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Q3AQN3 (PUR7_CHLCH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
EC=6.3.2.6
Alternative name(s):
SAICAR synthetase
Gene names
Name:purC
Ordered Locus Names:Cag_1435
OrganismChlorobium chlorochromatii (strain CaD3) [Complete proteome] [HAMAP]
Taxonomic identifier340177 [NCBI]
Taxonomic lineageBacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobium/Pelodictyon group › Chlorobium

Protein attributes

Sequence length235 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137

Sequence similarities

Belongs to the SAICAR synthetase family.

Ontologies

Keywords
   Biological processPurine biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine nucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoribosylaminoimidazolesuccinocarboxamide synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 235235Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137
PRO_1000018685

Sequences

Sequence LengthMass (Da)Tools
Q3AQN3 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: D154F0556811A183

FASTA23526,784
        10         20         30         40         50         60 
MNKKEQLYEG KAKKVFATDN PDLVIQEFKD DATAFNNKKK GTIADKGVVN NAISCKLFTL 

        70         80         90        100        110        120 
LEQHGIRTHL VEKLSEREML CRHLDIIKAE VVVRNIAAGS LVRRYGFAEG TVLECPIVEL 

       130        140        150        160        170        180 
YLKDDDLDDP LMIEAHAVAL GVGTFEELAH LKQQAEVINT VLRSFFAERK LKLVDFKLEF 

       190        200        210        220        230 
GRHNGEILLG DEISPDTCRF WDLATNEKLD KDRFRFDLGS VEEAYSEVER RVLEL

« Hide

References

[1]"Complete sequence of Chlorobium chlorochromatii CaD3."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Bryant D., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CaD3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000108 Genomic DNA. Translation: ABB28692.1.
RefSeqYP_379735.1. NC_007514.1.

3D structure databases

HSSPHSSP built from PDB template 1KUT based on UniProtKB Q9X0X0.
ProteinModelPortalQ3AQN3.
SMRQ3AQN3. Positions 2-233.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3AQN3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3746327.
GenomeReviewsGene locus Cag_1435 in contig CP000108_GR.
KEGGcch:Cag_1435.
PATRIC21370575. VBIChlChl46571_1490.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0152.
HOGENOMHBG306070.
OMAYKDDALG.
PhylomeDBQ3AQN3.
ProtClustDBPRK09362.

Enzyme and pathway databases

BioCycCCHL340177:CAG_1435-MONOMER.

Family and domain databases

HAMAPMF_00137. SAICAR_synth.
[Tree]
InterProIPR013816. ATP_grasp_subdomain_2.
IPR001636. SAICAR_synth.
IPR018236. SAICAR_synthetase_CS.
[Graphical view]
Gene3DG3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
KOK01923.
PANTHERPTHR11609. SAICAR_synt. 1 hit.
PfamPF01259. SAICAR_synt. 1 hit.
[Graphical view]
TIGRFAMsTIGR00081. PurC. 1 hit.
PROSITEPS01057. SAICAR_SYNTHETASE_1. False negative.
PS01058. SAICAR_SYNTHETASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePUR7_CHLCH
AccessionPrimary (citable) accession number: Q3AQN3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 22, 2005
Last modified: January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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