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Protein

Bifunctional pantoate ligase/cytidylate kinase

Gene

panC/cmk

Organism
Synechococcus sp. (strain CC9902)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.
ATP + (d)CMP = ADP + (d)CDP.

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional pantoate ligase/cytidylate kinase (panC/cmk)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi259 – 267ATPBy similarity9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Ligase, Transferase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional pantoate ligase/cytidylate kinase
Including the following 2 domains:
Pantoate--beta-alanine ligase (EC:6.3.2.1)
Alternative name(s):
Pantoate-activating enzyme
Pantothenate synthetase
Cytidylate kinase (EC:2.7.4.14)
Short name:
CK
Alternative name(s):
Cytidine monophosphate kinase
Short name:
CMP kinase
Gene namesi
Name:panC/cmk
Ordered Locus Names:Syncc9902_1914
OrganismiSynechococcus sp. (strain CC9902)
Taxonomic identifieri316279 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000002712 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002398001 – 483Bifunctional pantoate ligase/cytidylate kinaseAdd BLAST483

Interactioni

Protein-protein interaction databases

STRINGi316279.Syncc9902_1914.

Structurei

3D structure databases

ProteinModelPortaliQ3AUV1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 246Pantoate--beta-alanine ligaseAdd BLAST246
Regioni247 – 483Cytidylate kinaseAdd BLAST237

Sequence similaritiesi

In the N-terminal section; belongs to the pantothenate synthetase family.Curated
In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105CAT. Bacteria.
COG0283. LUCA.
COG0414. LUCA.
HOGENOMiHOG000233355.
KOiK13799.
OMAiLGEKDWQ.
OrthoDBiPOG091H00FM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00238. Cytidyl_kinase_type1. 1 hit.
MF_00158. PanC. 1 hit.
MF_01349. PanCY. 1 hit.
InterProiIPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
IPR003721. Pantoate_ligase.
IPR024894. Pantoate_ligase/cytidylate_kin.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02224. Cytidylate_kin. 1 hit.
PF02569. Pantoate_ligase. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00017. cmk. 1 hit.
TIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3AUV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTMGALHAG HGTVIRAASA MGPVLVSVFV NPLQFGPDED LARYPRSLES
60 70 80 90 100
DLVVAERWGA AALWAPSVEQ IYPQGGERHP STIQVPPGLQ KHLCGAARPG
110 120 130 140 150
HFDGVVTVVA RLLDLVRPRQ LWLGEKDWQQ LVILRWLVAH LARPVIVQGV
160 170 180 190 200
ATVREADGLA LSSRNQYLSP DQRRMAAALP EALHAARGDG SDPIPALRGS
210 220 230 240 250
LSDAGFEVEY VQRVDPCTLQ PCGDETAISL LAAAVRCGST RLIDHAFLMT
260 270 280 290 300
RQPLVAIDGP AGAGKSTVTR AFAERLGLVY LDTGAMYRSV TWLVLERGVN
310 320 330 340 350
PSDGVAIEPL LKDLDVQLQS LPGGVQQVLV NGEDVSSAIR SPDVTASVSA
360 370 380 390 400
VAAHRCVRQA LTVQQKSMGS KGGLVAEGRD IGTAVFPHAD LKVFLTATVT
410 420 430 440 450
ERARRRALDL EQRGFAVPER AELEAQIAER DRLDSTREEA PLMQADDAIE
460 470 480
LVTDGMDIDA VIEALVRLFR ERVAEEAWPT PQR
Length:483
Mass (Da):52,124
Last modified:November 22, 2005 - v1
Checksum:i32B97AA32D8CBC79
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000097 Genomic DNA. Translation: ABB26871.1.
RefSeqiWP_011360673.1. NC_007513.1.

Genome annotation databases

EnsemblBacteriaiABB26871; ABB26871; Syncc9902_1914.
KEGGisye:Syncc9902_1914.
PATRICi23801367. VBISynSp76179_2122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000097 Genomic DNA. Translation: ABB26871.1.
RefSeqiWP_011360673.1. NC_007513.1.

3D structure databases

ProteinModelPortaliQ3AUV1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi316279.Syncc9902_1914.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB26871; ABB26871; Syncc9902_1914.
KEGGisye:Syncc9902_1914.
PATRICi23801367. VBISynSp76179_2122.

Phylogenomic databases

eggNOGiENOG4105CAT. Bacteria.
COG0283. LUCA.
COG0414. LUCA.
HOGENOMiHOG000233355.
KOiK13799.
OMAiLGEKDWQ.
OrthoDBiPOG091H00FM.

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00238. Cytidyl_kinase_type1. 1 hit.
MF_00158. PanC. 1 hit.
MF_01349. PanCY. 1 hit.
InterProiIPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
IPR003721. Pantoate_ligase.
IPR024894. Pantoate_ligase/cytidylate_kin.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02224. Cytidylate_kin. 1 hit.
PF02569. Pantoate_ligase. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00017. cmk. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPANCY_SYNS9
AccessioniPrimary (citable) accession number: Q3AUV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: November 22, 2005
Last modified: November 2, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.