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Q3AUB7 (DCUP_CHLCH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37
Gene names
Name:hemE
Ordered Locus Names:Cag_0130
OrganismChlorobium chlorochromatii (strain CaD3) [Complete proteome] [HAMAP]
Taxonomic identifier340177 [NCBI]
Taxonomic lineageBacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobium/Pelodictyon group › Chlorobium

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity. HAMAP MF_00218

Subcellular location

Cytoplasm By similarity HAMAP MF_00218.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 351351Uroporphyrinogen decarboxylase HAMAP MF_00218
PRO_1000023895

Regions

Region25 – 295Substrate binding By similarity

Sites

Binding site741Substrate By similarity
Binding site1511Substrate By similarity
Binding site2061Substrate By similarity
Binding site3251Substrate By similarity
Site741Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3AUB7 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: 114178F38C09201B

FASTA35139,185
        10         20         30         40         50         60 
MLKNDLFLRA LKRQPCSRTP IWVMRQAGRY LPEYRAVREK TDFLTLCKTP ELATEVTIQP 

        70         80         90        100        110        120 
VELVGVDAAI IFSDILVVNE AMGQEVNIIE TKGIKLAPPI RSQADIDKLI VPDIDEKLGY 

       130        140        150        160        170        180 
VLDALRMTKK ELDNRVPLIG FSGAAWTLFT YAVEGGGSKN YAYAKQMMYR EPQMAHSLLS 

       190        200        210        220        230        240 
KISQTITAYT LKQIEAGADA IQIFDSWASA LSEDDYREYA LPYIKDTVQA IKAKHPETPV 

       250        260        270        280        290        300 
IVFSKDCNTI LSDIADTGCD AVGLGWGIDI SKARTELNDR VALQGNLDPT VLYGTQERIK 

       310        320        330        340        350 
IEAGKILKSF GQHNHHSGHV FNLGHGILPD MDPDNLRCLV EFVKEESAKY H

« Hide

References

[1]"Complete sequence of Chlorobium chlorochromatii CaD3."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Bryant D., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CaD3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000108 Genomic DNA. Translation: ABB27408.1.
RefSeqYP_378451.1. NC_007514.1.

3D structure databases

ProteinModelPortalQ3AUB7.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3AUB7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3747081.
GenomeReviewsGene locus Cag_0130 in contig CP000108_GR.
KEGGcch:Cag_0130.
PATRIC21367809. VBIChlChl46571_0138.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0407.
HOGENOMHBG628392.
OMAPRIHFGV.
PhylomeDBQ3AUB7.
ProtClustDBPRK00115.

Enzyme and pathway databases

BioCycCCHL340177:CAG_0130-MONOMER.

Family and domain databases

HAMAPMF_00218. URO-D.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
KOK01599.
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. HemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDCUP_CHLCH
AccessionPrimary (citable) accession number: Q3AUB7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 22, 2005
Last modified: January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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