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Q3AQ15

- GCSPB_CHLCH

UniProt

Q3AQ15 - GCSPB_CHLCH

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Chlorobium chlorochromatii (strain CaD3)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciCCHL340177:GHBW-1673-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 2UniRule annotation
    Glycine decarboxylase subunit 2UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
    Gene namesi
    Name:gcvPBUniRule annotation
    Ordered Locus Names:Cag_1658
    OrganismiChlorobium chlorochromatii (strain CaD3)
    Taxonomic identifieri340177 [NCBI]
    Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
    ProteomesiUP000002708: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 481481Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_1000045689Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei269 – 2691N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi340177.Cag_1658.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3AQ15.
    SMRiQ3AQ15. Positions 3-477.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239368.
    KOiK00283.
    OMAiKPVMHEF.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00713. GcvPB.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3AQ15-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKEPLIFDLS RPGRKGYSLS PCDVPEVPLE SIIPASLLRK EAVELPEVAE    50
    NEVVRHFVRL SNLNYHVDKN MYPLGSCTMK YNPKVNDYTC DLSGFSALHP 100
    LQPTSTTQGA LQLMYELSNM LAEIAGMAGV SLQPAAGAHG ELTGILLIKK 150
    YHEVRGDKRH KLLVVDSAHG TNPASAALAG YETISVKSNG DGRTDLEDLR 200
    SKLDGDVAAL MLTNPNTIGL FEKEIVQIAE MVHANGSLLY MDGANMNALL 250
    GITRPGDMGF DVMHYNLHKT FAAPHGGGGP GSGPVGVNEK LLPYLPAPLV 300
    VKEGDTYRLT SGGDDSIGRM MNFYGNFAVL VRAYTYIRML GAEGLRRVSE 350
    NAIINANYLL SKLLERYELP YPKPVMHEFC LSGDKQKKAH GVKTLDIAKR 400
    LLDYGFHAPT IYFPLIVSEA LMIEPTETES KETLDIFADA LLAIAREAEE 450
    NPDVVKMAPS TTAVKRLDEA TASRQLTICC M 481
    Length:481
    Mass (Da):52,539
    Last modified:November 22, 2005 - v1
    Checksum:iB834B974AA939889
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000108 Genomic DNA. Translation: ABB28910.1.
    RefSeqiYP_379953.1. NC_007514.1.

    Genome annotation databases

    EnsemblBacteriaiABB28910; ABB28910; Cag_1658.
    GeneIDi3747676.
    KEGGicch:Cag_1658.
    PATRICi21371053. VBIChlChl46571_1722.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000108 Genomic DNA. Translation: ABB28910.1 .
    RefSeqi YP_379953.1. NC_007514.1.

    3D structure databases

    ProteinModelPortali Q3AQ15.
    SMRi Q3AQ15. Positions 3-477.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 340177.Cag_1658.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB28910 ; ABB28910 ; Cag_1658 .
    GeneIDi 3747676.
    KEGGi cch:Cag_1658.
    PATRICi 21371053. VBIChlChl46571_1722.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239368.
    KOi K00283.
    OMAi KPVMHEF.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci CCHL340177:GHBW-1673-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00713. GcvPB.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Chlorobium chlorochromatii CaD3."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Bryant D., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CaD3.

    Entry informationi

    Entry nameiGCSPB_CHLCH
    AccessioniPrimary (citable) accession number: Q3AQ15
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3