Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q3AR25

- HISX_CHLCH

UniProt

Q3AR25 - HISX_CHLCH

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Chlorobium chlorochromatii (strain CaD3)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei126 – 1261NADUniRule annotation
Binding sitei188 – 1881NADUniRule annotation
Binding sitei211 – 2111NADUniRule annotation
Binding sitei234 – 2341SubstrateUniRule annotation
Metal bindingi256 – 2561ZincUniRule annotation
Binding sitei256 – 2561SubstrateUniRule annotation
Metal bindingi259 – 2591ZincUniRule annotation
Binding sitei259 – 2591SubstrateUniRule annotation
Active sitei324 – 3241Proton acceptorUniRule annotation
Active sitei325 – 3251Proton acceptorUniRule annotation
Binding sitei325 – 3251SubstrateUniRule annotation
Metal bindingi358 – 3581ZincUniRule annotation
Binding sitei358 – 3581SubstrateUniRule annotation
Binding sitei412 – 4121SubstrateUniRule annotation
Metal bindingi417 – 4171ZincUniRule annotation
Binding sitei417 – 4171SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciCCHL340177:GHBW-1304-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:Cag_1289
OrganismiChlorobium chlorochromatii (strain CaD3)
Taxonomic identifieri340177 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
ProteomesiUP000002708: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Histidinol dehydrogenasePRO_0000229855Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi340177.Cag_1289.

Structurei

3D structure databases

ProteinModelPortaliQ3AR25.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiFQEITRE.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3AR25-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLPLYRFPQE ASALQERLVR HVSFDEAAHK AVDEILAKVR QQGDRAVLNY
60 70 80 90 100
TEQFQGVRLT SMQVDEEAIE MAYRHADPSL IATLHEAYAN IVRFHEHEVE
110 120 130 140 150
RSFFYEAEGG VLLGQRVRPM ERAMLYVPGG KAAYPSSLLM NAAPAKVAGV
160 170 180 190 200
CEIAVTTPCD ATGVVNPTIL AAAKVAGISS IYKIGGAQAV AAFAYGTESI
210 220 230 240 250
PKVDIITGPG NKYVALAKKQ VFGHVAIDSI AGPSEVVIIA DESAHAEFVA
260 270 280 290 300
LDMFAQAEHD PDASAVLITT SESFAQAVQQ AVASLLPTML RHETIASSLL
310 320 330 340 350
HNGAMVLVPS LDDACAVSDM LAPEHLELHV VQPWDILPKL KHAGAIFMGS
360 370 380 390 400
YSCETIGDYF AGPNHTLPTS GTARFFSPLS VRDFVKHTSI ISYSPEQLRS
410 420
KGAQIAAFAD AEGLQAHAEA VRVRLKTL
Length:428
Mass (Da):46,058
Last modified:November 22, 2005 - v1
Checksum:i9C84F276D42A901E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000108 Genomic DNA. Translation: ABB28550.1.
RefSeqiYP_379593.1. NC_007514.1.

Genome annotation databases

EnsemblBacteriaiABB28550; ABB28550; Cag_1289.
GeneIDi3747438.
KEGGicch:Cag_1289.
PATRICi21370289. VBIChlChl46571_1349.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000108 Genomic DNA. Translation: ABB28550.1 .
RefSeqi YP_379593.1. NC_007514.1.

3D structure databases

ProteinModelPortali Q3AR25.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 340177.Cag_1289.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB28550 ; ABB28550 ; Cag_1289 .
GeneIDi 3747438.
KEGGi cch:Cag_1289.
PATRICi 21370289. VBIChlChl46571_1349.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi FQEITRE.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci CCHL340177:GHBW-1304-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Chlorobium chlorochromatii CaD3."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Bryant D., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CaD3.

Entry informationi

Entry nameiHISX_CHLCH
AccessioniPrimary (citable) accession number: Q3AR25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 22, 2005
Last modified: November 26, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3