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Q3AUM0

- GCSP_SYNS9

UniProt

Q3AUM0 - GCSP_SYNS9

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, Syncc9902_2188
Organism
Synechococcus sp. (strain CC9902)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSSP316279:GJCI-2223-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Syncc9902_2188
OrganismiSynechococcus sp. (strain CC9902)
Taxonomic identifieri316279 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000002712: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 958958Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_1000045623Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei705 – 7051N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi316279.Syncc9902_2188.

Structurei

3D structure databases

ProteinModelPortaliQ3AUM0.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3AUM0-1 [UniParc]FASTAAdd to Basket

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MTSPFLQRHL GPSETEQHQM LQTLGYQHLD DFIKDVVPDD ILDAAPPRNV    50
LPAGCGEAEA LADLGTIAAK NLVQRSLIGL GYHGTATPAL IQRHVFENPA 100
WYTAYTPYQA EIAQGRLEAL LNFQTLISEL TGLPIANASL LDEATAAAEA 150
MGLSFGVCRR PEANRFLVDC HVLPQTWAVL QTRAEPLGIE LERVDPEQMA 200
FDTRVFGVLL QLPGADGLLW DPTTLIERAH DAGALVTVAI DPLAQTLFAP 250
VADFGADIAV GSAQRFGVPM GFGGPHAAFF ATREAYKRQI PGRLVGESKD 300
AEGNPALRLA LQTREQHIRR DKATSNICTA QVLLAVIASF YAVHHGPDGL 350
RAIAERLVGL RLQFEAGLRT LDVAVEEADR FDTVTVTTTH APAVHAAAAE 400
AGFNLRVLPD GVPASQATGF GVSFDEFSDQ KEVAHLLEAV ARAVGKPVST 450
APASAANTAL LSLPSRIRPW LTQPAFHRYR SETELMRYIQ RLVSRDLSLV 500
HGMIPLGSCT MKLNAAAELL PVSWPEFARL HPFAPLDQAL GYRHLADDLE 550
RWLAALTGFA AVSLQPNAGS QGEYAGLLVI RAWHRSRGDN HRDICLIPTS 600
AHGTNPASAV MAGLKVVAVA CDAEGNIDQD DLAARATEYA DRLAALMVTY 650
PSTHGVFETG IRHICEVVHR HGGQVYLDGA NLNAQVGLSR PGAFGADVCH 700
LNLHKTFCIP HGGGGPGVGP IGVAAHLAPF LPGHPFENQT ASAIGPVSAA 750
ALGSASILPI SWMYLRMMGA DALRQASAVA LLSANYLAHR LDDHFPVLFR 800
GATGRVAHEC ILDLRPLKRD AGIDVDDIAK RLMDYGFHAP TVSWPVAGTV 850
MVEPTESESL SELDRFADAL IAIRDEVRAI ETGAMDALNN PLKRAPHTMA 900
AVMAEVWDRP YSRQQAAFPL PDQTQNKVWP AVARIDNAFG DRNLICTCPS 950
VEAVAIAA 958
Length:958
Mass (Da):102,932
Last modified:November 22, 2005 - v1
Checksum:i4509C36FE278452A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000097 Genomic DNA. Translation: ABB27146.1.
RefSeqiWP_011360925.1. NC_007513.1.
YP_378189.1. NC_007513.1.

Genome annotation databases

EnsemblBacteriaiABB27146; ABB27146; Syncc9902_2188.
GeneIDi3742973.
KEGGisye:Syncc9902_2188.
PATRICi23801957. VBISynSp76179_2409.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000097 Genomic DNA. Translation: ABB27146.1 .
RefSeqi WP_011360925.1. NC_007513.1.
YP_378189.1. NC_007513.1.

3D structure databases

ProteinModelPortali Q3AUM0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316279.Syncc9902_2188.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB27146 ; ABB27146 ; Syncc9902_2188 .
GeneIDi 3742973.
KEGGi sye:Syncc9902_2188.
PATRICi 23801957. VBISynSp76179_2409.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci SSP316279:GJCI-2223-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Synechococcus sp. CC9902."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CC9902.

Entry informationi

Entry nameiGCSP_SYNS9
AccessioniPrimary (citable) accession number: Q3AUM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 22, 2005
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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