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Q3APY8

- Q3APY8_CHLCH

UniProt

Q3APY8 - Q3APY8_CHLCH

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Protein
Acetyl-coenzyme A synthetase
Gene
acsA, Cag_1685
Organism
Chlorobium chlorochromatii (strain CaD3)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA By similarity.UniRule annotation

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei331 – 3311Coenzyme A By similarityUniRule annotation
Binding sitei355 – 3551Coenzyme A By similarityUniRule annotation
Binding sitei407 – 4071Substrate; via nitrogen amide By similarityUniRule annotation
Binding sitei520 – 5201Substrate By similarityUniRule annotation
Binding sitei535 – 5351Substrate By similarityUniRule annotation
Active sitei537 – 5371 By similarityUniRule annotation
Binding sitei543 – 5431Coenzyme A By similarityUniRule annotation
Binding sitei546 – 5461Substrate By similarityUniRule annotation
Metal bindingi557 – 5571Magnesium; via carbonyl oxygen By similarityUniRule annotation
Metal bindingi559 – 5591Magnesium; via carbonyl oxygen By similarityUniRule annotation
Metal bindingi562 – 5621Magnesium; via carbonyl oxygen By similarityUniRule annotation
Binding sitei604 – 6041Coenzyme A By similarityUniRule annotation

GO - Molecular functioni

  1. AMP binding Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. acetate-CoA ligase activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. acetyl-CoA biosynthetic process from acetate Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciCCHL340177:GHBW-1701-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A synthetaseUniRule annotation (EC:6.2.1.1UniRule annotation)
Short name:
AcCoA synthetaseUniRule annotation
Short name:
AcsUniRule annotation
Alternative name(s):
Acetate--CoA ligase
Acyl-activating enzyme
Gene namesi
Name:acsAUniRule annotation
Ordered Locus Names:Cag_1685Imported
OrganismiChlorobium chlorochromatii (strain CaD3)Imported
Taxonomic identifieri340177 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
ProteomesiUP000002708: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei629 – 6291N6-acetyllysine By similarityUniRule annotation

Post-translational modificationi

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity.UniRule annotation

Keywords - PTMi

AcetylationUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi340177.Cag_1685.

Structurei

3D structure databases

ProteinModelPortaliQ3APY8.
SMRiQ3APY8. Positions 31-664.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni431 – 4366Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0365.
HOGENOMiHOG000229981.
KOiK01895.
OMAiYNNDERF.
OrthoDBiEOG68WR2H.

Family and domain databases

HAMAPiMF_01123. Ac_CoA_synth.
InterProiIPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3APY8-1 [UniParc]FASTAAdd to Basket

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MATETPSSSQ QEAAANPAED SISSVLTEKR KFPPPASFSE QAHLSTMEQY    50
EKLYADAAAD PEGYWAGIAE QFHWFKKWDS VLEWNSPYAK WFNGGKTNIC 100
YNALDVHVKS WRKNKAAVIW EGEQGDQRIL TYGELHRQVC KFANVLKIAG 150
IKPGDRIAIY MGMVPELMIA VLACARVGAV HNVIFAGFSA HAITERVNDS 200
RAKMVICADG TRRRGSTINL KNIVDEAIVN TPSVRNVIVL KTTGETIKMH 250
DGMDHWWHDL MGLAVDESEA VELDAEHPLF VLYTSGSTGK PKGILHTTAG 300
YMVHAASSFR YVFDIKDEDI YFCTADIGWI TGHSYMVYGP LLNGATLLMY 350
EGAPNYPQWD RFWDIINRHK VTILYTAPTA IRAFIRAGNE WVTKHNLNSL 400
RLLGTVGEPI NPEAWMWYHK VVGQEKCPIV DTWWQTETGG IMVSPMPGAT 450
PTKPGTATRP LPGIMVDVVH KDGTPCGANE GGYLVIKKPW PSMLRTIYGD 500
NERYEKTYWS EFKDMYFTGD GARKDDDGYI WIMGRVDDVV NVSGHRLGTS 550
EVESALVSHE AVAEAAVVSR PDDIKGNSLV AFVTLKDEYE GDMKLRESLR 600
NHVAREIGPI AKPDEIRWAK ALPKTRSGKI MRRLLRELAT SNEIKGDVTT 650
LEDFGVLENL RDQENE 666
Length:666
Mass (Da):74,565
Last modified:November 22, 2005 - v1
Checksum:iBAC348AF52226EDF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000108 Genomic DNA. Translation: ABB28937.1.
RefSeqiWP_011362699.1. NC_007514.1.
YP_379980.1. NC_007514.1.

Genome annotation databases

EnsemblBacteriaiABB28937; ABB28937; Cag_1685.
GeneIDi3746375.
KEGGicch:Cag_1685.
PATRICi21371113. VBIChlChl46571_1751.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000108 Genomic DNA. Translation: ABB28937.1 .
RefSeqi WP_011362699.1. NC_007514.1.
YP_379980.1. NC_007514.1.

3D structure databases

ProteinModelPortali Q3APY8.
SMRi Q3APY8. Positions 31-664.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 340177.Cag_1685.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB28937 ; ABB28937 ; Cag_1685 .
GeneIDi 3746375.
KEGGi cch:Cag_1685.
PATRICi 21371113. VBIChlChl46571_1751.

Phylogenomic databases

eggNOGi COG0365.
HOGENOMi HOG000229981.
KOi K01895.
OMAi YNNDERF.
OrthoDBi EOG68WR2H.

Enzyme and pathway databases

BioCyci CCHL340177:GHBW-1701-MONOMER.

Family and domain databases

HAMAPi MF_01123. Ac_CoA_synth.
InterProi IPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Chlorobium chlorochromatii CaD3."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Bryant D., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CaD3Imported.

Entry informationi

Entry nameiQ3APY8_CHLCH
AccessioniPrimary (citable) accession number: Q3APY8
Entry historyi
Integrated into UniProtKB/TrEMBL: November 22, 2005
Last sequence update: November 22, 2005
Last modified: September 3, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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