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Q3ATN0

- GCH1_CHLCH

UniProt

Q3ATN0 - GCH1_CHLCH

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Protein

GTP cyclohydrolase 1

Gene
folE, Cag_0372
Organism
Chlorobium chlorochromatii (strain CaD3)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi114 – 1141Zinc By similarity
Metal bindingi117 – 1171Zinc By similarity
Metal bindingi185 – 1851Zinc By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. one-carbon metabolic process Source: UniProtKB-HAMAP
  3. tetrahydrofolate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

GTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciCCHL340177:GHBW-380-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase 1 (EC:3.5.4.16)
Alternative name(s):
GTP cyclohydrolase I
Short name:
GTP-CH-I
Gene namesi
Name:folE
Ordered Locus Names:Cag_0372
OrganismiChlorobium chlorochromatii (strain CaD3)
Taxonomic identifieri340177 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
ProteomesiUP000002708: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223GTP cyclohydrolase 1UniRule annotationPRO_1000078137Add
BLAST

Interactioni

Subunit structurei

Homopolymer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi340177.Cag_0372.

Structurei

3D structure databases

ProteinModelPortaliQ3ATN0.
SMRiQ3ATN0. Positions 39-222.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0302.
HOGENOMiHOG000221222.
KOiK01495.
OMAiESAVYTM.
OrthoDBiEOG6XHC8G.

Family and domain databases

HAMAPiMF_00223. FolE.
InterProiIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERiPTHR11109. PTHR11109. 1 hit.
PfamiPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00063. folE. 1 hit.
PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3ATN0-1 [UniParc]FASTAAdd to Basket

« Hide

MKQEKTPSAI TENKLPFSSS NCGCGCHNDD DTLTHDDGLL TDNLESAVYT    50
MLQNVGEDPQ REGLLKTPER VARSMRFLTK GYHENPEELL QKALFTESYD 100
EMVLVRDIDL FSMCEHHMLP FFGKAHVAYI PDGKIVGLSK LARVVEVFSR 150
RLQVQERLTQ QIRDAIQNVL NPKGVAVVIE AKHLCMVMRG VEKLNSITTT 200
SAMSGVFMTS PSTRGEFLRL IQK 223
Length:223
Mass (Da):25,103
Last modified:November 22, 2005 - v1
Checksum:iDF8C34CD8292D60E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000108 Genomic DNA. Translation: ABB27645.1.
RefSeqiYP_378688.1. NC_007514.1.

Genome annotation databases

EnsemblBacteriaiABB27645; ABB27645; Cag_0372.
GeneIDi3748017.
KEGGicch:Cag_0372.
PATRICi21368321. VBIChlChl46571_0387.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000108 Genomic DNA. Translation: ABB27645.1 .
RefSeqi YP_378688.1. NC_007514.1.

3D structure databases

ProteinModelPortali Q3ATN0.
SMRi Q3ATN0. Positions 39-222.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 340177.Cag_0372.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB27645 ; ABB27645 ; Cag_0372 .
GeneIDi 3748017.
KEGGi cch:Cag_0372.
PATRICi 21368321. VBIChlChl46571_0387.

Phylogenomic databases

eggNOGi COG0302.
HOGENOMi HOG000221222.
KOi K01495.
OMAi ESAVYTM.
OrthoDBi EOG6XHC8G.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci CCHL340177:GHBW-380-MONOMER.

Family and domain databases

HAMAPi MF_00223. FolE.
InterProi IPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view ]
PANTHERi PTHR11109. PTHR11109. 1 hit.
Pfami PF01227. GTP_cyclohydroI. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00063. folE. 1 hit.
PROSITEi PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Chlorobium chlorochromatii CaD3."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Bryant D., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CaD3.

Entry informationi

Entry nameiGCH1_CHLCH
AccessioniPrimary (citable) accession number: Q3ATN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 22, 2005
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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