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Q3AUM0

- GCSP_SYNS9

UniProt

Q3AUM0 - GCSP_SYNS9

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Synechococcus sp. (strain CC9902)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciSSP316279:GJCI-2223-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Syncc9902_2188
    OrganismiSynechococcus sp. (strain CC9902)
    Taxonomic identifieri316279 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000002712: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 958958Glycine dehydrogenase (decarboxylating)PRO_1000045623Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei705 – 7051N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi316279.Syncc9902_2188.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3AUM0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3AUM0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSPFLQRHL GPSETEQHQM LQTLGYQHLD DFIKDVVPDD ILDAAPPRNV    50
    LPAGCGEAEA LADLGTIAAK NLVQRSLIGL GYHGTATPAL IQRHVFENPA 100
    WYTAYTPYQA EIAQGRLEAL LNFQTLISEL TGLPIANASL LDEATAAAEA 150
    MGLSFGVCRR PEANRFLVDC HVLPQTWAVL QTRAEPLGIE LERVDPEQMA 200
    FDTRVFGVLL QLPGADGLLW DPTTLIERAH DAGALVTVAI DPLAQTLFAP 250
    VADFGADIAV GSAQRFGVPM GFGGPHAAFF ATREAYKRQI PGRLVGESKD 300
    AEGNPALRLA LQTREQHIRR DKATSNICTA QVLLAVIASF YAVHHGPDGL 350
    RAIAERLVGL RLQFEAGLRT LDVAVEEADR FDTVTVTTTH APAVHAAAAE 400
    AGFNLRVLPD GVPASQATGF GVSFDEFSDQ KEVAHLLEAV ARAVGKPVST 450
    APASAANTAL LSLPSRIRPW LTQPAFHRYR SETELMRYIQ RLVSRDLSLV 500
    HGMIPLGSCT MKLNAAAELL PVSWPEFARL HPFAPLDQAL GYRHLADDLE 550
    RWLAALTGFA AVSLQPNAGS QGEYAGLLVI RAWHRSRGDN HRDICLIPTS 600
    AHGTNPASAV MAGLKVVAVA CDAEGNIDQD DLAARATEYA DRLAALMVTY 650
    PSTHGVFETG IRHICEVVHR HGGQVYLDGA NLNAQVGLSR PGAFGADVCH 700
    LNLHKTFCIP HGGGGPGVGP IGVAAHLAPF LPGHPFENQT ASAIGPVSAA 750
    ALGSASILPI SWMYLRMMGA DALRQASAVA LLSANYLAHR LDDHFPVLFR 800
    GATGRVAHEC ILDLRPLKRD AGIDVDDIAK RLMDYGFHAP TVSWPVAGTV 850
    MVEPTESESL SELDRFADAL IAIRDEVRAI ETGAMDALNN PLKRAPHTMA 900
    AVMAEVWDRP YSRQQAAFPL PDQTQNKVWP AVARIDNAFG DRNLICTCPS 950
    VEAVAIAA 958
    Length:958
    Mass (Da):102,932
    Last modified:November 22, 2005 - v1
    Checksum:i4509C36FE278452A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000097 Genomic DNA. Translation: ABB27146.1.
    RefSeqiWP_011360925.1. NC_007513.1.
    YP_378189.1. NC_007513.1.

    Genome annotation databases

    EnsemblBacteriaiABB27146; ABB27146; Syncc9902_2188.
    GeneIDi3742973.
    KEGGisye:Syncc9902_2188.
    PATRICi23801957. VBISynSp76179_2409.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000097 Genomic DNA. Translation: ABB27146.1 .
    RefSeqi WP_011360925.1. NC_007513.1.
    YP_378189.1. NC_007513.1.

    3D structure databases

    ProteinModelPortali Q3AUM0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 316279.Syncc9902_2188.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB27146 ; ABB27146 ; Syncc9902_2188 .
    GeneIDi 3742973.
    KEGGi sye:Syncc9902_2188.
    PATRICi 23801957. VBISynSp76179_2409.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci SSP316279:GJCI-2223-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Synechococcus sp. CC9902."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CC9902.

    Entry informationi

    Entry nameiGCSP_SYNS9
    AccessioniPrimary (citable) accession number: Q3AUM0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3