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Q3ATZ1 (PUR9_CHLCH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:Cag_0258
OrganismChlorobium chlorochromatii (strain CaD3) [Complete proteome] [HAMAP]
Taxonomic identifier340177 [NCBI]
Taxonomic lineageBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium

Protein attributes

Sequence length524 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 524524Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_1000018871

Sequences

Sequence LengthMass (Da)Tools
Q3ATZ1 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: ECD190F75E7FD27C

FASTA52456,980
        10         20         30         40         50         60 
MSDPVIKRAL VSVSDKTGIV DFCRELSELG VEIFSTGGTL KTLQDAGIAA ASISTITGFP 

        70         80         90        100        110        120 
EIMDGRVKTL HPKIHGGLLA VRENANHVKQ AADNGISFID LVVVNLYPFE ATVAKPNVSF 

       130        140        150        160        170        180 
EDAIENIDIG GPSMLRSAAK NNESVTVVTD SADYALVLQE MRANNGATTR ATRLHLALKV 

       190        200        210        220        230        240 
FELTSRYDRA IATYLAGKVS AAEAAASTMS VQLAKELDMR YGENPHQNAG LYRLTDSNGT 

       250        260        270        280        290        300 
RSFEEFFEKL HGKELSYNNM LDIAAATSLI EEFRGEEPTV VIIKHTNPCG VAQASSLVDA 

       310        320        330        340        350        360 
WHRAFSTDTQ APFGGIVAFN RPLDMAAAQA VNEIFTEILI APAFEDGVLE LLMKKKDRRL 

       370        380        390        400        410        420 
VVQKKALPQS GWEFKSTPFG MLVQERDSKI VAKEDLKVVT KRQPTEAEIA DLMFAWKICK 

       430        440        450        460        470        480 
HIKSNTILYV KNRQTYGVGA GQMSRVDSSK IARWKASEVN LDLHGSVVAS DAFFPFADGL 

       490        500        510        520 
LAAAEAGVTA VIQPGGSIRD NEVIEAADAN NLAMVFTGMR HFKH 

« Hide

References

[1]"Complete sequence of Chlorobium chlorochromatii CaD3."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Bryant D., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CaD3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000108 Genomic DNA. Translation: ABB27534.1.
RefSeqYP_378577.1. NC_007514.1.

3D structure databases

ProteinModelPortalQ3ATZ1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING340177.Cag_0258.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB27534; ABB27534; Cag_0258.
GeneID3748179.
KEGGcch:Cag_0258.
PATRIC21368089. VBIChlChl46571_0276.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230373.
KOK00602.
OMALKSTLRY.
OrthoDBEOG6QCDFF.

Enzyme and pathway databases

BioCycCCHL340177:GHBW-264-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_CHLCH
AccessionPrimary (citable) accession number: Q3ATZ1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 22, 2005
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways