdd BLAST21
Transmembranei239 – 259HelicalUniRule annotationAdd BLAST21
Transmembranei265 – 285HelicalUniRule annotationAdd BLAST21
Transmembranei293 – 313HelicalUniRule annotationAdd BLAST21
Transmembranei347 – 367HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002354911 – 368Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST368

Proteomic databases

PRIDEiQ3AVL6

Interactioni

Protein-protein interaction databases

STRINGi316279.Syncc9902_2311

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY Bacteria
COG0472 LUCA
HOGENOMiHOG000275124
KOiK01000
OMAiLMSPLHH
OrthoDBiPOG091H00VH

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
PF10555 MraY_sig1, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01347 MRAY_1, 1 hit
PS01348 MRAY_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q3AVL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTTETTAQP WWGKGSVSAT LLILFVFAAS LAADKWVSNS QLTLPLLLAA
60 70 80 90 100
VVSMAVAGLG IPRLKALKMG QVIREEGPSG HQSKSGTPTM GGLLVVPVGV
110 120 130 140 150
ILGSWITREP EASQQLLAVS GVTLAYMLIG GFDDWRSLTR RTNTGLTPRG
160 170 180 190 200
KLLLQTTAAF VFLAIAAWQG WINSSVALPF GQSLPLGLLI WPLGLFVFLA
210 220 230 240 250
ESNATNLTDG LDGLASGCGA LVFTGLALQL MLRGNHGDPA LAGYCMTMAG
260 270 280 290 300
TWLGFLVFNR HPARVFMGDT GSLAMGAALT AIALLSNSLW PLLVMGGVFL
310 320 330 340 350
AESLSVIIQV WVFKATKGAD GQGRRVFRMA PLHHHFELGG TSERTLVPCF
360
WTATAALVVL GLLLRPFG
Length:368
Mass (Da):38,913
Last modified:November 22, 2005 - v1
Checksum:iD6A6F1FC3DAFAD6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000097 Genomic DNA Translation: ABB27269.1
RefSeqiWP_011361044.1, NC_007513.1

Genome annotation databases

EnsemblBacteriaiABB27269; ABB27269; Syncc9902_2311
KEGGisye:Syncc9902_2311

Similar proteinsi

Entry informationi

Entry nameiMRAY_SYNS9
AccessioniPrimary (citable) accession number: Q3AVL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: November 22, 2005
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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