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Q3AQ15

- GCSPB_CHLCH

UniProt

Q3AQ15 - GCSPB_CHLCH

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 2
Gene
gcvPB, Cag_1658
Organism
Chlorobium chlorochromatii (strain CaD3)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCCHL340177:GHBW-1673-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene namesi
Name:gcvPB
Ordered Locus Names:Cag_1658
OrganismiChlorobium chlorochromatii (strain CaD3)
Taxonomic identifieri340177 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
ProteomesiUP000002708: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 481481Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation
PRO_1000045689Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei269 – 2691N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi340177.Cag_1658.

Structurei

3D structure databases

ProteinModelPortaliQ3AQ15.
SMRiQ3AQ15. Positions 3-477.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiKPVMHEF.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3AQ15-1 [UniParc]FASTAAdd to Basket

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MKEPLIFDLS RPGRKGYSLS PCDVPEVPLE SIIPASLLRK EAVELPEVAE    50
NEVVRHFVRL SNLNYHVDKN MYPLGSCTMK YNPKVNDYTC DLSGFSALHP 100
LQPTSTTQGA LQLMYELSNM LAEIAGMAGV SLQPAAGAHG ELTGILLIKK 150
YHEVRGDKRH KLLVVDSAHG TNPASAALAG YETISVKSNG DGRTDLEDLR 200
SKLDGDVAAL MLTNPNTIGL FEKEIVQIAE MVHANGSLLY MDGANMNALL 250
GITRPGDMGF DVMHYNLHKT FAAPHGGGGP GSGPVGVNEK LLPYLPAPLV 300
VKEGDTYRLT SGGDDSIGRM MNFYGNFAVL VRAYTYIRML GAEGLRRVSE 350
NAIINANYLL SKLLERYELP YPKPVMHEFC LSGDKQKKAH GVKTLDIAKR 400
LLDYGFHAPT IYFPLIVSEA LMIEPTETES KETLDIFADA LLAIAREAEE 450
NPDVVKMAPS TTAVKRLDEA TASRQLTICC M 481
Length:481
Mass (Da):52,539
Last modified:November 22, 2005 - v1
Checksum:iB834B974AA939889
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000108 Genomic DNA. Translation: ABB28910.1.
RefSeqiYP_379953.1. NC_007514.1.

Genome annotation databases

EnsemblBacteriaiABB28910; ABB28910; Cag_1658.
GeneIDi3747676.
KEGGicch:Cag_1658.
PATRICi21371053. VBIChlChl46571_1722.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000108 Genomic DNA. Translation: ABB28910.1 .
RefSeqi YP_379953.1. NC_007514.1.

3D structure databases

ProteinModelPortali Q3AQ15.
SMRi Q3AQ15. Positions 3-477.
ModBasei Search...

Protein-protein interaction databases

STRINGi 340177.Cag_1658.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB28910 ; ABB28910 ; Cag_1658 .
GeneIDi 3747676.
KEGGi cch:Cag_1658.
PATRICi 21371053. VBIChlChl46571_1722.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi KPVMHEF.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci CCHL340177:GHBW-1673-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Chlorobium chlorochromatii CaD3."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Bryant D., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CaD3.

Entry informationi

Entry nameiGCSPB_CHLCH
AccessioniPrimary (citable) accession number: Q3AQ15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 22, 2005
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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