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Reviewed, UniProtKB/Swiss-Prot Q3AR25 (HISX_CHLCH)

Last modified November 25, 2008. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Histidinol dehydrogenase
      Short name=HDH
    EC=1.1.1.23
Gene names
Name: hisD
Ordered Locus Names: Cag_1289
OrganismChlorobium chlorochromatii (strain CaD3) [Complete proteome] [HAMAP]
Taxonomic identifier340177 [NCBI]
Taxonomic lineageBacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobium/Pelodictyon group › Chlorobium

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Protein attributes

Sequence length428 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.

Catalytic activity

L-histidinol + 2 NAD(+) = L-histidine + 2 NADH.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.

Sequence similarities

Belongs to the histidinol dehydrogenase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 428428Histidinol dehydrogenase
PRO_0000229855

Sites

Active site3241Proton acceptor By similarity
Active site3251Proton acceptor By similarity
Metal binding2561Zinc By similarity
Metal binding2591Zinc By similarity
Metal binding3581Zinc By similarity
Metal binding4171Zinc By similarity
Binding site1261NAD By similarity
Binding site1881NAD By similarity
Binding site2111NAD By similarity
Binding site2341Substrate By similarity
Binding site2561Substrate By similarity
Binding site2591Substrate By similarity
Binding site3251Substrate By similarity
Binding site3581Substrate By similarity
Binding site4121Substrate By similarity
Binding site4171Substrate By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q3AR25-1 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: 9C84F276D42A901E

FASTA42846,058
        10         20         30         40         50         60 
MLPLYRFPQE ASALQERLVR HVSFDEAAHK AVDEILAKVR QQGDRAVLNY TEQFQGVRLT 

        70         80         90        100        110        120 
SMQVDEEAIE MAYRHADPSL IATLHEAYAN IVRFHEHEVE RSFFYEAEGG VLLGQRVRPM 

       130        140        150        160        170        180 
ERAMLYVPGG KAAYPSSLLM NAAPAKVAGV CEIAVTTPCD ATGVVNPTIL AAAKVAGISS 

       190        200        210        220        230        240 
IYKIGGAQAV AAFAYGTESI PKVDIITGPG NKYVALAKKQ VFGHVAIDSI AGPSEVVIIA 

       250        260        270        280        290        300 
DESAHAEFVA LDMFAQAEHD PDASAVLITT SESFAQAVQQ AVASLLPTML RHETIASSLL 

       310        320        330        340        350        360 
HNGAMVLVPS LDDACAVSDM LAPEHLELHV VQPWDILPKL KHAGAIFMGS YSCETIGDYF 

       370        380        390        400        410        420 
AGPNHTLPTS GTARFFSPLS VRDFVKHTSI ISYSPEQLRS KGAQIAAFAD AEGLQAHAEA 


VRVRLKTL

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References

[1]"Complete sequence of Chlorobium chlorochromatii CaD3."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Bryant D., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000108 Genomic DNA. Translation: ABB28550.1.
RefSeqYP_379593.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3747438.
GenomeReviewsGene locus Cag_1289 in contig CP000108_GR.
KEGGcch:Cag_1289.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ3AR25.

Enzyme and pathway databases

BioCycCCHL340177:CAG_1289-MON.

Family and domain databases

HAMAPMF_01024.
[Tree]
InterProIPR001692. Histidinol_DHase.
IPR012131. Hstdl_DHase_prok.
[Graphical view]
PANTHERPTHR21256:SF2. Hstdl_DH_prok. 1 hit.
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PRINTSPR00083. HOLDHDRGNASE.
ProDomPD002680. Histidinol_dh. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameHISX_CHLCH
AccessionPrimary (citable) accession number: Q3AR25
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 22, 2005
Last modified: November 25, 2008
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents