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Q3AR25

- HISX_CHLCH

UniProt

Q3AR25 - HISX_CHLCH

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Protein
Histidinol dehydrogenase
Gene
hisD, Cag_1289
Organism
Chlorobium chlorochromatii (strain CaD3)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei126 – 1261NAD By similarity
Binding sitei188 – 1881NAD By similarity
Binding sitei211 – 2111NAD By similarity
Binding sitei234 – 2341Substrate By similarity
Metal bindingi256 – 2561Zinc By similarity
Binding sitei256 – 2561Substrate By similarity
Metal bindingi259 – 2591Zinc By similarity
Binding sitei259 – 2591Substrate By similarity
Active sitei324 – 3241Proton acceptor By similarity
Active sitei325 – 3251Proton acceptor By similarity
Binding sitei325 – 3251Substrate By similarity
Metal bindingi358 – 3581Zinc By similarity
Binding sitei358 – 3581Substrate By similarity
Binding sitei412 – 4121Substrate By similarity
Metal bindingi417 – 4171Zinc By similarity
Binding sitei417 – 4171Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciCCHL340177:GHBW-1304-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:Cag_1289
OrganismiChlorobium chlorochromatii (strain CaD3)
Taxonomic identifieri340177 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
ProteomesiUP000002708: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Histidinol dehydrogenaseUniRule annotation
PRO_0000229855Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi340177.Cag_1289.

Structurei

3D structure databases

ProteinModelPortaliQ3AR25.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiFQEITRE.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3AR25-1 [UniParc]FASTAAdd to Basket

« Hide

MLPLYRFPQE ASALQERLVR HVSFDEAAHK AVDEILAKVR QQGDRAVLNY    50
TEQFQGVRLT SMQVDEEAIE MAYRHADPSL IATLHEAYAN IVRFHEHEVE 100
RSFFYEAEGG VLLGQRVRPM ERAMLYVPGG KAAYPSSLLM NAAPAKVAGV 150
CEIAVTTPCD ATGVVNPTIL AAAKVAGISS IYKIGGAQAV AAFAYGTESI 200
PKVDIITGPG NKYVALAKKQ VFGHVAIDSI AGPSEVVIIA DESAHAEFVA 250
LDMFAQAEHD PDASAVLITT SESFAQAVQQ AVASLLPTML RHETIASSLL 300
HNGAMVLVPS LDDACAVSDM LAPEHLELHV VQPWDILPKL KHAGAIFMGS 350
YSCETIGDYF AGPNHTLPTS GTARFFSPLS VRDFVKHTSI ISYSPEQLRS 400
KGAQIAAFAD AEGLQAHAEA VRVRLKTL 428
Length:428
Mass (Da):46,058
Last modified:November 22, 2005 - v1
Checksum:i9C84F276D42A901E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000108 Genomic DNA. Translation: ABB28550.1.
RefSeqiWP_011362314.1. NC_007514.1.
YP_379593.1. NC_007514.1.

Genome annotation databases

EnsemblBacteriaiABB28550; ABB28550; Cag_1289.
GeneIDi3747438.
KEGGicch:Cag_1289.
PATRICi21370289. VBIChlChl46571_1349.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000108 Genomic DNA. Translation: ABB28550.1 .
RefSeqi WP_011362314.1. NC_007514.1.
YP_379593.1. NC_007514.1.

3D structure databases

ProteinModelPortali Q3AR25.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 340177.Cag_1289.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB28550 ; ABB28550 ; Cag_1289 .
GeneIDi 3747438.
KEGGi cch:Cag_1289.
PATRICi 21370289. VBIChlChl46571_1349.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi FQEITRE.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci CCHL340177:GHBW-1304-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Chlorobium chlorochromatii CaD3."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Bryant D., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CaD3.

Entry informationi

Entry nameiHISX_CHLCH
AccessioniPrimary (citable) accession number: Q3AR25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 22, 2005
Last modified: September 3, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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