Reviewed, UniProtKB/Swiss-Prot Q3AR93 (AROK_CHLCH)

Names and origin

Protein names

Recommended name:
    Shikimate kinase
      Short name=SK
    EC=2.7.1.71

Gene names

Name:	aroK
Ordered Locus Names:	Cag_1220

Organism

Chlorobium chlorochromatii (strain CaD3) [Complete proteome] [HAMAP]

Taxonomic identifier

340177 [NCBI]

Taxonomic lineage

Bacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobium/Pelodictyon group › Chlorobium

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate By similarity. HAMAP MF_00109
Catalytic activity	ATP + shikimate = ADP + shikimate 3-phosphate. HAMAP MF_00109
Cofactor	Binds 1 magnesium ion per subunit By similarity. HAMAP MF_00109
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7. HAMAP MF_00109
Subunit structure	Monomer By similarity. HAMAP MF_00109
Subcellular location	Cytoplasm Probable HAMAP MF_00109.
Sequence similarities	Belongs to the shikimate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP shikimate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 190	190	Shikimate kinase HAMAP MF_00109		PRO_0000237863
Regions
	Nucleotide binding	15 – 20	6	ATP By similarity
Sites
	Metal binding	19	1	Magnesium By similarity
	Binding site	37	1	Substrate By similarity
	Binding site	61	1	Substrate By similarity
	Binding site	83	1	Substrate; via amide nitrogen By similarity
	Binding site	121	1	ATP By similarity
	Binding site	148	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3AR93-1 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 895D16622A9162D9	FASTA	190	21,288
	10 20 30 40 50 60 MQKEPSLIFL TGFSGSGKST IGPLLANSLG YEFVDLDALI ERECGKSINQ IFAEAGEAAF 70 80 90 100 110 120 RQHEEQTLET LLMRRKTVVS LGGGVLEQPR AFELVRQAGT VVYLKSPVKT LARRLSNKTD 130 140 150 160 170 180 RPLLKGEQGE KLSQEEIEQK IAELLARREP RYECADITVE TDAKRIGSTV EELTRKIERY 190 MRTLALSSEE

References

[1]

"Complete sequence of Chlorobium chlorochromatii CaD3." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Bryant D., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000108 Genomic DNA. Translation: ABB28482.1.
RefSeq	YP_379525.1.
3D structure databases
SMR	Q3AR93. Positions 6-177.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3AR93.
Genome annotation databases
GeneID	3748254.
GenomeReviews	Gene locus Cag_1220 in contig CP000108_GR.
KEGG	cch:Cag_1220.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0703.
HOGENOM	HBG335815.
OMA	HANVFFV.
Enzyme and pathway databases
BioCyc	CCHL340177:CAG_1220-MONOMER.
Family and domain databases
HAMAP	MF_00109. Shikimate_kinase. [Tree]
InterPro	IPR000623. Shik_kinase. [Graphical view]
Pfam	PF01202. SKI. 1 hit. [Graphical view]
PRINTS	PR01100. SHIKIMTKNASE.
PROSITE	PS01128. SHIKIMATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROK_CHLCH

Accession

Primary (citable) accession number: Q3AR93

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	November 22, 2005
Last modified:	January 19, 2010
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)