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Q3AUM0 (GCSP_SYNS9) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Syncc9902_2188
OrganismSynechococcus sp. (strain CC9902) [Complete proteome] [HAMAP]
Taxonomic identifier316279 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus

Protein attributes

Sequence length958 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 958958Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000045623

Amino acid modifications

Modified residue7051N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3AUM0 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: 4509C36FE278452A

FASTA958102,932
        10         20         30         40         50         60 
MTSPFLQRHL GPSETEQHQM LQTLGYQHLD DFIKDVVPDD ILDAAPPRNV LPAGCGEAEA 

        70         80         90        100        110        120 
LADLGTIAAK NLVQRSLIGL GYHGTATPAL IQRHVFENPA WYTAYTPYQA EIAQGRLEAL 

       130        140        150        160        170        180 
LNFQTLISEL TGLPIANASL LDEATAAAEA MGLSFGVCRR PEANRFLVDC HVLPQTWAVL 

       190        200        210        220        230        240 
QTRAEPLGIE LERVDPEQMA FDTRVFGVLL QLPGADGLLW DPTTLIERAH DAGALVTVAI 

       250        260        270        280        290        300 
DPLAQTLFAP VADFGADIAV GSAQRFGVPM GFGGPHAAFF ATREAYKRQI PGRLVGESKD 

       310        320        330        340        350        360 
AEGNPALRLA LQTREQHIRR DKATSNICTA QVLLAVIASF YAVHHGPDGL RAIAERLVGL 

       370        380        390        400        410        420 
RLQFEAGLRT LDVAVEEADR FDTVTVTTTH APAVHAAAAE AGFNLRVLPD GVPASQATGF 

       430        440        450        460        470        480 
GVSFDEFSDQ KEVAHLLEAV ARAVGKPVST APASAANTAL LSLPSRIRPW LTQPAFHRYR 

       490        500        510        520        530        540 
SETELMRYIQ RLVSRDLSLV HGMIPLGSCT MKLNAAAELL PVSWPEFARL HPFAPLDQAL 

       550        560        570        580        590        600 
GYRHLADDLE RWLAALTGFA AVSLQPNAGS QGEYAGLLVI RAWHRSRGDN HRDICLIPTS 

       610        620        630        640        650        660 
AHGTNPASAV MAGLKVVAVA CDAEGNIDQD DLAARATEYA DRLAALMVTY PSTHGVFETG 

       670        680        690        700        710        720 
IRHICEVVHR HGGQVYLDGA NLNAQVGLSR PGAFGADVCH LNLHKTFCIP HGGGGPGVGP 

       730        740        750        760        770        780 
IGVAAHLAPF LPGHPFENQT ASAIGPVSAA ALGSASILPI SWMYLRMMGA DALRQASAVA 

       790        800        810        820        830        840 
LLSANYLAHR LDDHFPVLFR GATGRVAHEC ILDLRPLKRD AGIDVDDIAK RLMDYGFHAP 

       850        860        870        880        890        900 
TVSWPVAGTV MVEPTESESL SELDRFADAL IAIRDEVRAI ETGAMDALNN PLKRAPHTMA 

       910        920        930        940        950 
AVMAEVWDRP YSRQQAAFPL PDQTQNKVWP AVARIDNAFG DRNLICTCPS VEAVAIAA 

« Hide

References

[1]"Complete sequence of Synechococcus sp. CC9902."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CC9902.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000097 Genomic DNA. Translation: ABB27146.1.
RefSeqYP_378189.1. NC_007513.1.

3D structure databases

ProteinModelPortalQ3AUM0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING316279.Syncc9902_2188.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB27146; ABB27146; Syncc9902_2188.
GeneID3742973.
KEGGsye:Syncc9902_2188.
PATRIC23801957. VBISynSp76179_2409.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycSSP316279:GJCI-2223-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_SYNS9
AccessionPrimary (citable) accession number: Q3AUM0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 22, 2005
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families