Q3AQ17 (GCST_CHLCH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	Cag_1656

Organism

Chlorobium chlorochromatii (strain CaD3) [Complete proteome] [HAMAP]

Taxonomic identifier

340177 [NCBI]

Taxonomic lineage

Bacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobium/Pelodictyon group › Chlorobium

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 366	366	Aminomethyltransferase HAMAP MF_00259		PRO_1000047654

Sequences

	Sequence		Length	Mass (Da)
	Q3AQ17 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 5E387192ED20C79B	FASTA	366	39,885
	10 20 30 40 50 60 MKKTALYPCH EQSGAKIIDF GGYLMPVQYA GIIAEHKAVR SAAGLFDVSH MGNFFVKGSR 70 80 90 100 110 120 ALEFLQFVTT NDLAKVVDGQ AQYNLMLYPS GGIVDDLIIY RMSADTFFLI VNASNADKDF 130 140 150 160 170 180 AWLQQHIDQF EGVTLEDHTE RLSLIALQGP LALSILNRLF PSIDGEALGS FHFCSASFNG 190 200 210 220 230 240 FDVIIARTGY TGEKGVEMCV PNEAAIALWE ALMAAGAADG IQPIGLGARD TLRLEMGYSL 250 260 270 280 290 300 YGHEINQDTN PLEARLKWVV KMDKGHFIGK EACEQAMQHP QRTVIGFSLE GRALPRQGFT 310 320 330 340 350 360 LYNSDRQAIG VVCSGTLSPT LQEPVGTCSV LREYGKPGTP ILVEVRGAFH AGIIRSLPFV TNTSLA

References

[1]

"Complete sequence of Chlorobium chlorochromatii CaD3." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Bryant D., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CaD3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000108 Genomic DNA. Translation: ABB28908.1.
RefSeq	YP_379951.1. NC_007514.1.
3D structure databases
HSSP	HSSP built from PDB template 1VLO based on UniProtKB P27248.
ProteinModelPortal	Q3AQ17.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3AQ17.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3747674.
GenomeReviews	Gene locus Cag_1656 in contig CP000108_GR.
KEGG	cch:Cag_1656.
PATRIC	21371049. VBIChlChl46571_1720.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0404.
HOGENOM	HBG299834.
OMA	KALYGGM.
PhylomeDB	Q3AQ17.
ProtClustDB	PRK00389.
Enzyme and pathway databases
BioCyc	CCHL340177:CAG_1656-MONOMER.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_CHLCH

Accession

Primary (citable) accession number: Q3AQ17

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 22, 2005
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program