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Q3AUM0

- GCSP_SYNS9

UniProt

Q3AUM0 - GCSP_SYNS9

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Synechococcus sp. (strain CC9902)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSSP316279:GJCI-2223-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Syncc9902_2188
OrganismiSynechococcus sp. (strain CC9902)
Taxonomic identifieri316279 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000002712: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 958958Glycine dehydrogenase (decarboxylating)PRO_1000045623Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei705 – 7051N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi316279.Syncc9902_2188.

Structurei

3D structure databases

ProteinModelPortaliQ3AUM0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3AUM0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSPFLQRHL GPSETEQHQM LQTLGYQHLD DFIKDVVPDD ILDAAPPRNV
60 70 80 90 100
LPAGCGEAEA LADLGTIAAK NLVQRSLIGL GYHGTATPAL IQRHVFENPA
110 120 130 140 150
WYTAYTPYQA EIAQGRLEAL LNFQTLISEL TGLPIANASL LDEATAAAEA
160 170 180 190 200
MGLSFGVCRR PEANRFLVDC HVLPQTWAVL QTRAEPLGIE LERVDPEQMA
210 220 230 240 250
FDTRVFGVLL QLPGADGLLW DPTTLIERAH DAGALVTVAI DPLAQTLFAP
260 270 280 290 300
VADFGADIAV GSAQRFGVPM GFGGPHAAFF ATREAYKRQI PGRLVGESKD
310 320 330 340 350
AEGNPALRLA LQTREQHIRR DKATSNICTA QVLLAVIASF YAVHHGPDGL
360 370 380 390 400
RAIAERLVGL RLQFEAGLRT LDVAVEEADR FDTVTVTTTH APAVHAAAAE
410 420 430 440 450
AGFNLRVLPD GVPASQATGF GVSFDEFSDQ KEVAHLLEAV ARAVGKPVST
460 470 480 490 500
APASAANTAL LSLPSRIRPW LTQPAFHRYR SETELMRYIQ RLVSRDLSLV
510 520 530 540 550
HGMIPLGSCT MKLNAAAELL PVSWPEFARL HPFAPLDQAL GYRHLADDLE
560 570 580 590 600
RWLAALTGFA AVSLQPNAGS QGEYAGLLVI RAWHRSRGDN HRDICLIPTS
610 620 630 640 650
AHGTNPASAV MAGLKVVAVA CDAEGNIDQD DLAARATEYA DRLAALMVTY
660 670 680 690 700
PSTHGVFETG IRHICEVVHR HGGQVYLDGA NLNAQVGLSR PGAFGADVCH
710 720 730 740 750
LNLHKTFCIP HGGGGPGVGP IGVAAHLAPF LPGHPFENQT ASAIGPVSAA
760 770 780 790 800
ALGSASILPI SWMYLRMMGA DALRQASAVA LLSANYLAHR LDDHFPVLFR
810 820 830 840 850
GATGRVAHEC ILDLRPLKRD AGIDVDDIAK RLMDYGFHAP TVSWPVAGTV
860 870 880 890 900
MVEPTESESL SELDRFADAL IAIRDEVRAI ETGAMDALNN PLKRAPHTMA
910 920 930 940 950
AVMAEVWDRP YSRQQAAFPL PDQTQNKVWP AVARIDNAFG DRNLICTCPS

VEAVAIAA
Length:958
Mass (Da):102,932
Last modified:November 22, 2005 - v1
Checksum:i4509C36FE278452A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000097 Genomic DNA. Translation: ABB27146.1.
RefSeqiWP_011360925.1. NC_007513.1.
YP_378189.1. NC_007513.1.

Genome annotation databases

EnsemblBacteriaiABB27146; ABB27146; Syncc9902_2188.
GeneIDi3742973.
KEGGisye:Syncc9902_2188.
PATRICi23801957. VBISynSp76179_2409.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000097 Genomic DNA. Translation: ABB27146.1 .
RefSeqi WP_011360925.1. NC_007513.1.
YP_378189.1. NC_007513.1.

3D structure databases

ProteinModelPortali Q3AUM0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316279.Syncc9902_2188.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB27146 ; ABB27146 ; Syncc9902_2188 .
GeneIDi 3742973.
KEGGi sye:Syncc9902_2188.
PATRICi 23801957. VBISynSp76179_2409.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci SSP316279:GJCI-2223-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Synechococcus sp. CC9902."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CC9902.

Entry informationi

Entry nameiGCSP_SYNS9
AccessioniPrimary (citable) accession number: Q3AUM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 22, 2005
Last modified: November 26, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3