Reviewed,
UniProtKB/Swiss-Prot Q3AUB7 (DCUP_CHLCH)
Last modified
February 9, 2010.
Version 33.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Uroporphyrinogen decarboxylase Short name=URO-D Short name=UPD EC=4.1.1.37 | ||||
| Gene names |
| ||||
| Organism | Chlorobium chlorochromatii (strain CaD3) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 340177 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobium/Pelodictyon group › Chlorobium |
Protein attributes
| Sequence length | 351 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218 |
| Catalytic activity | Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218 |
| Pathway | Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218 |
| Subunit structure | Homodimer By similarity. HAMAP MF_00218 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00218. |
| Sequence similarities | Belongs to the uroporphyrinogen decarboxylase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Porphyrin biosynthesis |
| Cellular component | Cytoplasm |
| Molecular function | Decarboxylase Lyase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | porphyrin biosynthetic process Inferred from electronic annotation. Source: HAMAP |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | uroporphyrinogen decarboxylase activity Inferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 351 | 351 | Uroporphyrinogen decarboxylase HAMAP MF_00218 | PRO_1000023895 | |||||
Regions | |||||||||
| Region | 25 – 29 | 5 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Binding site | 74 | 1 | Substrate By similarity | ||||||
| Binding site | 151 | 1 | Substrate By similarity | ||||||
| Binding site | 206 | 1 | Substrate By similarity | ||||||
| Binding site | 325 | 1 | Substrate By similarity | ||||||
| Site | 74 | 1 | Transition state stabilizer By similarity | ||||||
Sequences
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References
| [1] | "Complete sequence of Chlorobium chlorochromatii CaD3." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Bryant D., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000108 Genomic DNA. Translation: ABB27408.1. |
| RefSeq | YP_378451.1. |
3D structure databases | |
| SMR | Q3AUB7. Positions 2-351. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q3AUB7. |
Genome annotation databases | |
| GeneID | 3747081. |
| GenomeReviews | Gene locus Cag_0130 in contig CP000108_GR. |
| KEGG | cch:Cag_0130. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0407. |
| HOGENOM | HBG628392. |
| OMA | QIFDTWG. |
Enzyme and pathway databases | |
| BioCyc | CCHL340177:CAG_0130-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00218. URO-D. [Tree] |
| InterPro | IPR006361. Uroporphyrinogen_deCO2ase_HemE. IPR000257. Uroporphyrinogen_deCOase. [Graphical view] |
| PANTHER | PTHR21091:SF2. HemE. 1 hit. |
| Pfam | PF01208. URO-D. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01464. hemE. 1 hit. |
| PROSITE | PS00906. UROD_1. 1 hit. PS00907. UROD_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DCUP_CHLCH | ||||||||
| Accession | Primary (citable) accession number: Q3AUB7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


